Abstract: Mononuclear cell -derived multipotential cell (MOMC)is a unique cell population that derived from circulating CD14 ⁺ mononuclear cell, with phenotypic characteristics of CD14⁺ , CD45⁺ , CD34⁺ , as well as type Ⅰ collagen. It can be induced to differentiate into a wide range of mesenchymal lineages, including endothelium-like cells, myocardium-like cells, neuron-like cells, osteoid cells, chondroid cells, lipoid cells, myoid cells, epidermoid cells, and hepatoid cells. More strikingly, MOMC is easy to be obtained, and it can expand easily in vitro, which can be transplantated autologously without ethical limitations. MOMC is an ideal source of cell therapy for tissue regeneration and wound repair.