慢性创面细菌生物膜形成机制及其诊断的研究进展

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Research advances on the formation mechanism and diagnosis of bacteria biofilms in chronic wounds

1. Burn and Plastic Surgery Center, the 940th Hospital of the Joint Logistic Support Force of PLA, Lanzhou 730050, China;
2. Department of Burns and Plastic Surgery&Wound Repair Surgery, Lanzhou University Second Hospital, Lanzhou 730030, China

摘要:
细菌生物膜感染是造成创面延迟愈合的主要因素之一，因此细菌生物膜的早期诊断对慢性创面的成功治愈非常关键。尽管已研发出很多技术诊断感染性创面的游离致病菌，但目前还没有能够快速、准确地识别创面细菌生物膜的技术。本文简要综述了细菌生物膜的形成机制，并重点介绍了几种有潜力的细菌生物膜诊断技术，将来有望成为对创面细菌生物膜进行快速诊断与监测的手段。
- 细菌 /
- 生物膜 /
- 诊断 /
- 慢性创面
Abstract:
Bacterial biofilms infection is one of the major factors causing delayed wound healing. Therefore, early diagnosis of bacterial biofilms is critical for successful cure of chronic wounds. Although many techniques have been developed to diagnose the free pathogens in infectious wounds, there is no technique which can quickly and accurately identify bacterial biofilms in wounds. In this paper, the mechanism of bacterial biofilm formation is briefly reviewed, and several potential diagnostic techniques for bacterial biofilms are introduced, which are expected to be a means of rapid diagnosis and monitoring of bacterial biofilms in wounds.
- Bacteria /
- Biofilms /
- Diagnosis /
- Chronic wounds