外泌汗腺汗液分泌离子通道调控机制研究进展

沈嘉生; 许永安

doi:10.3760/cma.j.cn501120-20210517-00191

外泌汗腺汗液分泌离子通道调控机制研究进展

doi: 10.3760/cma.j.cn501120-20210517-00191

沈嘉生¹,
许永安^2, ,

1.
浙江大学医学院附属第四医院急诊科，义乌　　322014
2.
浙江大学医学院附属第二医院急诊科，杭州　　310003

基金项目:

国家自然科学基金面上项目 81571916, 81372079

国家自然科学基金青年科学基金项目 81201478

详细信息

通讯作者:
许永安，Email：xuyongan2000@163.com

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- 被引次数: 0
出版历程
- 收稿日期: 2021-05-17

Research advances on the regulatory mechanism of sweat secretion ion channels of eccrine sweat glands

Shen Jiasheng¹,
Xu Yong'an^{2
, ,}

1.
Department of Emergency, the Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu 322014, China
2.
Department of Emergency, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China

Funds:

General Program of National Natural Science Foundation of China 81571916, 81372079

Youth Science Foundation Project of National Natural Science Foundation of China 81201478

More Information

Corresponding author: Xu Yong'an, Email: xuyongan2000@163.com

摘要

摘要: 汗腺在人体皮肤中分布广泛，其中外泌汗腺主要起散热排汗作用。汗液分泌由神经系统调控，包括分泌部分泌与导管部重吸收2个过程，涉及钙离子通道、钾离子通道、钠钾氯协同转运蛋白1、Best2蛋白、水通道蛋白5、囊性纤维化跨膜转导调节因子、上皮钠离子通道等多种离子通道和蛋白。该文将对涉及外泌汗腺汗液分泌的神经传导体系、各类离子通道等进行综述，以期为损伤汗腺再生修复及干细胞转化研究提供一定的理论依据。
- 外分泌汗腺 /
- 离子通道 /
- 皮肤 /
- 汗液分泌 /
- 神经调控
Abstract: Sweat glands are widely distributed in human skin, among which eccrine sweat glands play major roles in heat dissipation and sweat secretion. Sweat secretion is mainly regulated by nervous system and includes two processes of secretion of secretory coil and reabsorption of sweat duct, involving various ion channels and proteins such as calcium ion channel, potassium ion channel, sodium-potassium-chloride co-transporter 1, Best2 protein, aquaporin 5, cystic fibrosis transmembrane conductance regulator, and epithelial sodium ion channel. This paper reviews the nerve conduction system and various ion channels involved in sweat secretion of exocrine sweat glands in order to provide a theoretical basis for the study of regeneration, repair, and transformation of stem cells.
- Eccrine glands /
- Ion channels /
- Skin /
- Sweat secretion /
- Neural regulation
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参考文献(33)

[1]	Saint-CriqV, GrayMA. Role of CFTR in epithelial physiology[J]. Cell Mol Life Sci, 2017, 74(1):93-115. DOI: 10.1007/s00018-016-2391-y.
[2]	HuY, ConverseC, LyonsMC, et al. Neural control of sweat secretion: a review[J]. Br J Dermatol, 2018, 178(6):1246-1256. DOI: 10.1111/bjd.15808.
[3]	刘煜凡, 黄沙, 付小兵. 皮肤附属器汗腺发育及功能的机制研究[J]. 生命科学, 2020, 32(3):219-226. DOI: 10.13376/j.cbls/2020030.
[4]	DiaoJ, LiuJ, WangS, et al. Sweat gland organoids contribute to cutaneous wound healing and sweat gland regeneration[J]. Cell Death Dis, 2019, 10(3):238. DOI: 10.1038/s41419-019-1485-5.
[5]	KlakaP, GrüdlS, BanowskiB, et al. A novel organotypic 3D sweat gland model with physiological functionality[J]. PLoS One, 2017, 12(8):e0182752. DOI: 10.1371/journal.pone.0182752.
[6]	SasakiS, WatanabeJ, OhtakiH, et al. Pituitary adenylate cyclase-activating polypeptide promotes eccrine gland sweat secretion[J]. Br J Dermatol, 2017, 176(2):413-422. DOI: 10.1111/bjd.14885.
[7]	StevensLM, LandisSC. Development and properties of the secretory response in rat sweat glands: relationship to the induction of cholinergic function in sweat gland innervation[J]. Dev Biol, 1987, 123(1):179-190. DOI: 10.1016/0012-1606(87)90440-4.
[8]	GrantMP, LandisSC, SiegelRE. The molecular and pharmacological properties of muscarinic cholinergic receptors expressed by rat sweat glands are unaltered by denervation[J]. J Neurosci, 1991, 11(12):3763-3771. DOI: 10.1523/JNEUROSCI.11-12-03763.1991.
[9]	AlzayadyKJ, WangL, ChandrasekharR, et al. Defining the stoichiometry of inositol 1,4,5-trisphosphate binding required to initiate Ca2+ release[J]. Sci Signal, 2016, 9(422):ra35. DOI: 10.1126/scisignal.aad6281.
[10]	KlarJ, HisatsuneC, BaigSM, et al. Abolished InsP3R2 function inhibits sweat secretion in both humans and mice[J]. J Clin Invest, 2014, 124(11):4773-4780. DOI: 10.1172/JCI70720.
[11]	SatoK, SatoF. Role of calcium in cholinergic and adrenergic mechanisms of eccrine sweat secretion[J]. Am J Physiol, 1981, 241(3):C113-120. DOI: 10.1152/ajpcell.1981.241.3.C113.
[12]	Metzler-WilsonK, SammonsDL, OssimMA, et al. Extracellular calcium chelation and attenuation of calcium entry decrease in vivo cholinergic-induced eccrine sweating sensitivity in humans[J]. Exp Physiol, 2014, 99(2):393-402. DOI: 10.1113/expphysiol.2013.076547.
[13]	ConcepcionAR, VaethM, WagnerLE, et al. Store-operated Ca2+ entry regulates Ca2+-activated chloride channels and eccrine sweat gland function[J]. J Clin Invest, 2016, 126(11):4303-4318. DOI: 10.1172/JCI89056.
[14]	DerouicheS, TakayamaY, MurakamiM, et al. TRPV4 heats up ANO1-dependent exocrine gland fluid secretion[J]. FASEB J, 2018, 32(4):1841-1854. DOI: 10.1096/fj.201700954R.
[15]	DelporteC. Aquaporins and gland secretion[J]. Adv Exp Med Biol, 2017, 969:63-79. DOI: 10.1007/978-94-024-1057-0_4.
[16]	SatoF, SatoK. Effect of periglandular ionic composition and transport inhibitors on rhesus monkey eccrine sweat gland function in vitro[J]. J Physiol, 1987, 393:195-212. DOI: 10.1113/jphysiol.1987.sp016819.
[17]	Ertongur-FauthT, HochheimerA, BuescherJM, et al. A novel TMEM16A splice variant lacking the dimerization domain contributes to calcium-activated chloride secretion in human sweat gland epithelial cells[J]. Exp Dermatol, 2014, 23(11):825-831. DOI: 10.1111/exd.12543.
[18]	OwjiAP, ZhaoQ, JiC, et al. Structural and functional characterization of the bestrophin-2 anion channel[J]. Nat Struct Mol Biol, 2020, 27(4):382-391. DOI: 10.1038/s41594-020-0402-z.
[19]	CuiCY, ChildressV, PiaoY, et al. Forkhead transcription factor FoxA1 regulates sweat secretion through Bestrophin 2 anion channel and Na-K-Cl cotransporter 1[J]. Proc Natl Acad Sci U S A, 2012, 109(4):1199-1203. DOI: 10.1073/pnas.1117213109.
[20]	MackGW, SmithBS, RowlandB. TEA-sensitive K+ channels and human eccrine sweat gland output[J]. J Appl Physiol (1985), 2019, 127(4):921-929. DOI: 10.1152/japplphysiol.00308.2019.
[21]	CuiCY, SimaJ, YinM, et al. Identification of potassium and chloride channels in eccrine sweat glands[J]. J Dermatol Sci, 2016, 81(2):129-131. DOI: 10.1016/j.jdermsci.2015.11.001.
[22]	InoueR. New findings on the mechanism of perspiration including aquaporin-5 water channel[J]. Curr Probl Dermatol, 2016, 51:11-21. DOI: 10.1159/000446754.
[23]	NejsumLN, KwonTH, JensenUB, et al. Functional requirement of aquaporin-5 in plasma membranes of sweat glands[J]. Proc Natl Acad Sci U S A, 2002, 99(1):511-516. DOI: 10.1073/pnas.012588099.
[24]	SongY, SonawaneN, VerkmanAS. Localization of aquaporin-5 in sweat glands and functional analysis using knockout mice[J]. J Physiol, 2002, 541(Pt 2):561-568. DOI: 10.1113/jphysiol.2001.020180.
[25]	HanukogluI, BoggulaVR, VaknineH, et al. Expression of epithelial sodium channel (ENaC) and CFTR in the human epidermis and epidermal appendages[J]. Histochem Cell Biol, 2017, 147(6):733-748. DOI: 10.1007/s00418-016-1535-3.
[26]	RauhR, HoernerC, KorbmacherC. δβγ-ENaC is inhibited by CFTR but stimulated by cAMP in Xenopus laevis oocytes[J]. Am J Physiol Lung Cell Mol Physiol, 2017, 312(2):L277-L287. DOI: 10.1152/ajplung.00375.2016.
[27]	HeM, ZhouT, NiuY, et al. The protease corin regulates electrolyte homeostasis in eccrine sweat glands[J]. PLoS Biol, 2021, 19(2):e3001090. DOI: 10.1371/journal.pbio.3001090.
[28]	张静娟, 王茂英, 赵洁, 等. 干细胞在汗腺再生中的应用研究进展[J]. 中华烧伤与创面修复杂志, 2022, 38(3):296-300. DOI: 10.3760/cma.j.cn501120-20210123-00033.
[29]	郎东浩, 巴特, 曹胜军, 等. 影响汗腺发育的信号通路及其参与汗腺样细胞体外重建的研究进展[J]. 中华烧伤与创面修复杂志, 2022, 38(2):195-200. DOI: 10.3760/cma.j.cn501120-20201020-00442.
[30]	SongW, YaoB, ZhuD, et al. 3D-bioprinted microenvironments for sweat gland regeneration[J/OL]. Burns Trauma, 2022, 10:tkab044[2022-06-06]. https://pubmed.ncbi.nlm.nih.gov/35071651/.DOI: 10.1093/burnst/tkab044.
[31]	WangR, WangY, YaoB, et al. Redirecting differentiation of mammary progenitor cells by 3D bioprinted sweat gland microenvironment[J/OL]. Burns Trauma, 2019, 7:29[2021-05-17]. https://pubmed.ncbi.nlm.nih.gov/31559316/.DOI: 10.1186/s41038-019-0167-y.
[32]	ZhangY, Enhejirigala, YaoB, et al. Using bioprinting and spheroid culture to create a skin model with sweat glands and hair follicles[J/OL]. Burns Trauma, 2021, 9:tkab013[2022-06-17]. https://pubmed.ncbi.nlm.nih.gov/34213515/.DOI: 10.1093/burnst/tkab013.
[33]	朱冬振, 王一惠, 王睿, 等. 外源性肿瘤坏死因子α对三维环境下小鼠间充质干细胞向汗腺细胞分化的影响及机制[J]. 中华烧伤杂志, 2020, 36(3):187-194. DOI: 10.3760/cma.j.cn501120-20200105-00005.