Volume 40 Issue 9
Sep.  2024
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Zhang W,Shao JM,Yang M,et al.Research advance on the effects of surface interface topographies and physicochemical properties of biomaterial on macrophages and their application in wound healing[J].Chin J Burns Wounds,2024,40(9):891-896.DOI: 10.3760/cma.j.cn501225-20231110-00190.
Citation: Zhang W,Shao JM,Yang M,et al.Research advance on the effects of surface interface topographies and physicochemical properties of biomaterial on macrophages and their application in wound healing[J].Chin J Burns Wounds,2024,40(9):891-896.DOI: 10.3760/cma.j.cn501225-20231110-00190.

Research advance on the effects of surface interface topographies and physicochemical properties of biomaterial on macrophages and their application in wound healing

doi: 10.3760/cma.j.cn501225-20231110-00190
Funds:

National Key Research and Development Program of China 2022YFC2403100

General Program of National Natural Science Foundation of China 82172198

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  • The human immune system plays a key role in maintaining tissue homeostasis and disease progression. The development of biomaterials that can regulate the innate immune system and adapt to the immune system has great application prospects in the field of tissue engineering. This paper discusses how to design the surface interface topographies or the physicochemical properties of biomaterials, to regulate the fate of macrophages, such as activation, polarization, adhesion, migration, proliferation, and secretion. At the same time, the application of these biomaterials with immunoregulation function in the field of wound healing is discussed. In addition, this paper also put forward the limitations of biomaterials in immunoregulation applications and prospected the future development directions.

     

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