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Volume 39 Issue 4
Apr.  2023
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Article Navigation >  CHINESE JOURNAL OF BURNS AND WOUNDS  > 2023  >  39(4): 396-400
Huang SY,Zhu F,Guo GH.Research advances on the role of complement system activation in post-burn immunity[J].Chin J Burns Wounds,2023,39(4):396-400.DOI: 10.3760/cma.j.cn501225-20220726-00313.
Citation: Huang SY,Zhu F,Guo GH.Research advances on the role of complement system activation in post-burn immunity[J].Chin J Burns Wounds,2023,39(4):396-400.DOI: 10.3760/cma.j.cn501225-20220726-00313.
shu

Research advances on the role of complement system activation in post-burn immunity

doi: 10.3760/cma.j.cn501225-20220726-00313
  • 1.

    Medical Center of Burn Plastic and Wound Repair, the First Affiliated Hospital of Nanchang University, Nanchang 330006, China

  • 2.

    Burn Department, the First Affiliated Hospital, Naval Medical University, Shanghai 200433, China

Funds:

National Key Research and Development Program of China 2019YFA0110601

Regional Science Foundation Program of National Natural Science Foundation of China 82160376, 81760342, 81960352

Key Program for Key Research and Development Program of Science and Technology Department of Jiangxi Province of China 20171ACG70004

Youth Science Fund Project of Jiangxi Province of China 20192BAB215029

More Information
    Abstract
  • Immune activation is one of the major factors of secondary injury post burn, and is the main organismal response in the anti-infection process. As an important part of the innate immune response, the complement system is able to induce the activation of immune cells after burns, promote inflammation and mediate the breakdown of the immune barrier, and even engage in complex cross-linking with the coagulation cascade. This article reviews the role of complement system activation in post-burn immunity and its possibility of clinical translation from the perspectives of innate immunity, acquired immunity, and cross-linking of the complement system with the coagulation cascade.

     

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