氢氟酸烧伤救治研究进展

毛书雷; 张元海; 吴军梅; 叶春江; 倪良方; 王新刚; 王荣娟; 张建芬

doi:10.3760/cma.j.cn501120-20210623-00224

氢氟酸烧伤救治研究进展

doi: 10.3760/cma.j.cn501120-20210623-00224

1.
浙江衢化医院烧伤整形科，衢州　　324004
2.
浙江大学医学院附属第二医院烧伤与创面修复科，杭州　　310009

基金项目:

浙江省严重创伤与烧伤诊治重点实验室开放课题 2022K03

衢州市科技计划指导性项目 2019104

详细信息

通讯作者:
张建芬，Email：zjfssk@163.com

计量
- 文章访问数: 323
- HTML全文浏览量: 73
- PDF下载量: 53
- 被引次数: 0
出版历程
- 收稿日期: 2021-06-23

Research advances on the treatment of hydrofluoric acid burns

1.
Department of Burns and Plastic Surgery, Zhejiang Quhua Hospital, Quzhou 324004, China
2.
Department of BurnsWound Repair, the Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, China

Funds:

Open Project of Key Laboratory of the Diagnosis and Treatment of Severe Trauma and Burn of Zhejiang Province 2022K03

Guiding Project of Quzhou Science and Technology Plan 2019104

More Information

Corresponding author: Zhang Jianfen, Email: zjfssk@163.com

摘要

摘要: 氢氟酸是一种高度危险、有剧毒的无机酸，在工业领域和日常生活中被广泛应用。氢氟酸烧伤的危险性与氢氟酸质量分数、接触氢氟酸的持续时间、烧伤面积、烧伤深度和烧伤部位等有关。氢氟酸的毒性及组织穿透能力强，即使小面积氢氟酸烧伤，短时间内也可导致死亡。因此，提高对氢氟酸烧伤机制的认识，学习不同部位氢氟酸烧伤的治疗，可进一步提高氢氟酸烧伤的救治成功率。
- 烧伤，化学 /
- 氢氟酸 /
- 葡萄糖酸钙 /
- 静脉灌注 /
- 动脉灌注
Abstract: Hydrofluoric acid is a highly dangerous and toxic inorganic acid, which is widely used in industrial fields and daily life. The risk of hydrofluoric acid burns is related to hydrofluoric acid mass fraction, duration of exposure to hydrofluoric acid, burn area, burn depth, and burn site, etc. Hydrofluoric acid has strong toxicity and tissue penetration ability. A small area of hydrofluoric acid burns can cause death in a short time. Therefore, improving the understanding of the mechanism of hydrofluoric acid burns and learning how to treat hydrofluoric acid burns in different sites can further improve the cure rate of hydrofluoric acid burns.
- Burns, chemical /
- Hydrofluoric acid /
- Calcium gluconate /
- Intravenous perfusion /
- Arterial perfusion
所有作者均声明不存在利益冲突

HTML全文

参考文献(28)

[1]	HoffmannS, ParikhP, BohnenbergerK. Dermal hydrofluoric acid toxicity case review:looks can be deceiving[J].J Emerg Nurs,2021,47(1):28-32.DOI: 10.1016/j.jen.2020.08.005.
[2]	田鹏飞,张建芬,胡祖良,等.浙西地区316例职业性氢氟酸灼伤病例流行病学分析[J].环境与职业医学,2018,35(6):578-581.DOI: 10.13213/j.cnki.jeom.2018.17631.
[3]	YeC,WangX,ZhangY,et al.Ten-year epidemiology of chemical burns in western Zhejiang Province, China[J].Burns,2016,42(3):668-674.DOI: 10.1016/j.burns.2015.12.004.
[4]	ZhangY,WangX,SharmaK,et al.Injuries following a serious hydrofluoric acid leak: first aid and lessons[J].Burns,2015,41(7):1593-1598.DOI: 10.1016/j.burns.2015.04.002.
[5]	BurgherF,MathieuL,LatiE,et al.Experimental 70% hydrofluoric acid burns: histological observations in an established human skin explants ex vivo model[J].Cutan Ocul Toxicol,2011,30(2):100-107.DOI: 10.3109/15569527.2010.533316.
[6]	StukeLE,ArnoldoBD,HuntJL,et al.Hydrofluoric acid burns: a 15-year experience[J].J Burn Care Res,2008,29(6):893-896.DOI: 10.1097/BCR.0b013e31818b9de6.
[7]	OzcanM,AllahbeickaraghiA,DündarM.Possible hazardous effects of hydrofluoric acid and recommendations for treatment approach: a review[J].Clin Oral Investig,2012,16(1):15-23.DOI: 10.1007/s00784-011-0636-6.
[8]	WedlerV,GuggenheimM,MoronM,et al.Extensive hydrofluoric acid injuries: a serious problem[J].J Trauma,2005,58(4):852-857.DOI: 10.1097/01.ta.0000114528.15627.65.
[9]	马捷,邓津菊,吴健,等.氢氟酸烧伤的临床表现及治疗进展[J/CD].中华损伤与修复杂志:电子版,2019,14(6):466-470.DOI: 10.3877/cma.j.issn.1673-9450.2019.06.015.
[10]	王新刚,张元海,韩春茂.氢氟酸烧伤的致伤机制及其治疗的研究进展[J].中华急诊医学杂志,2014,23(11):1295-1297.DOI: 10.3760/cma.j.issn.1671-0282.2014.11.029.
[11]	张建芬,王新刚,张元海,等.氢氟酸烧伤患者检测尿氟的临床意义[J].中华急诊医学杂志,2015,24(3):328-329.DOI: 10.3760/cma.j.issn.1671-0282.2015.03.022.
[12]	ZhangY,HanC,QiuX,et al.Response to "Chemical injuries caused by the hydrofluoric acid leak"[J].Burns,2016,42(3):706-708.DOI: 10.1016/j.burns.2016.01.016.
[13]	田鹏飞,王新刚,张元海,等.316例氢氟酸烧伤患者临床特征分析[J].中华烧伤杂志,2018,34(5):271-276.DOI: 10.3760/cma.j.issn.1009-2587.2018.05.004.
[14]	TanHH,TeoS,TsengHC.Work-related chemical exposures presenting to an emergency department in Singapore[J].Occup Med (Lond),2014,64(2):113-119.DOI: 10.1093/occmed/kqt158.
[15]	HatzifotisM,WilliamsA,MullerM,et al.Hydrofluoric acid burns[J].Burns,2004,30(2):156-159.DOI: 10.1016/j.burns.2003.09.031.
[16]	张元海,王新刚,田鹏飞,等.改良葡萄糖酸钙给药剂量对非手足部的氢氟酸烧伤患者的治疗效果分析[J].中华烧伤杂志,2018,34(5):277-282.DOI: 10.3760/cma.j.issn.1009-2587.2018.05.005.
[17]	张元海,叶春江,刘利平,等.手部氢氟酸烧伤106例临床分析[J].中华烧伤杂志,2009,25(4):273-274.DOI: 10.3760/cma.j.issn.1009-2587.2009.04.013.
[18]	张曼佳, 毛书雷, 张建芬, 等. 229例手部氢氟酸烧伤患者的流行病学特征和治疗结局分析 [J] . 中华烧伤与创面修复杂志, 2022, 38(2) : 156-164. DOI: 10.3760/cma.j.cn501120-20210517-00188.
[19]	FangH,WangGY,WangX,et al.Potentially fatal electrolyte imbalance caused by severe hydrofluoric acid burns combined with inhalation injury: a case report[J].World J Clin Cases,2019,7(20):3341-3346.DOI: 10.12998/wjcc.v7.i20.3341.
[20]	ChoeM,LeeMJ,SeoKS,et al.Application of calcium nebulization for mass exposure to an accidental hydrofluoric acid spill[J].Burns,2020,46(6):1337-1346.DOI: 10.1016/j.burns.2020.02.015.
[21]	孙培培,孙静海,应莺,等.六氟灵对兔眼氢氟酸灼伤应急洗消作用研究[J].中国职业医学,2014(2):163-167.DOI: 10.11763/j.issn.2095-2619.2014.02.009.
[22]	SpölerF,FrentzM,FörstM,et al.Analysis of hydrofluoric acid penetration and decontamination of the eye by means of time-resolved optical coherence tomography[J].Burns,2008,34(4):549-555.DOI: 10.1016/j.burns.2007.05.004.
[23]	AtleyK,RidyardE.Treatment of hydrofluoric acid exposure to the eye[J].Int J Ophthalmol,2015,8(1):157-161.DOI: 10.3980/j.issn.2222-3959.2015.01.28.
[24]	HuW,YangM,ChangJ,et al.Laser doppler perfusion imaging of skin territory to reflect autonomic functional recovery following sciatic nerve autografting repair in rats[J].Microsurgery,2012,32(2):136-143.DOI: 10.1002/micr.20974.
[25]	毛书雷, 张建芬, 叶春江, 等. 成功救治危重氢氟酸烧伤1例 [J/OL] . 中国临床案例成果数据库, 2022, 4(1): E03877[2022-09-05]. http://rs.yiigle.com/CN119999202201/1389378.htm.DOI: 10.3760/cma.j.cmcr.2022.e03877.
[26]	VohraR,VelezLI,RiveraW,et al.Recurrent life-threatening ventricular dysrhythmias associated with acute hydrofluoric acid ingestion: observations in one case and implications for mechanism of toxicity[J].Clin Toxicol (Phila),2008,46(1):79-84.DOI: 10.1080/15563650701639097.
[27]	ZhangY,WangX,LiuY,et al.Management of a rare case with severe hydrofluoric acid burns: important roles of neutralizers and continuous renal replacement therapy[J].Int J Low Extrem Wounds,2017,16(4):289-295.DOI: 10.1177/1534734617736198.
[28]	张元海, 田鹏飞, 张惟, 等. 急救网络建设在危重氢氟酸烧伤患者早期救治中的作用 [J] . 中华烧伤杂志, 2021, 37(10): 921-928. DOI: 10.3760/cma.j.cn501120-20210707-00237.