Wound repair is one of the common clinical problems faced by burn, plastic, and reconstructive surgeons. Current wound repair strategies applied in clinical settings can only achieve pathological repair instead of physiological regeneration. To 'perfectly' repair the defective tissue is the long-time goal of researchers working in this field for a long time. This review introduces the research updates of skin tissue regeneration in wound repair, focusing on the new concept of tissue regeneration technique with stem cells as the core and the construction of scaffold materials for tissue-engineered skin. In summary, making cells proliferate and differentiate into functional skin organ according to the needs of wound healing, regulating the precise location of different cells in the process of wound healing, and reconstructing the normal structure of skin remain the problems needing future explorations.