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影响汗腺发育的信号通路及其参与汗腺样细胞体外重建的研究进展

郎东浩 巴特 曹胜军 李芳 董行 李俊亮 王凌峰

郎东浩, 巴特, 曹胜军, 等. 影响汗腺发育的信号通路及其参与汗腺样细胞体外重建的研究进展[J]. 中华烧伤与创面修复杂志, 2022, 38(2): 195-200. DOI: 10.3760/cma.j.cn501120-20201020-00442.
引用本文: 郎东浩, 巴特, 曹胜军, 等. 影响汗腺发育的信号通路及其参与汗腺样细胞体外重建的研究进展[J]. 中华烧伤与创面修复杂志, 2022, 38(2): 195-200. DOI: 10.3760/cma.j.cn501120-20201020-00442.
Lang DH,Ba T,Cao SJ,et al.Research advances on signaling pathways affecting sweat gland development and their involvement in the reconstitution of sweat adenoid cells in vitro[J].Chin J Burns Wounds,2022,38(2):195-200.DOI: 10.3760/cma.j.cn501120-20201020-00442.
Citation: Lang DH,Ba T,Cao SJ,et al.Research advances on signaling pathways affecting sweat gland development and their involvement in the reconstitution of sweat adenoid cells in vitro[J].Chin J Burns Wounds,2022,38(2):195-200.DOI: 10.3760/cma.j.cn501120-20201020-00442.

影响汗腺发育的信号通路及其参与汗腺样细胞体外重建的研究进展

doi: 10.3760/cma.j.cn501120-20201020-00442
基金项目: 

国家自然科学基金地区科学基金项目 82060348

内蒙古自治区科技计划 2020GG0214

详细信息
    通讯作者:

    王凌峰,Email:wlf7413@vip.sina.com

Research advances on signaling pathways affecting sweat gland development and their involvement in the reconstitution of sweat adenoid cells in vitro

Funds: 

Regional Science Foundation of National Natural Science Foundation of China 82060348

Science and Technology Plan of Inner Mongolia Autonomous Region of China 2020GG0214

More Information
    Corresponding author: Wang Lingfeng, Email: wlf7413@vip.sina.com
  • 摘要: 大面积深度烧伤患者因汗腺毁损导致体温调节功能基本丧失,生活质量受到严重影响。目前对于修复汗腺功能的研究较多,然而人体汗腺发育的机制尚未完全阐明。越来越多的研究表明Wnt/β连环蛋白、外胚叶发育不全/外胚叶发育不全受体/核因子κB、音猬因子、叉头框转录因子等信号通路彼此级联共同影响汗腺发育,并且已有研究报道可以利用级联信号通路实现汗腺样细胞的体外重建。现就影响汗腺发育的信号通路及其参与汗腺样细胞的体外重建情况作一综述。

     

  • 参考文献(31)

    [1] CuiCY, SchlessingerD. Eccrine sweat gland development and sweat secretion[J]. Exp Dermatol, 2015,24(9):644-650. DOI: 10.1111/exd.12773.
    [2] WuCX, LiuZF. Proteomic profiling of sweat exosome suggests its involvement in skin immunity[J].J Invest Dermatol,2018,138(1):89-97.DOI: 10.1016/j.jid.2017.05.040.
    [3] 韩兵汗腺发育相关基因及其联用骨髓间充质干细胞促进汗腺再生修复的研究北京中国人民解放军军医进修学院2007

    韩兵. 汗腺发育相关基因及其联用骨髓间充质干细胞促进汗腺再生修复的研究[D].北京:中国人民解放军军医进修学院,2007.

    [4] CleversH,NusseR.Wnt/β-catenin signaling and disease[J].Cell,2012,149(6):1192-1205.DOI: 10.1016/j.cell.2012.05.012.
    [5] LohKM,van AmerongenR,NusseR.Generating cellular diversity and spatial form: Wnt signaling and the evolution of multicellular animals[J].Dev Cell,2016,38(6):643-655.DOI: 10.1016/j.devcel.2016.08.011.
    [6] Kowalczyk-QuintasC, SchneiderP. Ectodysplasin A (EDA) - EDA receptor signalling and its pharmacological modulation[J]. Cytokine Growth Factor Rev,2014,25(2):195-203. DOI: 10.1016/j.cytogfr.2014.01.004.
    [7] LuC, FuchsE. Sweat gland progenitors in development, homeostasis, and wound repair[J].Cold Spring Harb Perspect Med,2014,4(2):a015222. DOI: 10.1101/cshperspect.a015222.
    [8] KunisadaM, CuiCY, PiaoYL, et al. Requirement for Shh and Fox family genes at different stages in sweat gland development[J].Hum Mol Genet,2009,18(10):1769-1778.DOI: 10.1093/hmg/ddp089.
    [9] CuiCY, YinMZ, SimaJ, et al. Involvement of Wnt, Eda and Shh at defined stages of sweat gland development[J]. Development,2014,141(19):3752-3760.DOI: 10.1242/dev.109231.
    [10] 李倩坤,张翠萍,付小兵.干细胞实现汗腺再生的机制分析[J].感染、炎症、修复,2016,17(3):172-176. DOI: 10.3969/j.issn.1672-8521.2016.03.016.
    [11] XuMG, HorrellJ, SnitowM, et al.WNT10A mutation causes ectodermal dysplasia by impairing progenitor cell proliferation and KLF4-mediated differentiation[J].Nat Commun,2017,8:15397.DOI: 10.1038/ncomms15397.
    [12] YoshidaY, YamasakiS, OiK, et al. IL-1β enhances Wnt signal by inhibiting DKK1[J]. Inflammation, 2018,41(5):1945-1954. DOI: 10.1007/s10753-018-0838-z.
    [13] DuanHY, YanZQ, ChenW, et al. TET1 inhibits EMT of ovarian cancer cells through activating Wnt/β-catenin signaling inhibitors DKK1 and SFRP2[J]. Gynecol Oncol,2017,147(2):408-417. DOI: 10.1016/j.ygyno.2017.08.010.
    [14] SimaJ, PiaoYL, ChenYH, et al. Molecular dynamics of Dkk4 modulates Wnt action and regulates meibomian gland development[J]. Development,2016,143(24):4723-4735. DOI: 10.1242/dev.143909.
    [15] CheeMK, JoSK, SohnKC, et al. Effects of Brn2 overexpression on eccrine sweat gland development in the mouse paw[J]. Biochem Biophys Res Commun, 2017,490(3):901-905. DOI: 10.1016/j.bbrc.2017.06.138.
    [16] SimaJ, YanZJ, ChenYH, et al.Eda-activated RelB recruits an SWI/SNF (BAF) chromatin-remodeling complex and initiates gene transcription in skin appendage formation[J].Proc Natl Acad Sci U S A,2018,115(32):8173-8178.DOI: 10.1073/pnas.1800930115.
    [17] KumarA, EbyMT, SinhaS, et al. The ectodermal dysplasia receptor activates the nuclear factor-kappaB, JNK, and cell death pathways and binds to ectodysplasin A[J]. J Biol Chem, 2001,276(4):2668-2677. DOI: 10.1074/jbc.M008356200.
    [18] LiuGN, WangX, QinM, et al. A novel missense mutation p.S305R of EDA gene causes XLHED in a Chinese family[J].Arch Oral Biol,2019,107:104507.DOI: 10.1016/j.archoralbio.2019.104507.
    [19] WohlfartS, SchneiderH. Variants of the ectodysplasin A1 receptor gene underlying homozygous cases of autosomal recessive hypohidrotic ectodermal dysplasia[J]. Clin Genet,2019,95(3):427-432. DOI: 10.1111/cge.13503.
    [20] SrivastavaAK, DurmowiczMC, HartungAJ, et al.Ectodysplasin-A1 is sufficient to rescue both hair growth and sweat glands in Tabby mice[J].Hum Mol Genet,2001,10(26):2973-2981.DOI: 10.1093/hmg/10.26.2973.
    [21] GaideO, SchneiderP. Permanent correction of an inherited ectodermal dysplasia with recombinant EDA[J].Nat Med,2003,9(5):614-618.DOI: 10.1038/nm861.
    [22] CuiCY, ChildressV, PiaoYL, et al. Forkhead transcription factor FoxA1 regulates sweat secretion through Bestrophin 2 anion channel and Na-K-Cl cotransporter 1[J].Proc Natl Acad Sci U S A,2012,109(4):1199-1203.DOI: 10.1073/pnas.1117213109.
    [23] LiSM, ZhouJ, ZhangLY, et al. Ectodysplasin A regulates epithelial barrier function through sonic hedgehog signalling pathway[J]. J Cell Mol Med,2018,22(1): 230-240. DOI: 10.1111/jcmm.13311.
    [24] ZhangYH, TomannP, AndlT, et al.Reciprocal requirements for EDA/EDAR/NF-kappaB and Wnt/beta-catenin signaling pathways in hair follicle induction[J].Dev Cell,2009,17(1):49-61.DOI: 10.1016/j.devcel.2009.05.011.
    [25] HuangZJ, ZhenYF, YinW, et al. Shh promotes sweat gland cell maturation in three-dimensional culture[J]. Cell Tissue Bank,2016,17(2):317-325. DOI: 10.1007/s10561-016-9548-7.
    [26] YaoB, XieJF, LiuNB, et al. Direct reprogramming of epidermal cells toward sweat gland-like cells by defined factors[J]. Cell Death Dis,2019,10(4):272. DOI: 10.1038/s41419-019-1503-7.
    [27] 李海红,付小兵,欧阳云淑,等.人骨髓间充质干细胞表型转化为汗腺细胞的体外研究[J].中华创伤杂志,2006,22(2):81-86.DOI: 10.3760/j:issn:1001-8050.2006.02.001.
    [28] ShengZY, FuXB, CaiS, et al. Regeneration of functional sweat gland-like structures by transplanted differentiated bone marrow mesenchymal stem cells[J].Wound Repair Regen,2009,17(3):427-435.DOI: 10.1111/j.1524-475X.2009.00474.x.
    [29] 付小兵,杨思明.中国的再生医学与烧伤救治[J].中华烧伤杂志,2013,29(2):102-104.DOI: 10.3760/cma.j.issn.1009-2587.2013.02.002.
    [30] ZhaoZL, XuMY, WuM, et al. Direct reprogramming of human fibroblasts into sweat gland-like cells[J].Cell Cycle,2015,14(21):3498-3505.DOI: 10.1080/15384101.2015.1093707.
    [31] SunSJ, XiaoJ, HuoJH, et al. Targeting ectodysplasin promotor by CRISPR/dCas9-effector effectively induces the reprogramming of human bone marrow-derived mesenchymal stem cells into sweat gland-like cells[J]. Stem Cell Res Ther,2018,9(1):8.DOI: 10.1186/s13287-017-0758-0.
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  • 收稿日期:  2020-10-20

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