Volume 39 Issue 2
Feb.  2023
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Wang DL.Some thoughts on the research of mesenchymal stem cell exosomes and wound microenvironment[J].Chin J Burns Wounds,2023,39(2):101-105.DOI: 10.3760/cma.j.cn501225-20230112-00014.
Citation: Wang DL.Some thoughts on the research of mesenchymal stem cell exosomes and wound microenvironment[J].Chin J Burns Wounds,2023,39(2):101-105.DOI: 10.3760/cma.j.cn501225-20230112-00014.

Some thoughts on the research of mesenchymal stem cell exosomes and wound microenvironment

doi: 10.3760/cma.j.cn501225-20230112-00014
Funds:

General Program of National Natural Science Foundation of China 81871570, 82072195

Science and Technology Project of Guizhou Province 2020-4Y148

Collaborative Innovation Center of Chinese Ministry of Education and Guizhou Province 2020-39

More Information
  • Since researchers have found that the conditioned medium and exosomes of mesenchymal stem cells (MSCs) had the biological effects equivalent to those of MSCs, MSC exosomes (MSC-Exos), the representative product of MSCs' paracrine effect, have become the research focus of the "cell-free" therapy of MSCs. However, most researchers currently use conventional culture condition to culture MSCs and then isolate exosomes for the treatment of wound or other diseases. Theoretically, the paracrine effect of MSCs is directly associated with the pathological condition of the wound (disease) microenvironment or in vitro culture condition, and their paracrine components and biological effects may be altered with the changes of the wound (disease) microenvironment or in vitro culture condition. Thus, the feasibility of using traditional culture condition to culture MSCs for exosome extraction for the treatment of different diseases without considering the actual situation of the disease to be treated needs further discussion. Therefore, the author suggests that the research of MSC-Exos should consider the microenvironment of the wound (disease) to be treated. as much as possible, otherwise the extracted MSC-Exos may not be "accurate" or may not really achieve the treatment effect of MSCs. In this article, we summarized some thoughts of the author and problems related to the researches about MSC-Exos and wound microenvironment, and hoped to discuss with researchers.

     

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