Abstract: In order to ameliorate the prognosis of patients in burn disaster, national emergency medical rescue expert teams are usually dispatched to incident areas. This article discusses the major work and challenges of the medical rescue expert teams using example of rescuing gas explosion accident in Hangzhou in last few days and author′s personal experience of previous mission. The foremost mission of medical rescue expert teams is to provide feasible strategic advice for burn disaster rescue and pivotal critical care support. The medical rescue expert teams always begin their work in hospitals lack of experience in disaster rescue. According to the characteristics of"7·21"Hangzhou gas explosion accident, the medical rescue expert teams focus on reassessment of the severity and hidden injuries of all patients, referral of patients according to the homeostasis status in patients with different severity, developing medical safety strategies, medical-related public safety strategies, and nosocomial infection control measure for rescue work. Furthermore, the medical rescue expert teams join the treatment for some critically ill patients and sudden emergency cases. The main challenges of medical rescue experts faced are accumulation and improvement of personal medical skill and powerful psychological endurance. Psychological counseling can play beneficial role in rescue group. In addition, establishing coordinated relationship among national emergency medical rescue expert teams, local administration, and local medical group shall be beneficial to disaster rescue.