外泌汗腺汗液分泌离子通道调控机制研究进展

沈嘉生; 许永安

doi:10.3760/cma.j.cn501120-20210517-00191

外泌汗腺汗液分泌离子通道调控机制研究进展

doi: 10.3760/cma.j.cn501120-20210517-00191

沈嘉生¹,
许永安^2, ,

1.
浙江大学医学院附属第四医院急诊科，义乌　　322014
2.
浙江大学医学院附属第二医院急诊科，杭州　　310003

基金项目:

国家自然科学基金面上项目 81571916, 81372079

国家自然科学基金青年科学基金项目 81201478

详细信息

通讯作者:
许永安，Email：xuyongan2000@163.com

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- 文章访问数: 182
- HTML全文浏览量: 60
- PDF下载量: 27
- 被引次数: 0
出版历程
- 收稿日期: 2021-05-17

Research advances on the regulatory mechanism of sweat secretion ion channels of eccrine sweat glands

Shen Jiasheng¹,
Xu Yong'an^{2
, ,}

1.
Department of Emergency, the Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu 322014, China
2.
Department of Emergency, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China

Funds:

General Program of National Natural Science Foundation of China 81571916, 81372079

Youth Science Foundation Project of National Natural Science Foundation of China 81201478

More Information

Corresponding author: Xu Yong'an, Email: xuyongan2000@163.com

摘要

摘要: 汗腺在人体皮肤中分布广泛，其中外泌汗腺主要起散热排汗作用。汗液分泌由神经系统调控，包括分泌部分泌与导管部重吸收2个过程，涉及钙离子通道、钾离子通道、钠钾氯协同转运蛋白1、Best2蛋白、水通道蛋白5、囊性纤维化跨膜转导调节因子、上皮钠离子通道等多种离子通道和蛋白。该文将对涉及外泌汗腺汗液分泌的神经传导体系、各类离子通道等进行综述，以期为损伤汗腺再生修复及干细胞转化研究提供一定的理论依据。
- 外分泌汗腺 /
- 离子通道 /
- 皮肤 /
- 汗液分泌 /
- 神经调控
Abstract: Sweat glands are widely distributed in human skin, among which eccrine sweat glands play major roles in heat dissipation and sweat secretion. Sweat secretion is mainly regulated by nervous system and includes two processes of secretion of secretory coil and reabsorption of sweat duct, involving various ion channels and proteins such as calcium ion channel, potassium ion channel, sodium-potassium-chloride co-transporter 1, Best2 protein, aquaporin 5, cystic fibrosis transmembrane conductance regulator, and epithelial sodium ion channel. This paper reviews the nerve conduction system and various ion channels involved in sweat secretion of exocrine sweat glands in order to provide a theoretical basis for the study of regeneration, repair, and transformation of stem cells.
- Eccrine glands /
- Ion channels /
- Skin /
- Sweat secretion /
- Neural regulation
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