Diabetic foot has a high rate of disability and mortality. Negative pressure wound therapy (NPWT) is one of the effective techniques in treating diabetic foot wounds, but the non-standard use of it often leads to infections, bleeding, necrosis and other complications, seriously affecting the outcome. Tissue Repair of Burns and Trauma Committee and Cross-Straits Medicine Exchange Association organized experts of multiple disciplinary specialties including burns, orthopedics, vascular surgery, endocrinology, wound repair, who are engaged in the treatment of diabetic foot to discuss and write the "National expert consensus on the application of negative pressure wound therapy in the treatment of diabetic foot wounds (2021 version)". This consensus is based on evidence-based medicine and combined with the latest clinical research progress, aiming to form a standardized plan for the treatment of diabetic foot wounds with NPWT. It can be used as a reference for clinicians, so as to promote the improvement of clinical diagnosis and treatment of diabetic foot.