Volume 39 Issue 5
May  2023
Turn off MathJax
Article Contents
Nong YL,Lyu YH.Research advances on the mechanism of circular RNA in diabetic wound healing[J].Chin J Burns Wounds,2023,39(5):487-490.DOI: 10.3760/cma.j.cn501225-20220727-00317.
Citation: Nong YL,Lyu YH.Research advances on the mechanism of circular RNA in diabetic wound healing[J].Chin J Burns Wounds,2023,39(5):487-490.DOI: 10.3760/cma.j.cn501225-20220727-00317.

Research advances on the mechanism of circular RNA in diabetic wound healing

doi: 10.3760/cma.j.cn501225-20220727-00317
Funds:

National Training Program for College Students′ Innovation 202210262013

Shanghai Sailing Program 21YF1418800

More Information
  • In recent years, a large number of studies have shown that non-coding RNAs play an important role in wound healing process. Among them, studies on the mechanism of circular RNA (circRNA) have shown that circRNA is closely related to the proliferation of cells related to wound healing, such as endothelial progenitor cells and keratinocytes, and circRNA is also involved in the chronic wound healing process. Based on the introduction of the related concept of circRNA, this paper focuses on the possible regulatory mechanism of circRNA in different stages of diabetic wound healing and summarizes the potential role of circRNA in the process of diabetic peripheral vascular atherosclerosis, aiming to explore the in-depth molecular mechanism and clinical significance of circRNA in diabetic wound healing process, and provide reference for further research.

     

  • loading
  • [1]
    SorgH,TilkornDJ,HagerS,et al.Skin wound healing: an update on the current knowledge and concepts[J].Eur Surg Res,2017,58(1/2):81-94.DOI: 10.1159/000454919.
    [2]
    WangA,LvG,ChengX,et al.Guidelines on multidisciplinary approaches for the prevention and management of diabetic foot disease (2020 edition)[J/OL].Burns Trauma, 2020,8:tkaa017[2022-07-27]. https://academic.oup.com/burnstrauma/article/doi/ 10.1093/burnst/tkaa017/5867664?searchresult=1.DOI: 10.1093/burnst/tkaa017.
    [3]
    ZhangP,WuW,ChenQ,et al.Non-coding RNAs and their integrated networks[J].J Integr Bioinform,2019,16(3):20190027.DOI: 10.1515/jib-2019-0027.
    [4]
    王鹏,尹斌,苏映军,等.长链非编码RNA介导慢性难愈性创面愈合的机制研究进展[J].中华烧伤杂志,2020,36(8):758-761.DOI: 10.3760/cma.j.cn501120-20190526-00254.
    [5]
    FahsF,BiX,YuFS,et al.New insights into microRNAs in skin wound healing[J].IUBMB Life,2015,67(12):889-896.DOI: 10.1002/iub.1449.
    [6]
    廖银友,张丕红.竞争性内源性RNA在创面愈合中作用的研究进展[J].中华烧伤与创面修复杂志,2022,38(1):84-89.DOI: 10.3760/cma.j.cn501120-20201125-00498.
    [7]
    AlaU.Competing endogenous RNAs, non-coding RNAs and diseases: an intertwined story[J].Cells,2020,9(7):1574.DOI: 10.3390/cells9071574.
    [8]
    KristensenLS,AndersenMS,StagstedLVM,et al.The biogenesis, biology and characterization of circular RNAs[J].Nat Rev Genet,2019,20(11):675-691.DOI: 10.1038/s41576-019-0158-7.
    [9]
    MumtazPT,TabanQ,DarMA,et al.Deep insights in circular RNAs: from biogenesis to therapeutics[J].Biol Proced Online,2020,22:10.DOI: 10.1186/s12575-020-00122-8.
    [10]
    Rybak-WolfA,StottmeisterC,GlažarP,et al.Circular RNAs in the mammalian brain are highly abundant, conserved, and dynamically expressed[J].Mol Cell,2015,58(5):870-885.DOI: 10.1016/j.molcel.2015.03.027.
    [11]
    HansenTB,KjemsJ,DamgaardCK.Circular RNA and miR-7 in cancer[J].Cancer Res,2013,73(18):5609-5612.DOI: 10.1158/0008-5472.CAN-13-1568.
    [12]
    LiZ,HuangC,BaoC,et al.Exon-intron circular RNAs regulate transcription in the nucleus[J].Nat Struct Mol Biol,2015,22(3):256-264.DOI: 10.1038/nsmb.2959.
    [13]
    LegniniI,Di TimoteoG,RossiF,et al.Circ-ZNF609 is a circular RNA that can be translated and functions in myogenesis[J].Mol Cell,2017,66(1):22-37.e9.DOI: 10.1016/j.molcel.2017.02.017
    [14]
    WangY,MoY,PengM,et al.The influence of circular RNAs on autophagy and disease progression[J].Autophagy,2022,18(2):240-253.DOI: 10.1080/15548627.2021.1917131.
    [15]
    HaqueS,AmesRM,MooreK,et al.circRNAs expressed in human peripheral blood are associated with human aging phenotypes, cellular senescence and mouse lifespan[J].Geroscience,2020,42(1):183-199.DOI: 10.1007/s11357-019-00120-z.
    [16]
    ShanK,LiuC,LiuBH,et al.Circular noncoding RNA HIPK3 mediates retinal vascular dysfunction in diabetes mellitus[J].Circulation,2017,136(17):1629-1642.DOI: 10.1161/CIRCULATIONAHA.117.029004.
    [17]
    LiuJ,DuanP,XuC,et al.CircRNA circ-ITCH improves renal inflammation and fibrosis in streptozotocin-induced diabetic mice by regulating the miR-33a-5p/SIRT6 axis[J].Inflamm Res,2021,70(7):835-846.DOI: 10.1007/s00011-021-01485-8.
    [18]
    HanG,CeilleyR.Chronic wound healing: a review of current management and treatments[J].Adv Ther,2017,34(3):599-610.DOI: 10.1007/s12325-017-0478-y.
    [19]
    LiY,ChengT,WanC,et al.circRNA_0084043 contributes to the progression of diabetic retinopathy via sponging miR-140-3p and inducing TGFA gene expression in retinal pigment epithelial cells[J].Gene,2020,747:144653.DOI: 10.1016/j.gene.2020.144653.
    [20]
    FengT,LiW,LiT,et al.Circular RNA_0037128 aggravates high glucose-induced damage in HK-2 cells via regulation of microRNA-497-5p/nuclear factor of activated T cells 5 axis[J].Bioengineered,2021,12(2):10959-10970.DOI: 10.1080/21655979.2021.2001912.
    [21]
    DaiH,HuF,YangX,et al.Hsa_circ_0054633 association of C peptide is related to IL-17 and TNF-α in patients with diabetes mellitus receiving insulin treatment[J].J Clin Lab Anal,2021,35(8):e23856.DOI: 10.1002/jcla.23856.
    [22]
    ZhaoL,ChenH,ZengY,et al.Circular RNA circ_0000712 regulates high glucose-induced apoptosis, inflammation, oxidative stress, and fibrosis in (DN) by targeting the miR-879-5p/SOX6 axis[J].Endocr J,2021,68(10):1155-1164.DOI: 10.1507/endocrj.EJ20-0739.
    [23]
    YangD,LiM,DuN.Effects of the circ_101238/miR-138-5p/CDK6 axis on proliferation and apoptosis keloid fibroblasts[J].Exp Ther Med,2020,20(3):1995-2002.DOI: 10.3892/etm.2020.8917.
    [24]
    LiJ,LiP,ZhangG,et al.CircRNA TADA2A relieves idiopathic pulmonary fibrosis by inhibiting proliferation and activation of fibroblasts[J].Cell Death Dis,2020,11(7):553.DOI: 10.1038/s41419-020-02747-9.
    [25]
    HeZ,XuX.Circ_0084443 inhibits wound healing via repressing keratinocyte migration through targeting the miR-17-3p/FOXO4 axis[J].Biochem Genet,2022,60(4):1236-1252.DOI: 10.1007/s10528-021-10157-5.
    [26]
    WangA,TomaMA,MaJ,et al.Circular RNA hsa_circ_0084443 is upregulated in diabetic foot ulcer and modulates keratinocyte migration and proliferation[J].Adv Wound Care (New Rochelle),2020,9(4):145-160.DOI: 10.1089/wound.2019.0956.
    [27]
    HanD,LiuW,LiG,et al.Circ_PRKDC knockdown promotes skin wound healing by enhancing keratinocyte migration via miR-31/FBN1 axis[J].J Mol Histol,2021,52(4):681-691.DOI: 10.1007/s10735-021-09996-8.
    [28]
    ShangB,XuT,HuN,et al.Circ-Klhl8 overexpression increased the therapeutic effect of EPCs in diabetic wound healing via the miR-212-3p/SIRT5 axis[J].J Diabetes Complications,2021,35(11):108020.DOI: 10.1016/j.jdiacomp.2021.108020.
    [29]
    ShiR,JinY,HuW,et al.Exosomes derived from mmu_circ_0000250-modified adipose-derived mesenchymal stem cells promote wound healing in diabetic mice by inducing miR-128-3p/SIRT1-mediated autophagy[J].Am J Physiol Cell Physiol,2020,318(5):C848-C856.DOI: 10.1152/ajpcell.00041.2020.
    [30]
    WangZ,FengC,LiuH,et al.Hypoxic pretreatment of adipose-derived stem cells accelerates diabetic wound healing via circ-Gcap14 and HIF-1α/VEGF mediated angiopoiesis[J].Int J Stem Cells,2021,14(4):447-454.DOI: 10.15283/ijsc21050.
    [31]
    沈冯洁,曹伟男,孟凡东,等.环状RNA hsa_circ_0018103在高糖诱导脂肪干细胞中的表达及其对细胞自噬及凋亡的影响[J].中国糖尿病杂志,2022,30(7):540-546.DOI: 10.3969/j.issn.1006-6187.2022.07.012.
    [32]
    万文辉.关注老年人个体共病状态的临床研究[J].中华老年多器官疾病杂志,2012,11(11):801-804.DOI: 10.3724/SP.J.1264.2012.00203.
    [33]
    BaiY,LiuF,YangZ.CircRNA LRP6 promotes high-glucose induced proliferation and migration of vascular smooth muscle cells through regulating miR-545-3p/HMGA1 signaling axis[J].Am J Transl Res,2021,13(8):8909-8920.
    [34]
    FanK,RuanX,WangL,et al.Circ_0004872 promotes platelet-derived growth factor-BB-induced proliferation, migration and dedifferentiation in HA-VSMCs via miR-513a-5p/TXNIP axis[J].Vascul Pharmacol,2021,140:106842.DOI: 10.1016/j.vph.2021.106842.
    [35]
    JiN,WangY,GongX,et al.CircMTO1 inhibits ox-LDL-stimulated vascular smooth muscle cell proliferation and migration via regulating the miR-182-5p/RASA1 axis[J].Mol Med,2021,27(1):73.DOI: 10.1186/s10020-021-00330-2.
    [36]
    LuoY,HuangC.CircSFMBT2 facilitates vascular smooth muscle cell proliferation by targeting miR-331-3p/HDAC5[J].Life Sci,2021,264:118691.DOI: 10.1016/j.lfs.2020.118691.
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Article Metrics

    Article views (202) PDF downloads(27) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return