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Volume 38 Issue 4
Apr.  2022
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Article Navigation >  CHINESE JOURNAL OF BURNS AND WOUNDS  > 2022  >  38(4): 393-399
Liu WJ,Liu DW.Research advances on mesenchymal stem cell-derived extracellular vesicles in promoting angiogenesis of diabetic ulcers[J].Chin J Burns Wounds,2022,38(4):393-399.DOI: 10.3760/cma.j.cn501120-20201207-00520.
Citation: Liu WJ,Liu DW.Research advances on mesenchymal stem cell-derived extracellular vesicles in promoting angiogenesis of diabetic ulcers[J].Chin J Burns Wounds,2022,38(4):393-399.DOI: 10.3760/cma.j.cn501120-20201207-00520.
shu

Research advances on mesenchymal stem cell-derived extracellular vesicles in promoting angiogenesis of diabetic ulcers

doi: 10.3760/cma.j.cn501120-20201207-00520
  • 1.

    Department of Burns and Plastic Surgery, Jiangxi General Hospital of Armed Police, Nanchang 330030,China

  • 2.

    Department of Burns, the First Affiliated Hospital of Nanchang University, Nanchang 330006, China

Funds:

Regional Science Foundation Project of National Natural Science Foundation of China 81460293

More Information
  • Corresponding author: Liu Dewu, Email: dewuliu@126.com
  • Received Date: 2020-12-07
    Abstract
  • Extracellular vesicles are nanoparticles secreted by most eukaryotic cells and play important roles in material transport and information transmission between cells, involved in inflammation, angiogenesis, antigen presentation, cell apoptosis, cell differentiation, and other biological processes. The culture supernatant of mesenchymal stem cells is rich in extracellular vesicles, and the extracellular vesicles can regulate the formation of new blood vessels, a key step in wound healing and tissue repair. The persistence of diabetic ulcers is closely related to the blocked formation of wound vascular network. This article reviews the role of extracellular vesicles derived from mesenchymal stem cells in promoting angiogenesis of diabetic ulcers, in order to provide a new idea for the treatment of diabetic ulcers.

     

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