-
摘要: 烧伤创面愈合后常表现出一定程度的色素沉着障碍，不仅引起患者的美观和心理问题，影响其正常社交活动，还增加了患处皮肤癌和光老化的风险。正常皮肤色素沉着机制已被广泛研究，但烧伤后皮肤色素沉着障碍的机制有待进一步探索。因此本文在阐述正常皮肤色素沉着机制的基础上对烧伤后创面皮肤色素沉着障碍的最新研究成果进行综述。Abstract: Burn wound healing often shows a certain degree of pigmentation disorder. It may not only cause cosmetic and psychological issues affecting patient's normal social activities, but also increase risk of skin cancer or photoaging. Although normal skin pigmentation is fairly well studied, the mechanism that leads to dyspigmentation after burn injury needs to be further explored. Based on summarizing the mechanism of normal skin pigmentation, this paper reviews the latest research progress in postburn dyspigmentation in recent years.
-
参考文献
(43) [1] LinJY,FisherDE.Melanocyte biology and skin pigmentation[J].Nature,2007,445(7130):843-850.DOI: 10.1038/nature05660. [2] SpronkI,PolinderS,HaagsmaJA,et al.Patient-reported scar quality of adults after burn injuries: a five-year multicenter follow-up study[J].Wound Repair Regen,2019,27(4):406-414.DOI: 10.1111/wrr.12709. [3] DaiNT,ChangHI,WangYW,et al.Restoration of skin pigmentation after deep partial or full-thickness burn injury[J].Adv Drug Deliv Rev,2018,123:155-164.DOI: 10.1016/j.addr.2017.10.010. [4] ShainAH,BastianBC.From melanocytes to melanomas[J].Nat Rev Cancer,2016,16(6):345-358.DOI: 10.1038/nrc.2016.37. [5] AbbasK,QadirMI,AnwarS.The role of melanin in skin cancer[J].Crit Rev Eukaryot Gene Expr,2019,29(1):17-24.DOI: 10.1615/CritRevEukaryotGeneExpr.2018024980. [6] Del BinoS,DuvalC,BernerdF.Clinical and biological characterization of skin pigmentation diversity and its consequences on UV impact[J].Int J Mol Sci,2018,19(9):2668.DOI: 10.3390/ijms19092668. [7] d'IschiaM,WakamatsuK,et al.Melanins and melanogenesis: from pigment cells to human health and technological applications[J].Pigment Cell Melanoma Res,2015,28(5):520-544.DOI: 10.1111/pcmr.12393. [8] ItoS,WakamatsuK.Chemistry of mixed melanogenesis—pivotal roles of dopaquinone[J].Photochem Photobiol,2008,84(3):582-592.DOI: 10.1111/j.1751-1097.2007.00238.x. [9] D'MelloSA,FinlayGJ,et al.Signaling pathways in melanogenesis[J].Int J Mol Sci,2016, 17(7):1144.DOI: 10.3390/ijms17071144. [10] PavanWJ,SturmRA.The genetics of human skin and hair pigmentation[J].Annu Rev Genomics Hum Genet,2019,20:41-72.DOI: 10.1146/annurev-genom-083118-015230. [11] SchallreuterKU,KothariS,ChavanB,et al.Regulation of melanogenesis—controversies and new concepts[J].Exp Dermatol,2008,17(5):395-404.DOI: 10.1111/j.1600-0625.2007.00675.x. [12] HidaT,WakamatsuK,SviderskayaEV,et al.Agouti protein, mahogunin, and attractin in pheomelanogenesis and melanoblast-like alteration of melanocytes: a cAMP-independent pathway[J].Pigment Cell Melanoma Res,2009,22(5):623-634.DOI: 10.1111/j.1755-148X.2009.00582.x. [13] Wolf HorrellEM,BoulangerMC, D'OrazioJA.Melanocortin 1 receptor: structure, function, and regulation[J].Front Genet,2016,7:95.DOI: 10.3389/fgene.2016.00095. [14] SebergHE,Van OtterlooE,CornellRA.Beyond MITF: multiple transcription factors directly regulate the cellular phenotype in melanocytes and melanoma[J].Pigment Cell Melanoma Res,2017,30(5):454-466.DOI: 10.1111/pcmr.12611. [15] KordaßT,WeberCE,OswaldM,et al.SOX5 is involved in balanced MITF regulation in human melanoma cells[J].BMC Med Genomics,2016,9:10.DOI:1 0.1186/s12920-016-0170-0. [16] GuoH,XingY,LiuY,et al.Wnt/β-catenin signaling pathway activates melanocyte stem cells in vitro and in vivo[J].J Dermatol Sci,2016,83(1):45-51.DOI: 10.1016/j.jdermsci.2016.04.005. [17] LeeAY.Recent progress in melasma pathogenesis[J].Pigment Cell Melanoma Res,2015,28(6):648-660.DOI: 10.1111/pcmr.12404. [18] KumariS,Tien Guan ThngS,Kumar VermaN,et al.Melanogenesis inhibitors[J].Acta Derm Venereol,2018,98(10):924-931.DOI: 10.2340/00015555-3002. [19] YuanXH,JinZH.Paracrine regulation of melanogenesis[J].Br J Dermatol,2018,178(3):632-639.DOI: 10.1111/bjd.15651. [20] KinslechnerK,SchützB,PistekM,et al.Loss of SR-BI down- regulates MITF and suppresses extracellular vesicle release in human melanoma[J].Int J Mol Sci,2019,20(5):1063.DOI: 10.3390/ijms20051063. [21] DunnKJ,BradyM,Ochsenbauer-JamborC,et al.WNT1 and WNT3a promote expansion of melanocytes through distinct modes of action[J].Pigment Cell Res,2005,18(3):167-180.DOI: 10.1111/j.1600-0749.2005.00226.x. [22] NguyenNT,FisherDE.MITF and UV responses in skin: from pigmentation to addiction[J].Pigment Cell Melanoma Res,2019,32(2):224-236.DOI: 10.1111/pcmr.12726. [23] SchallreuterKU,KothariS,HasseS,et al.In situ and in vitro evidence for DCoH/HNF-1 alpha transcription of tyrosinase in human skin melanocytes[J].Biochem Biophys Res Commun,2003,301(2):610-616.DOI: 10.1016/s0006-291x(02)03076-0. [24] LiPH,LiuLH,ChangCC,et al.Silencing stem cell factor gene in fibroblasts to regulate paracrine factor productions and enhance c-Kit expression in melanocytes on melanogenesis[J].Int J Mol Sci,2018,19(5):1475.DOI: 10.3390/ijms19051475. [25] GarmynM,YoungAR,MillerSA.Mechanisms of and variables affecting UVR photoadaptation in human skin[J].Photochem Photobiol Sci,2018,17(12):1932-1940.DOI: 10.1039/c7pp00430c. [26] CichorekM,WachulskaM,StasiewiczA,et al.Skin melanocytes: biology and development[J].Postepy Dermatol Alergol,2013,30(1):30-41.DOI: 10.5114/pdia.2013.33376. [27] TravisTE,GhassemiP,Ramella-RomanJC,et al.A multimodal assessment of melanin and melanocyte activity in abnormally pigmented hypertrophic scar[J].J Burn Care Res,2015,36(1):77-86.DOI: 10.1097/BCR.0000000000000154. [28] ChouWC,TakeoM,RabbaniP,et al.Direct migration of follicular melanocyte stem cells to the epidermis after wounding or UVB irradiation is dependent on Mc1r signaling[J].Nat Med,2013,19(7):924-929.DOI: 10.1038/nm.3194. [29] 樊蕊蕊,刘菲琳,郝德顺,等.毛囊源性黑色素细胞的生物学特性及其体外培养技术研究进展[J/CD].中华细胞与干细胞杂志:电子版,2017,7(2):117-123.DOI: 10.3877/cma.j.issn.2095-1221.2017.02.010. [30] SharpeJR,BoothS,JubinK,et al.Progression of wound pH during the course of healing in burns[J].J Burn Care Res,2013,34(3):e201-e208.DOI: 10.1097/BCR.0b013e31825d5569. [31] SaekiH,OikawaA.Stimulation by ionophores of tyrosinase activity of mouse melanoma cells in culture[J].J Invest Dermatol,1985,85(5):423-425.DOI: 10.1111/1523-1747.ep12277091. [32] JothishankarB,SteinSL.Impact of skin color and ethnicity[J].Clin Dermatol,2019,37(5):418-429.DOI: 10.1016/j.clindermatol.2019.07.009. [33] RogasevskaiaTP,SzerencseiRT,JalloulAH,et al.Cellular localization of the K+-dependent Na+-Ca2+ exchanger NCKX5 and the role of the cytoplasmic loop in its distribution in pigmented cells[J].Pigment Cell Melanoma Res,2019,32(1):55-67.DOI: 10.1111/pcmr.12723. [34] AmbrosioAL,BoyleJA,AradiAE,et al.TPC2 controls pigmentation by regulating melanosome pH and size[J].Proc Natl Acad Sci U S A,2016,113(20):5622-5627.DOI: 10.1073/pnas.1600108113. [35] JeschkeMG,van BaarME,ChoudhryMA,et al.Burn injury[J].Nat Rev Dis Primers,2020,6(1):11.DOI: 10.1038/s41572-020-0145-5. [36] HurJ,YangHT,ChunW,et al.Inflammatory cytokines and their prognostic ability in cases of major burn injury[J].Ann Lab Med,2015,35(1):105-110.DOI: 10.3343/alm.2015.35.1.105. [37] SchwachaMG,ThobeBM,DanielT,et al.Impact of thermal injury on wound infiltration and the dermal inflammatory response[J].J Surg Res,2010,158(1):112-120.DOI: 10.1016/j.jss.2008.07.034. [38] SchwachaMG,NickelE,DanielT.Burn injury-induced alterations in wound inflammation and healing are associated with suppressed hypoxia inducible factor-1alpha expression[J].Mol Med,2008,14(9/10):628-633.DOI: 10.2119/2008-00069.Schwacha. [39] CostinGE,HearingVJ.Human skin pigmentation: melanocytes modulate skin color in response to stress[J].FASEB J,2007,21(4):976-994.DOI: 10.1096/fj.06-6649rev. [40] PillaiyarT,ManickamM,JungSH.Recent development of signaling pathways inhibitors of melanogenesis[J].Cell Signal,2017,40:99-115.DOI: 10.1016/j.cellsig.2017.09.004. [41] AdiniI,AdiniA,BazinetL,et al.Melanocyte pigmentation inversely correlates with MCP-1 production and angiogenesis-inducing potential[J].FASEB J,2015,29(2):662-670.DOI: 10.1096/fj.14-255398. [42] CarneyBC,ChenJH,LukerJN,et al.Pigmentation diathesis of hypertrophic scar: an examination of known signaling pathways to elucidate the molecular pathophysiology of injury-related dyschromia[J].J Burn Care Res,2019,40(1):58-71.DOI: 10.1093/jbcr/iry045. [43] AlkhalilA,CarneyBC,TravisTE,et al.Dyspigmented hypertrophic scars:beyond skin color[J].Pigment Cell Melanoma Res,2019,32(5):643-656.DOI: 10.1111/pcmr.12780. -
2022年1期 烧伤缺血缺氧性损害与休克的防治 组稿专家：申传安 2022年2期 烧伤后炎症与免疫 组稿专家：孙炳伟、贺伟峰 2022年3期 烧伤感染、脓毒症 组稿专家：姚咏明、袁志强 2022年4期 扩张术与瘢痕修复 组稿专家：马显杰 2022年5期 烧伤后脏器功能损害 组稿专家：郇京宁 2022年6期 特殊原因创面（冻伤、自身免疫病创面等） 组稿专家：于家傲 2022年7期 生长因子调控创面修复 组稿专家：肖健 2022年8期 烧伤营养 组稿专家：韩春茂 2022年9期 瘢痕的光电治疗 组稿专家：章一新 2022年10期 生物材料在创面修复中的应用 组稿专家：罗高兴 2022年11期 创面修复中的细胞与干细胞治疗 组稿专家：史春梦 2022年12期 烧伤康复 组稿专家：谢卫国 
下载: 导出CSV
-
表(1)
计量
- 文章访问数: 313
- HTML全文浏览量: 64
- PDF下载量: 51
- 被引次数: 0
