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Volume 39 Issue 2
Feb.  2023
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Article Navigation >  CHINESE JOURNAL OF BURNS AND WOUNDS  > 2023  >  39(2): 190-195
Wu Q,Tan XY,Wang YJ,et al.Research advances on the mechanism of Wnt/β-catenin signaling pathway in body surface wound healing[J].Chin J Burns Wounds,2023,39(2):190-195.DOI: 10.3760/cma.j.cn501225-20220816-00348.
Citation: Wu Q,Tan XY,Wang YJ,et al.Research advances on the mechanism of Wnt/β-catenin signaling pathway in body surface wound healing[J].Chin J Burns Wounds,2023,39(2):190-195.DOI: 10.3760/cma.j.cn501225-20220816-00348.
shu

Research advances on the mechanism of Wnt/β-catenin signaling pathway in body surface wound healing

doi: 10.3760/cma.j.cn501225-20220816-00348
  • 1.

    Hainan Medical University, Haikou 570105, China

  • 2.

    Department of Emergency and Trauma Surgery, the First Affiliated Hospital of Hainan Medical University, Haikou 570102, China

Funds:

Regional Science Foundation of National Natural Science Foundation of China 82260373, 81860347

Natural Science Foundation of Hainan Province of China 822QN463, 822MS174

Research Project of Health Industry in Hainan Province of China 21A200062, 21A200231

Youth Development Fund of the First Affiliated Hospital of Hainan Medical University HYYFYPY202005

Innovative Entrepreneurship Training Program for Hainan Medical University College Students X202211810008

More Information
    Abstract
  • Wound healing is a slow and complex biological process, including inflammatory reaction, cell proliferation, cell differentiation, cell migration, angiogenesis, extracellular matrix deposition, tissue remodeling, and so on. Wnt signaling pathway can be divided into classical pathway and non-classical pathway. Wnt classical pathway, also known as Wnt/β-catenin signaling pathway, plays an important role in cell differentiation, cell migration, and maintenance of tissue homeostasis. Many inflammatory factors and growth factors are involved in the upstream regulation of this pathway. The activation of Wnt/β-catenin signaling pathway plays an important role in the occurrence, development, regeneration, repair and related treatment of skin wounds. This article review the relationship between Wnt/β-catenin signaling pathway and wound healing, meanwhile summarizes its effects on important processes of wound healing, such as inflammation, cell proliferation, angiogenesis, hair follicle regeneration, and skin fibrosis, as well as the role of inhibitors of Wnt signaling pathway in wound healing.

     

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