Email Alerts
RSS
Volume 37 Issue 10
Oct.  2021
Turn off MathJax
Article Contents
Article Navigation >  CHINESE JOURNAL OF BURNS AND WOUNDS  > 2021  >  37(10): 1000-1004
Guo XY,Xie WG.Research progress on the mechanism of wound skin dyspigmentation after burns[J].Chin J Burns,2021,37(10):1000-1004.DOI: 10.3760/cma.j.cn501120-20200714-00344.
Citation: Guo XY,Xie WG.Research progress on the mechanism of wound skin dyspigmentation after burns[J].Chin J Burns,2021,37(10):1000-1004.DOI: 10.3760/cma.j.cn501120-20200714-00344.
shu

Research progress on the mechanism of wound skin dys- pigmentation after burns

doi: 10.3760/cma.j.cn501120-20200714-00344

  • Institute of Burns, Tongren Hospital of Wuhan University & Wuhan Third Hospital, Wuhan 430060, China

Funds:

Action Plan for Science and Technology in Major Disease Prevention and Control 2018-ZX-01S-001

Medical Research Project of Wuhan WG18Q10

More Information
  • Corresponding author: Xie Weiguo, Email: wgxie@hotmail.com
  • Received Date: 2020-07-14
    Abstract
  • Burn wound healing often shows a certain degree of pigmentation disorder. It may not only cause cosmetic and psychological issues affecting patient's normal social activities, but also increase risk of skin cancer or photoaging. Although normal skin pigmentation is fairly well studied, the mechanism that leads to dyspigmentation after burn injury needs to be further explored. Based on summarizing the mechanism of normal skin pigmentation, this paper reviews the latest research progress in postburn dyspigmentation in recent years.

     

    • FullText(HTML)
  • loading
    • References(43)
  • [1]
    LinJY,FisherDE.Melanocyte biology and skin pigmentation[J].Nature,2007,445(7130):843-850.DOI: 10.1038/nature05660.
    [2]
    SpronkI,PolinderS,HaagsmaJA,et al.Patient-reported scar quality of adults after burn injuries: a five-year multicenter follow-up study[J].Wound Repair Regen,2019,27(4):406-414.DOI: 10.1111/wrr.12709.
    [3]
    DaiNT,ChangHI,WangYW,et al.Restoration of skin pigmentation after deep partial or full-thickness burn injury[J].Adv Drug Deliv Rev,2018,123:155-164.DOI: 10.1016/j.addr.2017.10.010.
    [4]
    ShainAH,BastianBC.From melanocytes to melanomas[J].Nat Rev Cancer,2016,16(6):345-358.DOI: 10.1038/nrc.2016.37.
    [5]
    AbbasK,QadirMI,AnwarS.The role of melanin in skin cancer[J].Crit Rev Eukaryot Gene Expr,2019,29(1):17-24.DOI: 10.1615/CritRevEukaryotGeneExpr.2018024980.
    [6]
    Del BinoS,DuvalC,BernerdF.Clinical and biological characterization of skin pigmentation diversity and its consequences on UV impact[J].Int J Mol Sci,2018,19(9):2668.DOI: 10.3390/ijms19092668.
    [7]
    d'IschiaM,WakamatsuK,et al.Melanins and melanogenesis: from pigment cells to human health and technological applications[J].Pigment Cell Melanoma Res,2015,28(5):520-544.DOI: 10.1111/pcmr.12393.
    [8]
    ItoS,WakamatsuK.Chemistry of mixed melanogenesis—pivotal roles of dopaquinone[J].Photochem Photobiol,2008,84(3):582-592.DOI: 10.1111/j.1751-1097.2007.00238.x.
    [9]
    D'MelloSA,FinlayGJ,et al.Signaling pathways in melanogenesis[J].Int J Mol Sci,2016, 17(7):1144.DOI: 10.3390/ijms17071144.
    [10]
    PavanWJ,SturmRA.The genetics of human skin and hair pigmentation[J].Annu Rev Genomics Hum Genet,2019,20:41-72.DOI: 10.1146/annurev-genom-083118-015230.
    [11]
    SchallreuterKU,KothariS,ChavanB,et al.Regulation of melanogenesis—controversies and new concepts[J].Exp Dermatol,2008,17(5):395-404.DOI: 10.1111/j.1600-0625.2007.00675.x.
    [12]
    HidaT,WakamatsuK,SviderskayaEV,et al.Agouti protein, mahogunin, and attractin in pheomelanogenesis and melanoblast-like alteration of melanocytes: a cAMP-independent pathway[J].Pigment Cell Melanoma Res,2009,22(5):623-634.DOI: 10.1111/j.1755-148X.2009.00582.x.
    [13]
    Wolf HorrellEM,BoulangerMC, D'OrazioJA.Melanocortin 1 receptor: structure, function, and regulation[J].Front Genet,2016,7:95.DOI: 10.3389/fgene.2016.00095.
    [14]
    SebergHE,Van OtterlooE,CornellRA.Beyond MITF: multiple transcription factors directly regulate the cellular phenotype in melanocytes and melanoma[J].Pigment Cell Melanoma Res,2017,30(5):454-466.DOI: 10.1111/pcmr.12611.
    [15]
    KordaßT,WeberCE,OswaldM,et al.SOX5 is involved in balanced MITF regulation in human melanoma cells[J].BMC Med Genomics,2016,9:10.DOI:1 0.1186/s12920-016-0170-0.
    [16]
    GuoH,XingY,LiuY,et al.Wnt/β-catenin signaling pathway activates melanocyte stem cells in vitro and in vivo[J].J Dermatol Sci,2016,83(1):45-51.DOI: 10.1016/j.jdermsci.2016.04.005.
    [17]
    LeeAY.Recent progress in melasma pathogenesis[J].Pigment Cell Melanoma Res,2015,28(6):648-660.DOI: 10.1111/pcmr.12404.
    [18]
    KumariS,Tien Guan ThngS,Kumar VermaN,et al.Melanogenesis inhibitors[J].Acta Derm Venereol,2018,98(10):924-931.DOI: 10.2340/00015555-3002.
    [19]
    YuanXH,JinZH.Paracrine regulation of melanogenesis[J].Br J Dermatol,2018,178(3):632-639.DOI: 10.1111/bjd.15651.
    [20]
    KinslechnerK,SchützB,PistekM,et al.Loss of SR-BI down- regulates MITF and suppresses extracellular vesicle release in human melanoma[J].Int J Mol Sci,2019,20(5):1063.DOI: 10.3390/ijms20051063.
    [21]
    DunnKJ,BradyM,Ochsenbauer-JamborC,et al.WNT1 and WNT3a promote expansion of melanocytes through distinct modes of action[J].Pigment Cell Res,2005,18(3):167-180.DOI: 10.1111/j.1600-0749.2005.00226.x.
    [22]
    NguyenNT,FisherDE.MITF and UV responses in skin: from pigmentation to addiction[J].Pigment Cell Melanoma Res,2019,32(2):224-236.DOI: 10.1111/pcmr.12726.
    [23]
    SchallreuterKU,KothariS,HasseS,et al.In situ and in vitro evidence for DCoH/HNF-1 alpha transcription of tyrosinase in human skin melanocytes[J].Biochem Biophys Res Commun,2003,301(2):610-616.DOI: 10.1016/s0006-291x(02)03076-0.
    [24]
    LiPH,LiuLH,ChangCC,et al.Silencing stem cell factor gene in fibroblasts to regulate paracrine factor productions and enhance c-Kit expression in melanocytes on melanogenesis[J].Int J Mol Sci,2018,19(5):1475.DOI: 10.3390/ijms19051475.
    [25]
    GarmynM,YoungAR,MillerSA.Mechanisms of and variables affecting UVR photoadaptation in human skin[J].Photochem Photobiol Sci,2018,17(12):1932-1940.DOI: 10.1039/c7pp00430c.
    [26]
    CichorekM,WachulskaM,StasiewiczA,et al.Skin melanocytes: biology and development[J].Postepy Dermatol Alergol,2013,30(1):30-41.DOI: 10.5114/pdia.2013.33376.
    [27]
    TravisTE,GhassemiP,Ramella-RomanJC,et al.A multimodal assessment of melanin and melanocyte activity in abnormally pigmented hypertrophic scar[J].J Burn Care Res,2015,36(1):77-86.DOI: 10.1097/BCR.0000000000000154.
    [28]
    ChouWC,TakeoM,RabbaniP,et al.Direct migration of follicular melanocyte stem cells to the epidermis after wounding or UVB irradiation is dependent on Mc1r signaling[J].Nat Med,2013,19(7):924-929.DOI: 10.1038/nm.3194.
    [29]
    樊蕊蕊,刘菲琳,郝德顺,等.毛囊源性黑色素细胞的生物学特性及其体外培养技术研究进展[J/CD].中华细胞与干细胞杂志:电子版,2017,7(2):117-123.DOI: 10.3877/cma.j.issn.2095-1221.2017.02.010.
    [30]
    SharpeJR,BoothS,JubinK,et al.Progression of wound pH during the course of healing in burns[J].J Burn Care Res,2013,34(3):e201-e208.DOI: 10.1097/BCR.0b013e31825d5569.
    [31]
    SaekiH,OikawaA.Stimulation by ionophores of tyrosinase activity of mouse melanoma cells in culture[J].J Invest Dermatol,1985,85(5):423-425.DOI: 10.1111/1523-1747.ep12277091.
    [32]
    JothishankarB,SteinSL.Impact of skin color and ethnicity[J].Clin Dermatol,2019,37(5):418-429.DOI: 10.1016/j.clindermatol.2019.07.009.
    [33]
    RogasevskaiaTP,SzerencseiRT,JalloulAH,et al.Cellular localization of the K+-dependent Na+-Ca2+ exchanger NCKX5 and the role of the cytoplasmic loop in its distribution in pigmented cells[J].Pigment Cell Melanoma Res,2019,32(1):55-67.DOI: 10.1111/pcmr.12723.
    [34]
    AmbrosioAL,BoyleJA,AradiAE,et al.TPC2 controls pigmentation by regulating melanosome pH and size[J].Proc Natl Acad Sci U S A,2016,113(20):5622-5627.DOI: 10.1073/pnas.1600108113.
    [35]
    JeschkeMG,van BaarME,ChoudhryMA,et al.Burn injury[J].Nat Rev Dis Primers,2020,6(1):11.DOI: 10.1038/s41572-020-0145-5.
    [36]
    HurJ,YangHT,ChunW,et al.Inflammatory cytokines and their prognostic ability in cases of major burn injury[J].Ann Lab Med,2015,35(1):105-110.DOI: 10.3343/alm.2015.35.1.105.
    [37]
    SchwachaMG,ThobeBM,DanielT,et al.Impact of thermal injury on wound infiltration and the dermal inflammatory response[J].J Surg Res,2010,158(1):112-120.DOI: 10.1016/j.jss.2008.07.034.
    [38]
    SchwachaMG,NickelE,DanielT.Burn injury-induced alterations in wound inflammation and healing are associated with suppressed hypoxia inducible factor-1alpha expression[J].Mol Med,2008,14(9/10):628-633.DOI: 10.2119/2008-00069.Schwacha.
    [39]
    CostinGE,HearingVJ.Human skin pigmentation: melanocytes modulate skin color in response to stress[J].FASEB J,2007,21(4):976-994.DOI: 10.1096/fj.06-6649rev.
    [40]
    PillaiyarT,ManickamM,JungSH.Recent development of signaling pathways inhibitors of melanogenesis[J].Cell Signal,2017,40:99-115.DOI: 10.1016/j.cellsig.2017.09.004.
    [41]
    AdiniI,AdiniA,BazinetL,et al.Melanocyte pigmentation inversely correlates with MCP-1 production and angiogenesis-inducing potential[J].FASEB J,2015,29(2):662-670.DOI: 10.1096/fj.14-255398.
    [42]
    CarneyBC,ChenJH,LukerJN,et al.Pigmentation diathesis of hypertrophic scar: an examination of known signaling pathways to elucidate the molecular pathophysiology of injury-related dyschromia[J].J Burn Care Res,2019,40(1):58-71.DOI: 10.1093/jbcr/iry045.
    [43]
    AlkhalilA,CarneyBC,TravisTE,et al.Dyspigmented hypertrophic scars:beyond skin color[J].Pigment Cell Melanoma Res,2019,32(5):643-656.DOI: 10.1111/pcmr.12780.
    • Relative Articles
    • Supplements(0)
    • Cited By
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Tables(1)

    Get Citation
    PDF
    XML

    Article Metrics

    Article views (319) PDF downloads(51) Cited by()
    Proportional views
    Related

    Copyright © Chinese Journal of Burns京ICP备07035254号-14

    E-mail：shaoshangzazhi@163.com

    Website：https://zhsszz.xml-journal.net/

    Supported by: Beijing Renhe Information Technology Co. Ltd    

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return