Abstract: Burn surgery in the 21st century is now facing both serious challenges and opportunities for development. Interlacing of different disciplines is not only the source of scientific innovation and development in science of burn surgery, but also the trend of advancement of the discipline in the future. Therefore, it is imperative that burn surgery should strengthen multidisciplinary cooperation in order to develop new treatment concept and technology, widen and deepen basic researches with interdisciplinary methodology, and combine the translational medicine, integration medicine, and precision medicine, in order to form the salient feature of discipline of burn surgery.