Research advances on signaling pathways affecting sweat gland development and their involvement in the reconstitution of sweat adenoid cells in vitro
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摘要: 大面积深度烧伤患者因汗腺毁损导致体温调节功能基本丧失，生活质量受到严重影响。目前对于修复汗腺功能的研究较多，然而人体汗腺发育的机制尚未完全阐明。越来越多的研究表明Wnt/β连环蛋白、外胚叶发育不全/外胚叶发育不全受体/核因子κB、音猬因子、叉头框转录因子等信号通路彼此级联共同影响汗腺发育，并且已有研究报道可以利用级联信号通路实现汗腺样细胞的体外重建。现就影响汗腺发育的信号通路及其参与汗腺样细胞的体外重建情况作一综述。Abstract: The damage of sweat glands in patients with extensive deep burns results in the loss of thermoregulation, which seriously affects the quality of life of patients. At present, there are many researches on the repair of sweat gland function, but the mechanism of human sweat gland development has not been fully clarified. More and more studies have shown that the cascaded pathways of Wnt/β-catenin, ecto- dysplasin A/ectodysplasin A receptor/nuclear factor-κB, sonic hedgehog, and forkhead box transcription factor jointly affect the development of sweat glands, and it has been reported that the cascaded signaling pathways can be used to achieve the reconstruction of sweat adenoid cells in vitro. This article reviews the signaling pathways that affect the development of sweat glands and their involvement in the reconstruction of sweat adenoid cells in vitro.
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Key words:
- Burns /
- Sweat glands /
- Signaling pathways /
- Reconstitution in vitro
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所有作者均声明不存在利益冲突广告目次深圳市源兴医药股份有限公司 ………………………………………………………………………………………… 插页1上海铠唏尔医疗器械贸易有限公司 …………………………………………………………………………………… 插页2南海朗肽制药有限公司 ………………………………………………………………………………………… 对中文目次1江西省科星生物工程有限公司 ………………………………………………………………………………… 对中文目次2上海腾瑞制药股份有限公司 …………………………………………………………………………………… 对英文目次1美纳里尼（中国）投资有限公司 ………………………………………………………………………………………… 插页3保赫曼（上海）贸易有限公司 …………………………………………………………………………………………… 插页4浙江医学科技开发有限公司 …………………………………………………………………………………………… 插页5苏州汇涵医用科技发展有限公司 ……………………………………………………………………………………… 插页6苏州爱得科技发展股份有限公司 ……………………………………………………………………………………… 对正文珠海亿胜生物制药有限公司 ……………………………………………………………………………………………… 封三武汉维斯第医用科技股份有限公司 ……………………………………………………………………………………… 封底
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