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2023 Vol. 39, No. 2

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Some thoughts on the research of mesenchymal stem cell exosomes and wound microenvironment
Wang Dali
2023, 39(2): 101-105. doi: 10.3760/cma.j.cn501225-20230112-00014
Abstract [FullText HTML] PDF
Abstract:
Since researchers have found that the conditioned medium and exosomes of mesenchymal stem cells (MSCs) had the biological effects equivalent to those of MSCs, MSC exosomes (MSC-Exos), the representative product of MSCs' paracrine effect, have become the research focus of the "cell-free" therapy of M...
The regulatory role and related mechanisms of macrophages in wound healing
He Weifeng, Yan Lingfeng
2023, 39(2): 106-113. doi: 10.3760/cma.j.cn501225-20230110-00010
Abstract [FullText HTML] PDF
Abstract:
Wound healing is a complex process under precise regulation, including multiple stages such as inflammation, anti-inflammatory, and regeneration. Macrophages play an important regulatory role in the differentiated process of wound healing due to their obvious plasticity. If macrophages fail to expre...
Original Articles · Wound Healing and Its Regulation Mechanisms
A prospective study on application of human umbilical cord mesenchymal stem cells combined with autologous Meek microskin transplantation in patients with extensive burns
Yan Tiantian, Xiao Rong, Wang Ying, Lin Guo'an, Zheng Yin, Zhao Hui, Li Wenjun, Shang Xinzhi, Meng Jinsong, Hu Dongsheng, Li Song, Wang Chao, Lin Zhichen, Chen Hongchang, Zhao Dongyan, Tang Di
2023, 39(2): 114-121. doi: 10.3760/cma.j.cn501225-20220728-00319
Abstract [FullText HTML] PDF
Abstract:
Objective To investigate the effects of human umbilical cord mesenchymal stem cells (hUCMSCs) combined with autologous Meek microskin transplantation on patients with extensive burns. Methods The prospective self-controlled study was conducted. From May 2019 to June 2022, 16 patients with extensive ...
Effects of tumor necrosis factor-alpha/extracellular signal-regulated kinase pathway on migration ability of HaCaT cells and full-thickness skin defects in mice
Zhao Shihan, Jin Linbo, Zhang Jianghe, Zhang Yiming, Fan Dongli
2023, 39(2): 122-131. doi: 10.3760/cma.j.cn501225-20221019-00460
Abstract [FullText HTML] PDF
Abstract:
Objective To investigate the effects of tumor necrosis factor-alpha (TNF-α)/extracellular signal-regulated kinase (ERK) pathway on the migration ability of HaCaT cells and full-thickness skin defects in mice. Methods The experimental research method was adopted. According to the random number table ...
Influence of autologous adipose stem cell matrix gel on wound healing and scar hyperplasia of full-thickness skin defects in rabbit ears
Li Liang, Bai Nan, Fu Yanjie, Wu Can, Zhang Yujiao, Chen Yuanzheng
2023, 39(2): 132-140. doi: 10.3760/cma.j.cn501225-20221020-00463
Abstract [FullText HTML] PDF
Abstract:
Objective To investigate the influence of autologous adipose stem cell matrix gel on wound healing and scar hyperplasia of full-thickness skin defects in rabbit ears, and to analyze the related mechanism. Methods Experimental research methods were adopted. The complete fat pads on the back of 42 mal...
Original Article·Innovative Technologies and Concepts
A prospective study of the perforator evaluation and eccentric design of anterolateral thigh flap based on superficial fascial perforators assisted by modified computed tomography angiography
Zhang Yueheng, Cui Wenju, Song Kunxiu, Sun Legang, Wang Fang, Liu Xiaozhi, Deng Zhiyang, Zhang Zhiqiang, Liu Yongtao
2023, 39(2): 141-149. doi: 10.3760/cma.j.cn501225-20220902-00376
Abstract [FullText HTML] PDF
Abstract:
Objective To explore the preoperative whole perforator evaluation and intraoperative eccentric design of anterolateral thigh flap (ALTF) based on superficial fascial perforators by modified computed tomography angiography (CTA), and the clinical effects were observed. Methods A prospective observati...
Original Articles
A prospective study on the expansion rule of the directional skin and soft tissue expander in abdominal scar reconstruction
Xue Jidong, Liang Yan, Xing Peipeng, Di Haiping, Zhang Jian, Yang Gaoyuan, Xia Chengde
2023, 39(2): 150-157. doi: 10.3760/cma.j.cn501120-20211123-00392
Abstract [FullText HTML] PDF
Abstract:
Objective To observe the expansion rule of directional skin and soft tissue expander (hereinafter referred to as expander) in abdominal scar reconstruction. Methods A prospective self-controlled study was conducted. Twenty patients with abdominal scar who met the inclusion criteria and admitted to Z...
A prospective study on the development and application verification of the quantitative evaluation software for three-dimensional morphology of pathological scars based on photo modeling technology
Jiang Weiqian, Pan Feng, Chai Mi, Wulan Hasi, Yu Xuedong, Guo Lingli
2023, 39(2): 158-164. doi: 10.3760/cma.j.cn501225-20220513-00184
Abstract [FullText HTML] PDF
Abstract:
Objective To develop a quantitative evaluation software for three-dimensional morphology of pathological scars based on photo modeling technology, and to verify its accuracy and feasibility in clinical application. Methods The method of prospective observational study was adopted. From April 2019 to...
Effects of three-dimensional bioprinting antibacterial hydrogel on full-thickness skin defect wounds in rats
Jin Ronghua, Zhang Zhenzhen, Xu Pengqin, Xia Sizhan, Weng Tingting, Zhu Zhikang, Wang Xingang, You Chuangang, Han Chunmao
2023, 39(2): 165-174. doi: 10.3760/cma.j.cn501120-20210809-00274
Abstract [FullText HTML] PDF
Abstract:
Objective To explore the effects of three-dimensional (3D) bioprinting gelatin methacrylamide (GelMA) hydrogel loaded with nano silver on full-thickness skin defect wounds in rats. Methods The experimental research method was adopted. The morphology, particle diameter, and distribution of silver nan...
Meta-analysis of the effects of xenogeneic acellular dermal matrix dressings in the treatment of wounds in burn patients
You Aijia, Li Wenjie, Zhou Junli, Li Chun
2023, 39(2): 175-183. doi: 10.3760/cma.j.cn501120-20220106-00008
Abstract [FullText HTML] PDF
Abstract:
Objective To evaluate the efficacy and safety of xenogeneic acellular dermal matrix (ADM) dressings for the treatment of wounds in burn patients. Methods The meta-analysis method was adopted. Databases including Chinese Journal Full-text Database, Wanfang Database, VIP Database, and Chinese Biomedic...
Reviews · Wound Healing and Its Regulation Mechanisms
Research advances on the mechanism of non-coding RNA regulated diabetic wound healing
Li Xiaoliang, Xie Jiangfan, Ye Xiangyang, Li Yanguang, Liu Dewu
2023, 39(2): 184-189. doi: 10.3760/cma.j.cn501225-20221101-00477
Abstract [FullText HTML] PDF
Abstract:
Diabetic wounds are a common complication of diabetic patients, and the incidence has been increasing in recent years. In addition, its poor clinical prognosis seriously affects the quality of life of patients, which has become the focus and difficulty of diabetes treatment. As the RNA regulating ge...
Research advances on the mechanism of Wnt/β-catenin signaling pathway in body surface wound healing
Wu Qian, Tan Xiaoyu, Wang Yijia, Cheng Shaowen, Cui Hongwang, Yao Jiangling
2023, 39(2): 190-195. doi: 10.3760/cma.j.cn501225-20220816-00348
Abstract [FullText HTML] PDF
Abstract:
Wound healing is a slow and complex biological process, including inflammatory reaction, cell proliferation, cell differentiation, cell migration, angiogenesis, extracellular matrix deposition, tissue remodeling, and so on. Wnt signaling pathway can be divided into classical pathway and non-classica...
Review
Research advances on the role and mechanism of microRNA in hypertrophic scar
Tian Wenrong, Zuo Jun, Ai Jiang, Qi Yusong, Bu Panpan, Zhao Jiaojun, Yu Yang, Ma Shaolin
2023, 39(2): 196-200. doi: 10.3760/cma.j.cn501225-20220508-00179
Abstract [FullText HTML] PDF
Abstract:
Hypertrophic scar (HS) affects the function and beauty of patients, and brings a heavy psychological burden to patients. However, the specific pathogenesis mechanism of HS in molecular biology level is not yet clear, and this disease is still one of the clinical diseases difficult to prevent and cur...

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