Mechanisms and intervention strategies of angiogenesis disorders in diabetic foot ulcers

Tao Ke; Cao Tao; Hao Tong

doi:10.3760/cma.j.cn501225-20241204-00474

Volume 41 Issue 2

Feb. 2025

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Article Navigation > CHINESE JOURNAL OF BURNS AND WOUNDS > 2025 > 41(2): 120-126

Tao K,Cao T,Hao T.Mechanisms and intervention strategies of angiogenesis disorders in diabetic foot ulcers[J].Chin J Burns Wounds,2025,41(2):120-126.DOI: 10.3760/cma.j.cn501225-20241204-00474.

Citation:

Tao K,Cao T,Hao T.Mechanisms and intervention strategies of angiogenesis disorders in diabetic foot ulcers[J].Chin J Burns Wounds,2025,41(2):120-126.DOI: 10.3760/cma.j.cn501225-20241204-00474.

Citation:

Tao K,Cao T,Hao T.Mechanisms and intervention strategies of angiogenesis disorders in diabetic foot ulcers[J].Chin J Burns Wounds,2025,41(2):120-126.DOI: 10.3760/cma.j.cn501225-20241204-00474.

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Mechanisms and intervention strategies of angiogenesis disorders in diabetic foot ulcers

doi: 10.3760/cma.j.cn501225-20241204-00474

Tao Ke^{1
,
,},
Cao Tao²,
Hao Tong³

1.
Department of Wound Repair, Center for Wound Repair and Regenerative Medicine, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325015, China
2.
Department of Cell Biology, National Center for Translational Science of Molecular Medicine, Air Force Medical University, Xi'an 710032, China
3.
Department of Burns and Cutaneous Surgery, Burn Center of PLA, the First Affiliated Hospital of Air Force Medical University, Xi'an 710032, China

Funds:

General Program of National Natural Science Foundation of China 82272269

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Corresponding author: Tao Ke, Email: tao-ke2001@163.com
Received Date: 2024-12-04

Abstract

Abstract

Nerve and vascular damage are important factors affecting the occurrence and development of diabetic foot ulcer (DFU). Lower extremity vascular injury combined with microangiogenesis disorder caused by various factors including hyperglycemia, neurotrophic impairment, ischemia, hypoxia, and infection is an important reason for delayed healing of DFU wound. Angiogenesis is a pathophysiological process in which endothelial cells, endothelial progenitor cells, and stem cells rebuild microvascular network under the regulation of various cytokines and microenvironment, which is a key step in the process of DFU wound healing. The mechanisms of DFU wound angiogenesis disorders are complex and diverse. This article summarizes the new progress of DFU microvascular injury mechanism and intervention strategies from three aspects including angiogenesis microenvironment, neuronutrition, and cell function to provide new ideas for the treatment of DFU.
- Diabetic foot,
- Neovascularization, pathologic,
- Wound healing,
- Cellular microenvironment,
- Peripheral nerves

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References(59)

References

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