血小板浓缩制品在创面修复中的应用研究进展

李羽霖; 陈诺; 谢卫国

doi:10.3760/cma.j.cn501120-20200730-00363

血小板浓缩制品在创面修复中的应用研究进展

doi: 10.3760/cma.j.cn501120-20200730-00363

武汉大学同仁医院暨武汉市第三医院烧伤研究所　　430060

基金项目:

国家自然科学基金面上项目 81772097

重大疾病防治科技行动计划 2018-ZX-01S-001

详细信息

通讯作者:
谢卫国，Email：wgxie@hotmail.com

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- 被引次数: 0
出版历程
- 收稿日期: 2020-07-30

Research advances on the application of platelet concentrate products in wound repair

Institute of Burns, Tongren Hospital of Wuhan University & Wuhan Third Hospital, Wuhan 430060, China

Funds:

General Program of National Natural Science Foundation of China 81772097

Action Plan for Science and Technology in Major Disease Prevention and Control 2018-ZX-01S-001

More Information

Corresponding author: Xie Weiguo, Email: wgxie@hotmail.com

摘要

摘要: 创面的修复过程需要多种生长因子参与调节，但是目前临床上仍然缺乏强效、长效、价格适中的生长因子制剂，而血小板浓缩制品为临床上创面的治疗提供了一种经济、方便、有效的选择。从第1代血小板浓缩制品富血小板血浆开始，研究人员致力于优化血小板浓缩制品的性能，让其具有更强的稳定性、更丰富的生物活性因子以及更优秀的临床表现，富血小板纤维蛋白和浓缩生长因子应运而生。血小板浓缩制品均具有促进创面愈合、提升创面愈合质量的效果。本文旨在对血小板浓缩制品的历史和分类进行综述，对其性质和临床应用进行比较，对其作用机制进行阐述，同时对相关研究中存在的问题和该领域未来发展进行分析和展望。
- 伤口愈合 /
- 富血小板血浆 /
- 生物相容性材料 /
- 富血小板纤维蛋白 /
- 浓缩生长因子
Abstract: Multiple growth factors are required to regulate the wound repair process. Currently, there is still a lack of potent, durable, and inexpensive growth factor product in clinical practice. Meanwhile, platelet concentrate products provide an economical, convenient, and effective choice for the treatment of wounds in clinical practice. Starting from the first generation of platelet concentrate products, platelet-rich plasma, researchers have focused on optimizing the performance of platelet concentrate products for higher stability, more abundant bioactive factors, and more optimal clinical performance. Platelet-rich fibrin and concentrated growth factor emerged since then. Platelet concentrate products have the effect of promoting the speed of wound healing and enhancing the quality. This article aims to summarize the history and classification of platelet concentrate products, compare their properties and clinical applications, elaborate their mechanism of action, and analyze the problems existing in relevant researches while prospecting the future development of this field.
- Wound healing /
- Platelet-rich plasma /
- Biocompatible materials /
- Platelet-rich fibrin /
- Concentrated growth factor
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参考文献(53)

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