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Volume 39 Issue 2
Feb.  2023
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Article Navigation >  CHINESE JOURNAL OF BURNS AND WOUNDS  > 2023  >  39(2): 106-113
He WF,Yan LF.The regulatory role and related mechanisms of macrophages in wound healing[J].Chin J Burns Wounds,2023,39(2):106-113.DOI: 10.3760/cma.j.cn501225-20230110-00010.
Citation: He WF,Yan LF.The regulatory role and related mechanisms of macrophages in wound healing[J].Chin J Burns Wounds,2023,39(2):106-113.DOI: 10.3760/cma.j.cn501225-20230110-00010.
shu

The regulatory role and related mechanisms of macrophages in wound healing

doi: 10.3760/cma.j.cn501225-20230110-00010

  • State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Burn Research, the First Affiliated Hospital of Army Medical University (the Third Military Medical University), Chongqing Key Laboratory for Disease Proteomics, Chongqing 400038, China

Funds:

General Program of National Natural Science Foundation of China 31872742, 82172232

Military Medical Science and Technology Youth Training Program 20QNPY024

Special Project for Enhancing Science and Technology Innovation Ability of Army Medical University 2019XQY12

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    Abstract
  • Wound healing is a complex process under precise regulation, including multiple stages such as inflammation, anti-inflammatory, and regeneration. Macrophages play an important regulatory role in the differentiated process of wound healing due to their obvious plasticity. If macrophages fail to express specific functions in a timely manner, it will affect the healing function of tissues and lead to pathological tissue healing. Therefore, it is of great significance to understand the different functions of different types of macrophages and to regulate them specifically in different stages of wound healing to promote the healing and regeneration of wound tissue. In this paper, we illustrate the different functions of macrophages in the wound and their basic mechanisms, according to the basic process of wound healing, and emphasize the strategies of macrophage regulation that may be applied to clinical treatment in the future.

     

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