Abstract: Analgesia and sedation play important roles in the overall treatment of critically burned adult patients. According to clinical actual situation of critically burned adult patients, a set of analgesic and sedative practices, including analgesia-based sedation, scientifically reasonable sedation status monitoring, early goal-directed sedation strategy, standardized and individualized strategy for analgesia and sedation, and early comfort using analgesia, minimal sedative, maximal human care strategy are recommended and widely implemented nowadays. However, guideline or consensus about how to provide analgesia and sedation treatment for critically burned adult patients is lacking. In this article, we discuss strategy for analgesic and sedative management in critically burned adult patients, with preexisting ideas in critical care medicine, pathophysiological characteristics of critically burned patients, and our clinical practice for reference.