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白细胞介素6在增生性瘢痕形成中的作用研究进展

陈祖涵 余斌 叶啟发 王彦峰

陈祖涵, 余斌, 叶啟发, 等. 白细胞介素6在增生性瘢痕形成中的作用研究进展[J]. 中华烧伤与创面修复杂志, 2022, 38(9): 874-877. DOI: 10.3760/cma.j.cn501120-20210331-00111.
引用本文: 陈祖涵, 余斌, 叶啟发, 等. 白细胞介素6在增生性瘢痕形成中的作用研究进展[J]. 中华烧伤与创面修复杂志, 2022, 38(9): 874-877. DOI: 10.3760/cma.j.cn501120-20210331-00111.
Chen ZH,Yu B,Ye QF,et al.Research advances on interleukin-6 in hypertrophic scar formation[J].Chin J Burns Wounds,2022,38(9):874-877.DOI: 10.3760/cma.j.cn501120-20210331-00111.
Citation: Chen ZH,Yu B,Ye QF,et al.Research advances on interleukin-6 in hypertrophic scar formation[J].Chin J Burns Wounds,2022,38(9):874-877.DOI: 10.3760/cma.j.cn501120-20210331-00111.

白细胞介素6在增生性瘢痕形成中的作用研究进展

doi: 10.3760/cma.j.cn501120-20210331-00111
基金项目: 

武汉大学中南医院科技创新培育基金 znpy2019083

详细信息
    通讯作者:

    王彦峰,Email:yanfengwang@whu.edu.cn

Research advances on interleukin-6 in hypertrophic scar formation

Funds: 

Science and Technology Innovation Cultivation Fund of Zhongnan Hospital of Wuhan University znpy2019083

More Information
  • 摘要: 增生性瘢痕是受损皮肤的细胞外基质过度堆积导致的病理性修复结果,不同程度地影响患者的外观和功能。瘢痕形成的程度与创面愈合过程中炎症反应的强弱直接相关,过度或延长的炎症反应会增加增生性瘢痕的发生率。白细胞介素6(IL-6)是一种多效性细胞因子,可参与调控由成纤维细胞、巨噬细胞、角质形成细胞和血管内皮细胞组成的促纤维化网络,与增生性瘢痕的形成密切相关。该文就IL-6及其信号通路在增生性瘢痕形成中的作用进行综述。

     

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  • 1  IL-6在由成纤维细胞、巨噬细胞、角质形成细胞和血管内皮细胞组成的皮肤促纤维化网络中占据中心地位

    注:IL为白细胞介素,TNF-α为肿瘤坏死因子α,TGF-β为转化生长因子β,PDGF为血小板衍生生长因子,MCP-1为单核趋化蛋白1,VEGF为血管内皮生长因子,KGF为角质形成细胞生长因子;↑表示上调或升高

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  • 收稿日期:  2021-03-31

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