Advances in the research of delivery system of growth factor and the gene for promoting wound healing
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摘要: 生长因子在创面愈合过程中发挥着重要作用。局部应用生长因子治疗是一种较佳的促进创面愈合的方法,但由于生长因子在创面局部易被水解,其疗效具有剂量和时间依赖性,因此需要合适的生长因子递呈系统协助其发挥作用。除向创面直接递呈生长因子外,还可利用病毒和非病毒载体向创面转染生长因子基因,并进一步转录、翻译为生长因子,从而促进创面愈合。本文主要对促进创面愈合的生长因子及基因递呈系统的研究进展做一综述。Abstract: Growth factors play critical roles in the process of wound healing. Application of growth factor locally is a good way of promoting wound healing, while it is easy to be hydrolyzed in wounds and its efficacy has dose- and time-dependent manner. Therefore, appropriate growth factor delivery system is needed to assist it to function in wounds. In addition to delivering growth factor directly to wounds, viral and non-viral vectors can be used for gene transfection of growth factor in wounds. The gene can be transformed to growth factor to promote wound healing by transcription and translation. This article reviews the advances in the research of delivery system of growth factor and the gene for promoting wound healing.
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Key words:
- Drug carriers /
- Genes /
- Wound healing /
- Growth factor
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