Role of nuclear factor-κB activation in sepsis-induced myocardial dysfunction
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Abstract: As a common complication in patients with sepsis, cardiac dysfunction may significantly increase mortality of these patients, but its mechanism is still unclear. Nuclear factor-κB (NF-κB) is a pleiotropic transcription inducing factor, which involves in the regulation of multiple biological phenomena and disease status. NF-κB activation participates in cardiomyocyte apoptosis, cardiomyocyte autophagy, and release of inflammatory cytokines in patients with sepsis, indicating its important role in sepsis-induced myocardial dysfunction.
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Key words:
- NF-kappa B /
- Sepsis /
- Cardiomyopathies /
- Apoptosis /
- Autophagy /
- Inflammatory cytokine
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