Volume 39 Issue 5
May  2023
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Wei ZR,Dong Y,Li GS,et al.Research advances on the mechanism of oral mucosal stem cells in promoting wound healing[J].Chin J Burns Wounds,2023,39(5):496-500.DOI: 10.3760/cma.j.cn501225-20220730-00321.
Citation: Wei ZR,Dong Y,Li GS,et al.Research advances on the mechanism of oral mucosal stem cells in promoting wound healing[J].Chin J Burns Wounds,2023,39(5):496-500.DOI: 10.3760/cma.j.cn501225-20220730-00321.

Research advances on the mechanism of oral mucosal stem cells in promoting wound healing

doi: 10.3760/cma.j.cn501225-20220730-00321
Funds:

Science and Technology Development Plan Program of Henan Province of China 222102310188

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  • Wound healing is a complex process that requires the participation of multiple cells and cytokines. During the process of wound healing, abnormality in any stage of the process may lead to the development of a chronic refractory wound. Research has confirmed that various stem cells can promote wound healing, but some stem cells are limited in clinical application due to difficulties in isolation, susceptibility to apoptosis, ethical and legal issues. Oral mucosal stem cells (OMSCs) can avoid the above problems. This type of stem cells has the characteristics of embryonic stem cells, immune regulatory ability, and strong homogeneity. It plays an important role in the process of scarless oral wound healing, and has become a research hotspot in promoting wound healing and reducing scar formation. This article reviews the research on the mechanism, clinical application prospects, and current problems of OMSCs in promoting wound healing.

     

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  • [1]
    KanjiS,DasH.Advances of stem cell therapeutics in cutaneous wound healing and regeneration[J].Mediators Inflamm,2017,2017:5217967.DOI: 10.1155/2017/5217967.
    [2]
    SilveiraBM,RibeiroTO,FreitasRS,et al.Secretome from human adipose-derived mesenchymal stem cells promotes blood vessel formation and pericyte coverage in experimental skin repair[J].PLoS One,2022,17(12):e0277863.DOI: 10.1371/journal.pone.0277863.
    [3]
    BaruiA,ChowdhuryF,PanditA,et al.Rerouting mesenchymal stem cell trajectory towards epithelial lineage by engineering cellular niche[J].Biomaterials,2018,156:28-44.DOI: 10.1016/j.biomaterials.2017.11.036.
    [4]
    卢境婷,王旭东,代杰文,等.颅神经嵴细胞的迁移及特性[J/CD].中华口腔医学研究杂志:电子版,2011,5(6):652-657.DOI: 10.3877/cma.j.issn.1674-1366.2011.06.016.
    [5]
    JonesKB,KleinOD.Oral epithelial stem cells in tissue maintenance and disease: the first steps in a long journey[J].Int J Oral Sci,2013,5(3):121-129.DOI: 10.1038/ijos.2013.46.
    [6]
    FerréFC,LarjavaH,Loison-RobertLS,et al.Formation of cartilage and synovial tissue by human gingival stem cells[J].Stem Cells Dev,2014,23(23):2895-2907.DOI: 10.1089/scd.2013.0547.
    [7]
    LinardC,TissedreF,BussonE,et al.Therapeutic potential of gingival fibroblasts for cutaneous radiation syndrome: comparison to bone marrow-mesenchymal stem cell grafts[J].Stem Cells Dev,2015,24(10):1182-1193.DOI: 10.1089/scd.2014.0486.
    [8]
    SanzAR,CarriónFS,ChaparroAP.Mesenchymal stem cells from the oral cavity and their potential value in tissue engineering[J].Periodontol 2000,2015,67(1):251-267.DOI: 10.1111/prd.12070.
    [9]
    ArabpourM,SaghazadehA,RezaeiN.Anti-inflammatory and M2 macrophage polarization-promoting effect of mesenchymal stem cell-derived exosomes[J].Int Immunopharmacol,2021,97:107823.DOI: 10.1016/j.intimp.2021.107823.
    [10]
    MbongueJC,NicholasDA,TorrezTW,et al.The role of indoleamine 2, 3-dioxygenase in immune suppression and autoimmunity[J].Vaccines (Basel),2015,3(3):703-729.DOI: 10.3390/vaccines3030703.
    [11]
    GaoZ,GuanL,LiuZ,et al. Using extracellular vesicles derived from human umbilical cord mesenchymal stem cells for a topical coating promotes oral mucositis healing in rats[J].Ann Transl Med,2022,10(6):290.DOI: 10.21037/atm-22-767.
    [12]
    QuY,HeY,MengB,et al.Apoptotic vesicles inherit SOX2 from pluripotent stem cells to accelerate wound healing by energizing mesenchymal stem cells[J].Acta Biomater,2022,149:258-272.DOI: 10.1016/j.actbio.2022.07.009.
    [13]
    ParkHJ,LeeS,KangKH,et al.Enhanced random skin flap survival by sustained delivery of fibroblast growth factor 2 in rats[J].ANZ J Surg,2013,83(5):354-358.DOI: 10.1111/j.1445-2197.2012.06194.x.
    [14]
    BizenjimaT,SeshimaF,IshizukaY,et al.Fibroblast growth factor-2 promotes healing of surgically created periodontal defects in rats with early, streptozotocin-induced diabetes via increasing cell proliferation and regulating angiogenesis[J].J Clin Periodontol,2015,42(1):62-71.DOI: 10.1111/jcpe.12324.
    [15]
    肖健,张凡.生长因子调控创面修复的进展与思考[J].中华烧伤与创面修复杂志,2022,38(7):610-615.DOI: 10.3760/cma.j.cn501225-20220416-00139.
    [16]
    MiuraY,Ngo Thai BichV,FuruyaM,et al.The small G protein Arf6 expressed in keratinocytes by HGF stimulation is a regulator for skin wound healing[J].Sci Rep,2017,7:46649.DOI: 10.1038/srep46649.
    [17]
    ZhangJ,YangP,LiuD,et al.Inhibiting hyper-O-GlcNAcylation of c-Myc accelerate diabetic wound healing by alleviating keratinocyte dysfunction[J/OL].Burns Trauma,2021,9:tkab031[2022-07-30].https://pubmed.ncbi.nlm.nih.gov/34646892/.DOI: 10.1093/burnst/tkab031.
    [18]
    LeeYH,LinSJ.Chitosan/PVA hetero-composite hydrogel containing antimicrobials, perfluorocarbon nanoemulsions, and growth factor-loaded nanoparticles as a multifunctional dressing for diabetic wound healing: synthesis, characterization, and in vitro/in vivo evaluation[J].Pharmaceutics,2022,14(3):537.DOI: 10.3390/pharmaceutics14030537.
    [19]
    XieJ,WuX,ZhengS,et al.Aligned electrospun poly(L-lactide) nanofibers facilitate wound healing by inhibiting macrophage M1 polarization via the JAK-STAT and NF-κB pathways[J].J Nanobiotechnology,2022,20(1):342.DOI: 10.1186/s12951-022-01549-9.
    [20]
    ZengJ,ChenM,YangY,et al.A novel hypoxic lncRNA, HRL-SC, promotes the proliferation and migration of human dental pulp stem cells through the PI3K/AKT signaling pathway[J].Stem Cell Res Ther,2022,13(1):286.DOI: 10.1186/s13287-022-02970-5.
    [21]
    LiB,TangH,BianX,et al.Calcium silicate accelerates cutaneous wound healing with enhanced re-epithelialization through EGF/EGFR/ERK-mediated promotion of epidermal stem cell functions[J/OL].Burns Trauma,2021,9:tkab029[2022-07-30].https://pubmed.ncbi.nlm.nih.gov/34604395/.DOI: 10.1093/burnst/tkab029.
    [22]
    ChoJM,YoonYJ,LeeS,et al.Retroductal delivery of epidermal growth factor protects salivary progenitors after irradiation[J].J Dent Res,2021,100(8):883-890.DOI: 10.1177/0022034521999298.
    [23]
    翁婷婷,蔡程浩,韩春茂,等.生物材料递送生长因子调控创面修复的研究进展[J].中华烧伤与创面修复杂志,2022,38(7):691-696.DOI: 10.3760/cma.j.cn501225-20220430-00166.
    [24]
    DingDC,ShyuWC,LinSZ.Mesenchymal stem cells[J].Cell Transplant,2011,20(1):5-14.DOI: 10.3727/096368910X.
    [25]
    ZhouW,LinJ,ZhaoK,et al.Single-cell profiles and clinically useful properties of human mesenchymal stem cells of adipose and bone marrow origin[J].Am J Sports Med,2019,47(7):1722-1733.DOI: 10.1177/0363546519848678.
    [26]
    PriesterC,MacDonaldA,DharM,et al.Examining the characteristics and applications of mesenchymal, induced pluripotent, and embryonic stem cells for tissue engineering approaches across the germ layers[J].Pharmaceuticals (Basel),2020,13(11):344.DOI: 10.3390/ph13110344.
    [27]
    ChenMH,TaiWC,ChengNC,et al.Characterization of the stemness and osteogenic potential of oral and sinus mucosal cells[J].J Formos Med Assoc,2022,121(3):652-659.DOI: 10.1016/j.jfma.2021.06.017.
    [28]
    DangCM,BeanesSR,LeeH,et al.Scarless fetal wounds are associated with an increased matrix metalloproteinase-to-tissue-derived inhibitor of metalloproteinase ratio[J].Plast Reconstr Surg,2003,111(7):2273-2285.DOI: 10.1097/01.PRS.0000060102.57809.DA.
    [29]
    LegrandJMD,MartinoMM.Growth factor and cytokine delivery systems for wound healing[J].Cold Spring Harb Perspect Biol,2022,14(8):a041234.DOI: 10.1101/cshperspect.a041234.
    [30]
    JimiS,JaguparovA,NurkeshA,et al.Sequential delivery of cryogel released growth factors and cytokines accelerates wound healing and improves tissue regeneration[J].Front Bioeng Biotechnol,2020,8:345.DOI: 10.3389/fbioe.2020.00345.
    [31]
    PouraghaeiS,MoztarzadehF,ChenC,et al.Microenvironment can induce development of auditory progenitor cells from human gingival mesenchymal stem cells[J].ACS Biomater Sci Eng,2020,6(4):2263-2273.DOI: 10.1021/acsbiomaterials.9b01795.
    [32]
    IsaacJ,NassifA,AsselinA,et al.Involvement of neural crest and paraxial mesoderm in oral mucosal development and healing[J].Biomaterials,2018,172:41-53.DOI: 10.1016/j.biomaterials.2018.04.036.
    [33]
    EslamiA,Gallant-BehmCL,HartDA,et al.Expression of integrin αvβ6 and TGF-β in scarless vs scar-forming wound healing[J].J Histochem Cytochem,2009,57(6):543-557.DOI: 10.1369/jhc.2009.952572.
    [34]
    GlimJE,van EgmondM,NiessenFB,et al.Detrimental dermal wound healing: what can we learn from the oral mucosa?[J].Wound Repair Regen,2013,21(5):648-660.DOI: 10.1111/wrr.12072.
    [35]
    BacciS.Fine regulation during wound healing by mast cells, a physiological role not yet clarified[J].Int J Mol Sci,2022,23(3):1820.DOI: 10.3390/ijms23031820.
    [36]
    孔亮亮,王媛,施丽君,等.Bmi1对小鼠颅缝间充质细胞增殖能力的影响[J].中华整形外科杂志,2019,35(2):176-181.DOI: 10.3760/cma.j.issn.1009-4598.2019.02.015.
    [37]
    XueC,GaoY,LiX,et al.Mesenchymal stem cells derived from adipose accelerate the progression of colon cancer by inducing a MT-CAFs phenotype via TRPC3/NF-KB axis[J].Stem Cell Res Ther,2022,13(1):335.DOI: 10.1186/s13287-022-03017-5.
    [38]
    GreeneC,DasH.Development of cutaneous wound in diabetic immunocompromised mice and use of dental pulp-derived stem cell product for healing[J].Methods Mol Biol,2021,2193:23-30.DOI: 10.1007/978-1-0716-0845-6_3.
    [39]
    PourhadiM,ZaliH,GhasemiR,et al.Promising role of oral cavity mesenchymal stem cell-derived extracellular vesicles in neurodegenerative diseases[J].Mol Neurobiol,2022,59(10):6125-6140.DOI: 10.1007/s12035-022-02951-y.
    [40]
    GongD,YanC,YuF,et al.Direct oral mucosal epithelial transplantation supplies stem cells and promotes corneal wound healing to treat refractory persistent corneal epithelial defects[J].Exp Eye Res,2022,215:108934.DOI: 10.1016/j.exer.2022.108934.
    [41]
    ShoushrahSH,TransfeldJL,TonkCH,et al.Sinking our teeth in getting dental stem cells to clinics for bone regeneration[J].Int J Mol Sci,2021,22(12):6387.DOI: 10.3390/ijms22126387.
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