Volume 39 Issue 2
Feb.  2023
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You AJ,Li WJ,Zhou JL,et al.Meta-analysis of the effects of xenogeneic acellular dermal matrix dressings in the treatment of wounds in burn patients[J].Chin J Burns Wounds,2023,39(2):175-183.DOI: 10.3760/cma.j.cn501120-20220106-00008.
Citation: You AJ,Li WJ,Zhou JL,et al.Meta-analysis of the effects of xenogeneic acellular dermal matrix dressings in the treatment of wounds in burn patients[J].Chin J Burns Wounds,2023,39(2):175-183.DOI: 10.3760/cma.j.cn501120-20220106-00008.

Meta-analysis of the effects of xenogeneic acellular dermal matrix dressings in the treatment of wounds in burn patients

doi: 10.3760/cma.j.cn501120-20220106-00008
Funds:

Guangdong Provincial Education Department University Special Innovation Project 2020KTSCX025

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  • Corresponding author: Li Chun, Email: 376962485@qq.com
  • Received Date: 2022-01-06
  •   Objective  To evaluate the efficacy and safety of xenogeneic acellular dermal matrix (ADM) dressings for the treatment of wounds in burn patients.  Methods  The meta-analysis method was adopted. Databases including Chinese Journal Full-text Database, Wanfang Database, VIP Database, and Chinese Biomedical Database were retrieved with the search terms in Chinese version of "异种脱细胞真皮基质, 敷料, 烧伤创面, 烧伤" and PubMed, Embase, Web of Science, and Cochrane Library were retrieved with the search terms in English version of "xenogeneic acellular dermal matrix, dressing, burn wound, burn" to obtain the publicly published randomized controlled trials on the efficacy of xenogeneic ADM dressings for the treatment of wounds in burn patients from the establishment of each database to December 2021. The outcome indexes included wound healing time, ratio of scar hyperplasia, Vancouver scar scale (VSS) score, ratio of complications, ratio of skin grafting, and ratio of bacteria detection. Rev Man 5.3 and Stata 14.0 statistical softwares were used to conduct a meta-analysis of eligible studies.  Results  A total of 1 596 burn patients from 16 studies were included, including 835 patients in experimental group who received xenogeneic ADM dressings therapy and 761 patients in control group who received other methods therapy. The bias risk of all the 16 included studies was uncertain. Compared with those in control group, patients in experimental group had significantly shorter wound healing time, lower VSS scores (with standardized mean differences of -2.50 and -3.10, 95% confidence intervals of -3.02--1.98 and -4.87--1.34, respectively, P values both <0.05), and lower ratios of scar hyperplasia, complications, skin grafting, and bacteria detection (with relative risks of 0.58, 0.23, 0.32, and 0.27, 95% confidence intervals of 0.43-0.80, 0.14-0.37, 0.15-0.67, and 0.11-0.69, respectively, P<0.05). Subgroup analysis showed that the difference of intervention measures in control group might be the source of heterogeneity in wound healing time. There was no publication bias in ratio of scar hyperplasia (P≥0.05), while there was publication bias in wound healing time, VSS score, and ratio of complications (P<0.05).  Conclusions  Xenogeneic ADM dressings can shorten the wound healing time of burn patients, reduce the VSS score and the ratios of scar hyperplasia, complications, skin grafting, and bacteria detection.

     

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  • [1]
    LegrandM,DépretF,MalletV.Management of burns[J].N Engl J Med,2019,381(12):1188-1189.DOI: 10.1056/NEJMc1909342.
    [2]
    ChurchD, ElsayedS, ReidO, et al. Burn wound infections[J]. Clin Microbiol Rev, 2006,19(2):403-434.DOI: 10.1128/CMR.19.2.403-434.2006.
    [3]
    贾晓明. 异种(体)生物材料与创面修复[J/CD]. 中华损伤与修复杂志:电子版,2020,15(5):341-346. DOI: 10.3877/cma.j.issn.1673-9450.2020.05.003.
    [4]
    PatelS, ZiaiK, LighthallJG, et al. Biologics and acellular dermal matrices in head and neck reconstruction: a comprehensive review[J]. Am J Otolaryngol, 2022,43(1):103233.DOI: 10.1016/j.amjoto.2021.103233.
    [5]
    HigginsJPT, GreenS. Cochrane handbook for systematic reviews of interventions version 5.1.0[M/OL]. London: the Cochrane Collaboration,2011[2022-01-06].http://www.cochrane.org/handbook. http://www.cochrane.org/handbook
    [6]
    冯祥生,潘银根,谭家驹,等.异种(猪)脱细胞真皮基质一次性包扎治疗深Ⅱ度烧伤[J].中华外科杂志,2006,44(7):467-470.DOI: 10.3760/j:issn:0529-5815.2006.07.009.
    [7]
    陈善伟,邓李敏,李东. 异种脱细胞真皮基质一次性包扎治疗Ⅱ度烧伤32例的临床观察[J]. 广西医学,2010,32(9):1076-1078. DOI: 10.3969/j.issn.0253-4304.2010.09.023.
    [8]
    覃秋海,黄运严,边建民,等. 脱细胞异种(猪)真皮早期覆盖治疗Ⅱ度烧伤创面的临床研究[J]. 广西医学,2012,34(1):26-28. DOI: 10.3969/j.issn.0253-4304.2012.01.009.
    [9]
    曹峰,张毅,杨敏杰.应用异种脱细胞真皮对浅度烧伤创面进行早期覆盖封闭的效果分析[J].当代医药论丛,2014,12(20):243-244.
    [10]
    邱玉友,江敏君,黄秀芹. 异种脱细胞真皮基质敷料对烧伤创面的治疗与护理[J]. 护理实践与研究,2015,12(6):46-47. DOI: 10.3969/j.issn.1672-9676.2015.06.023.
    [11]
    胡检,黄宇斌,黄志斌,等. 异种脱细胞真皮基质敷料对深Ⅱ°烧伤创面愈合的临床研究[J]. 中国医药导刊,2015,17(2):165-166. DOI: 10.3969/j.issn.1009-0959.2015.02.025.
    [12]
    黄亚川,朱秀梅,刘晓梅,等. 异种脱细胞真皮基质敷料在小儿烧伤中的应用观察[J]. 陕西医学杂志,2016,45(9):1154-1155. DOI: 10.3969/j.issn.1000-7377.2016.09.023.
    [13]
    李津. 早期应用脱细胞(猪)真皮基质敷料促进小儿面部Ⅱ度烧伤创面康复的临床研究[J]. 中国伤残医学,2016,24(14):71-72. DOI: 10.13214/j.cnki.cjotadm.2016.14.052.
    [14]
    吴日强,邓永高,陈伟明,等. 细胞(猪)真皮基质早期封闭小儿浅度烧伤创面30例疗效分析[J]. 深圳中西医结合杂志,2016,26(14):87-88. DOI: 10.16458/j.cnki.1007-0893.2016.14.042.
    [15]
    郭慧芳. Ⅱ度烫伤患儿应用异种脱细胞真皮基质覆盖治疗的效果评价[J].中国美容医学,2018,27(10):59-62.
    [16]
    赵飞龙,裴丽丽,卢朋松. ADM包扎治疗Ⅱ度烧伤创面临床效果观察及安全性评价[J]. 医药界,2019(15):5.
    [17]
    陆金云. 异种脱细胞真皮基质在深Ⅱ度烧伤创面处理中的应用分析[J]. 浙江创伤外科,2020,25(5):948-949. DOI: 10.3969/j.issn.1009-7147.2020.05.061.
    [18]
    成鑫,汤俊. 新型生物敷料结合VSD对Ⅱ度烧伤创面恢复及炎性应激反应的影响[J]. 药物生物技术,2020,27(1):52-55. DOI: 10.19526/j.cnki.1005-8915.20200111.
    [19]
    谢晓勇,袁海源,沈胜生. 异种脱细胞真皮基质敷料对深Ⅱ度烧伤创面愈合的临床疗效[J]. 中外医学研究,2020,18(9):160-161. DOI: 10.14033/j.cnki.cfmr.2020.09.064.
    [20]
    万能,杨卫玺,程宏宇,等.异种(猪)脱细胞真皮基质敷料联合创面薄化修复深Ⅱ度烧伤创面对机体炎症水平的影响[J].中国美容医学,2020,29(10):57-60.
    [21]
    林桂清,刘平洪,黄锦刚,等. 异种脱细胞真皮基质敷料对深度烧伤患者创面愈合及瘢痕增生的影响[J]. 中外医学研究,2021,19(20):146-148. DOI: 10.14033/j.cnki.cfmr.2021.20.051.
    [22]
    SimpsonAM, HigdonKK, KilgoMS, et al. Porcine acellular peritoneal matrix in immediate breast reconstruction: a multicenter, prospective, single-arm trial[J]. Plast Reconstr Surg, 2019,143(1):10e-21e. DOI: 10.1097/PRS.0000000000005095.
    [23]
    崔泽龙,杨小辉,首家保,等. 瘢痕断层皮片联合脱细胞异体真皮治疗大面积深Ⅱ度烧伤瘢痕的疗效[J]. 中国修复重建外科杂志,2014,28(12):1502-1504. DOI: 10.7507/1002-1892.20140325.
    [24]
    ShangF,HouQ.Effects of allogenic acellular dermal matrix combined with autologous razor-thin graft on hand appearance and function of patients with extensive burn combined with deep hand burn[J].Int Wound J,2021,18(3):279-286.DOI: 10.1111/iwj.13532.
    [25]
    ChenXD,ShiY,ShuB,et al.The effect of porcine ADM to improve the burn wound healing[J].Int J Clin Exp Pathol,2013,6(11):2280-2291.
    [26]
    朱柯颖,郭瑢,陈德滇,等. 脱细胞真皮基质在临床治疗中的应用[J]. 中国组织工程研究,2022,26(34):5512-5517.
    [27]
    张伟杰磨痂联合异种脱细胞真皮基质覆盖在儿童烫伤中的应用衡阳南华大学2020

    张伟杰.磨痂联合异种脱细胞真皮基质覆盖在儿童烫伤中的应用[D]. 衡阳:南华大学,2020.

    [28]
    PowersJG,HighamC,BroussardK,et al.Wound healing and treating wounds: chronic wound care and management[J].J Am Acad Dermatol,2016,74(4):607-625; quiz 625-626.DOI: 10.1016/j.jaad.2015.08.070.
    [29]
    YuYL,AlkhawajiA,DingYQ,et al.Decellularized scaffolds in regenerative medicine[J].Oncotarget,2016,7(36):58671-58683.DOI: 10.18632/oncotarget.10945.
    [30]
    LeeLF,PorchJV,SpenlerW,et al.Integra in lower extremity reconstruction after burn injury[J].Plast Reconstr Surg,2008,121(4):1256-1262.DOI: 10.1097/01.prs.0000304237.54236.66.
    [31]
    HermansMHE.Porcine xenografts vs. (cryopreserved) allografts in the management of partial thickness burns: is there a clinical difference?[J].Burns,2014,40(3):408-415.DOI: 10.1016/j.burns.2013.08.020.
    [32]
    KishikovaL,SmithMD,CubisonTC.Evidence based management for paediatric burn: new approaches and improved scar outcomes[J].Burns,2014,40(8):1530-1537.DOI: 10.1016/j.burns.2014.01.020.
    [33]
    MansillaE,SpretzR,LarsenG,et al.Outstanding survival and regeneration process by the use of intelligent acellular dermal matrices and mesenchymal stem cells in a burn pig model[J].Transplant Proc,2010,42(10):4275-4278.DOI: 10.1016/j.transproceed.2010.09.132.
    [34]
    RowanMP,CancioLC,ElsterEA,et al.Burn wound healing and treatment: review and advancements[J].Crit Care,2015,19:243.DOI: 10.1186/s13054-015-0961-2.
    [35]
    WangYW, BeekmanJ, HewJ, et al. Burn injury: challenges and advances in burn wound healing, infection, pain and scarring[J]. Adv Drug Deliv Rev, 2018,123:3-17. DOI: 10.1016/j.addr.2017.09.018.
    [36]
    LadhaniHA, YowlerCJ, ClaridgeJA. Burn wound colonization, infection, and sepsis[J]. Surg Infect (Larchmt), 2021,22(1):44-48. DOI: 10.1089/sur.2020.346.
    [37]
    FangTL,LineaweaverWC,SailesFC,et al.Clinical application of cultured epithelial autografts on acellular dermal matrices in the treatment of extended burn injuries[J].Ann Plast Surg,2014,73(5):509-515.DOI: 10.1097/SAP.0b013e3182840883.
    [38]
    OgawaY,KawamuraT,ShimadaS.Zinc and skin biology[J].Arch Biochem Biophys,2016,611:113-119.DOI: 10.1016/j.abb.2016.06.003.
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