Volume 39 Issue 5
May  2023
Turn off MathJax
Article Contents
Tian GL,Cheng B,Fu XB.Role and prospect of regenerative medicine in early treatment of combat trauma[J].Chin J Burns Wounds,2023,39(5):411-416.DOI: 10.3760/cma.j.cn501225-20220419-00147.
Citation: Tian GL,Cheng B,Fu XB.Role and prospect of regenerative medicine in early treatment of combat trauma[J].Chin J Burns Wounds,2023,39(5):411-416.DOI: 10.3760/cma.j.cn501225-20220419-00147.

Role and prospect of regenerative medicine in early treatment of combat trauma

doi: 10.3760/cma.j.cn501225-20220419-00147
Funds:

General Program of National Natural Science Foundation of China 82172223

Military Medical Innovation Special Project 18CXZ029

More Information
  • The regenerative medicine has made great breakthrough in the repair of combat trauma, showing broad prospects, while the method of regenerative medicine applied in the early treatment of combat trauma is not yet clear. The early treatment of combat trauma includes strict control of bleeding, a large amount of blood transfusion, alleviation of acidosis, and correction of hypothermia and improvement of coagulation dysfunction, etc. This paper focuses on the bio-engineered blood, research and development of homeostatic materials, control of inflammation/infection, regulation of immunity, protection of important organs, establishment of military medical model, research and development of biosensors and drugs, and preventive application of stem cell bank in regenerative and tissue engineering in defense medicine to summarize the role of regenerative medicine in the early treatment of combat trauma, hoping to improve the overall treatment level of combat trauma.

     

  • loading
  • [1]
    付小兵.中国组织修复与再生医学健康发展的思考与实践[J].中华创伤杂志,2021,37(7):580-585.DOI: 10.3760/cma.j.cn501098-20210525-00319.
    [2]
    UdeCC,MiskonA,IdrusR,et al.Application of stem cells in tissue engineering for defense medicine[J].Mil Med Res,2018,5(1):7.DOI: 10.1186/s40779-018-0154-9.
    [3]
    ChewLH, DhillonP. Identifying type Os: spelling out the future of red blood cell products in military medicine[J]. J Military, Veteran Family Health, 2022,8 (s2): 123-131. DOI: 10.3138/jmvfh-2021-0123.
    [4]
    CapAP,CannonJW,ReadeMC.Synthetic blood and blood products for combat casualty care and beyond[J].J Trauma Acute Care Surg,2021,91(2S Suppl 2):S26-32.DOI: 10.1097/TA.0000000000003248.
    [5]
    KhanF,SinghK,FriedmanMT.Artificial blood: the history and current perspectives of blood substitutes[J].Discoveries (Craiova),2020,8(1):e104.DOI: 10.15190/d.2020.1.
    [6]
    LucNF,RohnerN,GirishA,et al.Bioinspired artificial platelets: past, present and future[J].Platelets,2022,33(1):35-47.DOI: 10.1080/09537104.2021.1967916.
    [7]
    PopovskyMA,WhiteN.Spray-dried plasma: a post-traumatic blood "bridge" for life-saving resuscitation[J].Transfusion,2021,61 Suppl 1:S294-300.DOI: 10.1111/trf.16536.
    [8]
    MokG,HoangR,KhanMW,et al.Freeze-dried plasma for major trauma - systematic review and meta-analysis[J].J Trauma Acute Care Surg,2021,90(3):589-602.DOI: 10.1097/TA.0000000000003012.
    [9]
    PusateriAE, WeiskopfRB.Dried plasma for trauma resuscitation[J]. Plasma, 2021:705-718. DOI: 10.1007/978-3-030-53606-0_42.
    [10]
    郭栋,张戎,黎檀实,等.现代战伤现场急救止血理论、技术与器材[J].中华灾害救援医学,2021,9(6):1066-1070.DOI: 10.13919/j.issn.2095-6274.2021.06.011.
    [11]
    Feingerts B Efficacy of QuikClot combat gauze when used by immediate responders in a simulated gunshot wound Connecticut Yale School of Medicine 2021

    FeingertsB. Efficacy of QuikClot combat gauze when used by immediate responders in a simulated gunshot wound[D]. Connecticut:Yale School of Medicine,2021.

    [12]
    YuP,ZhongW.Hemostatic materials in wound care[J/OL].Burns Trauma,2021,9:tkab019[2022-04-19].https://pubmed.ncbi.nlm.nih.gov/34541007/.DOI: 10.1093/burnst/tkab019.
    [13]
    AnsariA, KhosronezhadF, ShallagehY, et al. A review of hemostatic agents and products[J]. Scientific J Iran Blood Transfus Organ, 2021, 18(4): 291-312.
    [14]
    TompeckAJ,GajdharAUR,DowlingM,et al.A comprehensive review of topical hemostatic agents: the good, the bad, and the novel[J].J Trauma Acute Care Surg,2020,88(1):e1-e21.DOI: 10.1097/TA.0000000000002508.
    [15]
    MalikA,RehmanFU,ShahKU,et al.Hemostatic strategies for uncontrolled bleeding: a comprehensive update[J].J Biomed Mater Res B Appl Biomater,2021,109(10):1465-1477.DOI: 10.1002/jbm.b.34806.
    [16]
    GhimireS,SarkarP,RigbyK,et al.Polymeric materials for hemostatic wound healing[J].Pharmaceutics,2021,13(12):2127.DOI: 10.3390/pharmaceutics13122127.
    [17]
    MohamedE, FitzgeraldA, TsuzukiT. The role of nanoscale structures in the development of topical hemostatic agents[J]. Materials Today Nano, 2021, 16: 100137.DOI: 10.1016/j.mtnano.2021.100137.
    [18]
    SheppardOO,FojeNA.Topical coagulant agents[J].Surg Clin North Am,2022,102(1):65-83.DOI: 10.1016/j.suc.2021.09.004.
    [19]
    PelteCH,ChawlaLS.Novel therapeutic targets for prevention and therapy of sepsis associated acute kidney injury[J].Curr Drug Targets,2009,10(12):1205-1211.DOI: 10.2174/138945009789753219.
    [20]
    AmbroseCG, KellamJF, CrawfordL, et al. Incidence, complications, and novel treatment strategies: osteomyelitis[J]. Musculoskeletal Infection, 2022:203-225. DOI: 10.1007/978-3-030-83251-3_7.
    [21]
    Ayala-CuellarAP,KangJH,JeungEB,et al.Roles of mesenchymal stem cells in tissue regeneration and immunomodulation[J].Biomol Ther (Seoul),2019,27(1):25-33.DOI: 10.4062/biomolther.2017.260.
    [22]
    HarrellCR,DjonovV,VolarevicV.The cross-talk between mesenchymal stem cells and immune cells in tissue repair and regeneration[J].Int J Mol Sci,2021,22(5):2472.DOI: 10.3390/ijms22052472.
    [23]
    LiT,LuoC,ZhangJ,et al.Efficacy and safety of mesenchymal stem cells co-infusion in allogeneic hematopoietic stem cell transplantation: a systematic review and meta-analysis[J].Stem Cell Res Ther,2021,12(1):246.DOI: 10.1186/s13287-021-02304-x.
    [24]
    ShahK,ShahN,GhassemiF,et al.Alloreactivity of allogeneic mesenchymal stem/stromal cells and other cellular therapies: a concise review[J].Stem Cells Int,2022,2022:9589600.DOI: 10.1155/2022/9589600.
    [25]
    SalatiSA. Debridement-a review of current techniques[J]. Journal of Pakistan Association of Dermatologists, 2021, 31(2): 262-272.
    [26]
    DrydenM.Novel techniques in the treatment of skin and soft tissue infection[J].Curr Opin Infect Dis,2022,35(2):72-78.DOI: 10.1097/QCO.0000000000000818.
    [27]
    SatyamitraMM,CassattDR,TaliaferroLP.Meeting commentary: a poly-pharmacy approach to mitigate acute radiation syndrome (ARS)[J].Radiat Res,2021,196(4):423-428.DOI: 10.1667/RADE-21-00053.1.
    [28]
    ChangC,YanJ,YaoZ,et al.Effects of mesenchymal stem cell-derived paracrine signals and their delivery strategies[J].Adv Healthc Mater,2021,10(7):e2001689.DOI: 10.1002/adhm.202001689.
    [29]
    DiCarloAL, TamaratR, RiosCI, et al. Cellular therapies for treatment of radiation injury: report from a NIH/NIAID and IRSN workshop[J]. Radiat Res, 2017,188(2):e54-e75. DOI: 10.1667/RR14810.1.
    [30]
    WangS,HanY,ZhangJ,et al.Me6TREN targets β-catenin signaling to stimulate intestinal stem cell regeneration after radiation[J].Theranostics,2020,10(22):10171-10185.DOI: 10.7150/thno.46415.
    [31]
    MizutaY,AkahoshiT,GuoJ,et al.Exosomes from adipose tissue-derived mesenchymal stem cells ameliorate histone-induced acute lung injury by activating the PI3K/Akt pathway in endothelial cells[J].Stem Cell Res Ther,2020,11(1):508.DOI: 10.1186/s13287-020-02015-9.
    [32]
    付小兵.组织修复与再生的新挑战:实现多种组织在损伤部位的同步修复与再生[J].中华烧伤杂志,2016,32(1):6-10.DOI: 10.3760/cma.j.issn.1009-2587.2016.01.003.
    [33]
    YahayaU, AkramM, AbdullahiRI, et al. The role of biosensors and biological weapons in national defence and security operations[J]. Nig J Biotech, 2021, 38(1): 132-136.DOI: 10.4314/njb.v38i1.15.
    [34]
    RouxJ,ZeghidiM,VillarS,et al.Biosafety and biobanking: current understanding and knowledge gaps[J].Biosaf Health,2021,3(5):244-248.DOI: 10.1016/j.bsheal.2021.06.003.
    [35]
    SittadjodyS,CriswellT,JacksonJD,et al.Regenerative medicine approaches in bioengineering female reproductive tissues[J].Reprod Sci,2021,28(6):1573-1595.DOI: 10.1007/s43032-021-00548-9.
    [36]
    Al-HendyA,KuSY.Reproductive tract tissue/organ engineering and regenerative medicine for reproduction[J].Reprod Sci,2021,28(6):1571-1572.DOI: 10.1007/s43032-021-00547-w.
    [37]
    BhaskarR, GuptaMK, HanSS. Tissue engineering approaches for the in vitro production of spermatids to treat male infertility: a review[J]. European Polymer Journal, 2022,174:111318.DOI.10.1016/j.eurpolymj.2022.111318.
    [38]
    ZhouP,OuchariM,XueY,et al.In vitro generation of red blood cells from stem cell and targeted therapy[J].Cell Transplant,2020,29:963689720946658.DOI: 10.1177/0963689720946658.
    [39]
    ÖztürkS,ElçinAE,KocaA,et al.Therapeutic applications of stem cells and extracellular vesicles in emergency care: futuristic perspectives[J].Stem Cell Rev Rep,2021,17(2):390-410.DOI: 10.1007/s12015-020-10029-2.
    [40]
    KellyLS, DardenDB, FennerBP, et al. The hematopoietic stem/progenitor cell response to hemorrhage, injury, and sepsis: a review of pathophysiology[J]. Shock, 2021, 56(1): 30-41.DOI: 10.1097/SHK.0000000000001699.
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Figures(1)

    Article Metrics

    Article views (283) PDF downloads(39) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return