Influencing factors and their predictive value of skin graft survival after Meek grafting in severe burn patients
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摘要:
目的 探讨严重烧伤患者Meek植皮术后皮片存活情况的影响因素及其预测价值。 方法 2013年1月—2019年12月,陆军军医大学(第三军医大学)第一附属医院收治115例符合入选标准的严重烧伤且行Meek植皮治疗的患者(男95例、女20例,年龄1~74岁),对其进行回顾性病例对照研究。将患者分为皮片存活率≥70%的皮片存活良好组(68例)和皮片存活率<70%的皮片存活不良组(47例)。统计2组患者入院后行第1次Meek植皮术时的性别,年龄,体重指数,Ⅲ度烧伤面积,烧伤指数,合并吸入性损伤情况,伤后手术时间,术前半胱氨酸蛋白酶抑制剂C水平、白蛋白水平、中性粒细胞、血红蛋白水平、血小板计数,术后第1、3、5天血小板计数。对上述指标行组间独立样本
t 检验、Mann-Whitney
U 检验、
χ 2检验。对2组患者性别、年龄、体重指数、Ⅲ度烧伤面积、烧伤指数、合并吸入性损伤情况、伤后手术时间行1∶1倾向评分匹配(PSM)消除基线资料差异后,对2组剩余患者再次行上述指标统计与检验。选择行1∶1 PSM后2组比较中差异有统计学意义的指标进行多因素logistic回归分析,筛选影响严重烧伤患者Meek植皮术后皮片存活的独立危险因素。绘制独立危险因素对行1∶1 PSM后严重烧伤患者Meek植皮术后皮片存活不良预测的受试者操作特征(ROC)曲线,计算曲线下面积及最佳阈值与最佳阈值下的敏感度、特异度。将行1∶1 PSM后的患者分为独立危险因素>最佳阈值组和独立危险因素≤最佳阈值组,采用
χ 2检验对比Meek植皮术后皮片存活不良发生率,计算Meek植皮术后皮片存活不良的相对危险度。 结果 行1∶1 PSM前,2组患者性别、年龄、体重指数、合并吸入性损伤情况、伤后手术时间、术前半胱氨酸蛋白酶抑制剂C水平、术前白蛋白水平、术前中性粒细胞、术前血红蛋白水平比较,差异均无统计学意义(
P >0.05);皮片存活不良组患者Ⅲ度烧伤面积、烧伤指数均明显高于皮片存活良好组(
Z =-2.672、-2.882,
P <0.01),术前及术后第1、3、5天血小板计数均明显低于皮片存活良好组(
Z =-3.411、-3.050、-2.748、-2.686,
P <0.01)。行1∶1 PSM后,每组各剩余46例患者。2组剩余患者性别、年龄、体重指数、Ⅲ度烧伤面积、烧伤指数、合并吸入性损伤情况、伤后手术时间、术前半胱氨酸蛋白酶抑制剂C水平、术前白蛋白水平、术前中性粒细胞、术前血红蛋白水平比较,差异均无统计学意义(
P >0.05);皮片存活不良组患者术前及术后第1、3、5天血小板计数均明显低于皮片存活良好组(
Z =-3.428、-2.940,
t =-2.427、-2.316,
P <0.05或
P <0.01)。多因素logistic回归分析显示,仅术前血小板计数为影响严重烧伤患者Meek植皮术后皮片存活的独立危险因素(比值比=0.994,95%置信区间=0.989~0.998,
P <0.01)。术前血小板计数对92例患者Meek植皮术后皮片存活不良预测的ROC曲线下面积为0.707(95%置信区间=0.603~0.798,
P <0.01);术前血小板计数最佳阈值为98×109/L,最佳阈值下的敏感度和特异度分别为54.3%和78.3%。术前血小板计数≤98×109/L组患者Meek植皮术后皮片存活不良发生率为71.4%(25/35),明显高于术前血小板计数>98×109/L组的36.8%(21/57),
χ 2=10.376,
P <0.01。与术前血小板计数>98×109/L组相比,术前血小板计数≤98×109/L组患者行Meek植皮术后皮片存活不良的相对危险度为2.211(95%置信区间=1.263~3.870)。 结论 术前血小板计数是影响严重烧伤患者Meek植皮术后皮片存活的独立危险因素,且具有较好的预测价值;当患者术前血小板计数≤98×109/L时,应谨慎进行Meek植皮手术。
Abstract:Objective To investigate the influencing factors and their predictive value of skin graft survival after Meek grafting in severe burn patients. Methods A retrospective case-control study was conducted in 115 severe burn patients (95 males, 20 females, aged 1-74 years) who met the inclusion criteria and received Meek grafting in the First Affiliated Hospital of Army Medical University (the Third Military Medical University) from January 2013 to December 2019. The patients were divided into good skin graft survival group with skin graft survival rate≥70% (68 cases) and poor skin graft survival group with skin graft survival rate<70% (47 cases). The statistics of patients in the two groups were recorded during their first Meek grafting after admission including the gender, age, body mass index, full-thickness burn area, burn index, complication of inhalation injury, time from injury to operation, preoperative cystatin C level, preoperative albumin level, preoperative neutrophil, preoperative hemoglobin level, preoperative platelet count, and platelet count on the first, third, and fifth day after operation. The above indicators were statistically analyzed between the two groups with independent sample
t test, Mann-Whitney
U test, and chi-square test. A 1∶1 propensity score matching (PSM) of the gender, age, body mass index, full-thickness burn area, burn index, complication of inhalation injury, time from injury to operation of patients in the two groups were performed to eliminate the differences in baseline data, and then the above indicators of the remaining patients in the two groups were recorded and analyzed again. The indicators with statistically significant differences between the two groups after 1∶1 PSM were selected for multivariate logistic regression analysis to screen the independent risk factors affecting the skin graft survival after Meek grafting in severe burn patients. The receiver operating characteristic (ROC) curve of independent risk factors for predicting poor skin graft survival after Meek grafting in severe burn patients after 1∶1 PSM was drawn, and the area under the curve, the cut-off value, and the sensitivity and specificity under the cut-off value were calculated. The patients after 1∶1 PSM were divided into independent risk factor>the cut-off value group and independent risk factor≤the cut-off value group with the incidence of poor skin graft survival after Meek grafting compared using the chi-square test, and the relative risk of poor skin graft survival after Meek grafting was calculated. Results Before 1∶1 PSM, there were no statistically significant differences in gender, age, body mass index, complication of inhalation injury, time from injury to operation, preoperative cystatin C level, preoperative albumin level, preoperative neutrophil, preoperative hemoglobin level of patients between the two groups (
P >0.05); the full-thickness burn area and burn index of patients in poor skin graft survival group were significantly higher than those in good skin graft survival group (
Z =-2.672, -2.882,
P <0.01); the preoperative platelet count and the platelet count on the first, third, and fifth day after operation of patients in poor skin graft survival group were significantly lower than those in good skin graft survival group (
Z= -3.411, -3.050, -2.748, -2.686
, P <0.01). After 1∶1 PSM, 46 cases were remained in each group. There were no statistically significant differences in gender, age, body mass index, full-thickness burn area, burn index, complication of inhalation injury, time from injury to operation, preoperative cystatin C level, preoperative albumin level, preoperative neutrophil, preoperative hemoglobin level of remaining patients between the two groups (
P >0.05); the preoperative platelet count and the platelet count on the first, third, and fifth day after operation of patients in poor skin graft survival group were significantly lower than those in good skin graft survival group (
Z =-3.428, -2.940,
t =-2.427, -2.316,
P <0.05 or
P <0.01). Multivariate logistic regression analysis showed that the preoperative platelet count was the only independent risk factor affecting the skin graft survival after Meek grafting in severe burn patients (odds ratio=0.994, 95% confidence interval=0.989-0.998,
P <0.01). The area under the ROC curve of preoperative platelet count predicting poor skin graft survival after Meek grafting in 92 patients was 0.707 (95% confidence interval=0.603-0.798,
P <0.01), and the cut-off value of preoperative platelet count was 98×109/L, with sensitivity of 54.3% and specificity of 78.3% under the cut-off value. The incidence of poor skin survival after Meek grafting of patients in preoperative platelet count≤98×109/L group was 71.4% (25/35), which was obviously higher than 36.8% (21/57) in preoperative platelet count>98×109/L group (
χ 2=10.376,
P <0.01). compared="" with="" that="" in="" preoperative="" platelet="" count="">98×109/L group, patients in preoperative platelet count≤98×109/L group had a relative risk of poor skin graft survival after Meek grafting of 2.211 (95% confidence interval=1.263-3.870). Conclusions Preoperative platelet count is an independent risk factor affecting the skin graft survival after Meek grafting in severe burn patients and has a good predictive value. Meek grafting should be performed with caution when the preoperative platelet count of patients is≤98×109/L.
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Key words:
- Burns /
- Platelet count /
- Forecasting /
- Meek grafting
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