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Volume 38 Issue 1
Jan.  2022
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Article Navigation >  CHINESE JOURNAL OF BURNS AND WOUNDS  > 2022  >  38(1): 84-89
Liao YY,Zhang PH.Research advances on the role of competing endogenous RNAs in wound healing[J].Chin J Burns Wounds,2022,38(1):84-89.DOI: 10.3760/cma.j.cn501120-20201125-00498.
Citation: Liao YY,Zhang PH.Research advances on the role of competing endogenous RNAs in wound healing[J].Chin J Burns Wounds,2022,38(1):84-89.DOI: 10.3760/cma.j.cn501120-20201125-00498.
shu

Research advances on the role of competing endogenous RNAs in wound healing

doi: 10.3760/cma.j.cn501120-20201125-00498

  • Department of Burns and Plastic Surgery, Xiangya Hospital, Central South University, Changsha 410008, China

Funds:

General Program of National Natural Science Foundation of China 81772084

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  • Corresponding author: Zhang Pihong, Email: zphong@aliyun.com
  • Received Date: 2020-11-25
    Abstract
  • Wound healing, as one of the important public health issues, has been a worldwide problem. Due to the unique biological wound environment, wound healing is a very complex process with current treatments requiring long cycles, being poorly effective, and bringing high economic burden to patients. An increasing number of studies have shown that non-coding RNAs (ncRNAs) play important roles in wound healing process. The competing endogenous RNAs (ceRNAs) hypothesis in recent years is a new proposal on the inter-regulation of RNAs, which suggests a "mode of communication" between different RNAs. ceRNA regulatory network (ceRNET) combines the functions of protein-coding mRNA with ncRNA (e.g., microRNA, long non-coding RNA, pseudogenes, and circular RNA). Recent studies have shown that ceRNAs play important roles in wound healing, which may provide new effective therapeutic targets for wound healing. This paper starting with ceRNET systematically reviewed the research progress on the effects of various ceRNAs in wound healing and the future research challenges, with the aim to deeply explore the molecular mechanisms and clinical significance of ceRNAs in the process of wound healing.

     

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