Abstract: Objective To investigate the clinical application of hyperoxic Ringers solution in the treatment of the burn patients with inhalation injury at the early postburn stage. Methods Eight patients with over 30% TBSA and moderate inhalation injury were randomly enrolled in the study ( + ), while other 4 cases with similar conditions as control( - ). Intravenous infusion of 1500ml hyperoxic Ringers solution were given to the patients every day and for 7 days in the former group, while equal amount of Ringer's solution was given to the patients in the control group. The vital signs, the blood biochemical indices and the blood gas analysis of the two groups were monitored dynamically. Results The vital signs of the patients in group T were steady with slight changes in the blood biochemical indices when compared with those in group C, while the level in PaO₂ was significantly higher than that in group C( P <0.05). Conclusion The infusion of hyperoxic Ringer's solution is beneficial in the early treatment of burn patients with inhalation injury.