Keloid is a hyperplastic pathological scar of body caused by infection, trauma, and surgery or formed spontaneously for unknown reasons. It is an excessive tissue response of body to dermal injury. The paper introduces the research advances on inflammatory responses involved in keloid development and keloid treatment by inhibiting inflammatory responses from the aspects of inflammation inducing factors, inflammatory cells, inflammatory mediators, inflammatory effectors, and influencing factors of inflammatory responses. The research results suggest that inflammatory responses are not only essential process to normal wound healing, but also key factors on keloid formation and development.