诱导多能干细胞促进糖尿病足溃疡愈合的研究进展

高春辰; 陈金安; 王爱萍

doi:10.3760/cma.j.cn501120-20210630-00230

诱导多能干细胞促进糖尿病足溃疡愈合的研究进展

doi: 10.3760/cma.j.cn501120-20210630-00230

东部战区空军医院内分泌科，糖尿病足中心，南京　　210002

基金项目:

国家自然科学基金面上项目 81770810

详细信息

通讯作者:
王爱萍，Email：wap454hospital@hotmail.com

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出版历程
- 收稿日期: 2022-06-30

Research progress of induced pluripotent stem cells in promoting wound healing of diabetic foot ulcers

Funds:

General Program of National Natural Science Foundation of China 81770810

摘要

摘要: 糖尿病足溃疡等慢性创伤在人群中广泛流行，给患者和社会都带来了巨大的负担。而在现有的治疗方式下，糖尿病足溃疡往往愈合不良且容易复发，因此找寻新型疗法显得尤为迫切和重要。干细胞疗法作为一种新兴的治疗方式，其在糖尿病足溃疡愈合中的作用已得到大量基础和临床研究的证实。然而，由于获取干细胞往往依赖于侵入性手段，免疫排斥和移植后的细胞存活率低等问题也限制了干细胞疗法的大规模应用和推广。近年来，随着诱导多能干细胞（iPSC）技术的发展和进步，其在糖尿病足溃疡的治疗中表现出很强的转化潜能。该文将围绕iPSC在包括糖尿病溃疡和肢体缺血在内的创伤愈合动物模型中的应用及前景、临床应用的局限性和改善安全性的方法展开综述。
- 糖尿病足 /
- 溃疡 /
- 诱导多能干细胞 /
- 干细胞移植 /
- 创面修复
Abstract: Chronic wounds such as diabetic foot ulcers are epidemic, which bring huge burdens to both the patients and the society. However, with current treatment methods, diabetic foot ulcers often heal poorly and recur frequently, so it is urgent and important to find new and advanced therapies. Stem cell therapy has been proved by a large number of pre-clinical and clinical studies as a potential treatment for chronic wounds. However, the acquisition of stem cells often depends on invasive techniques, and immunogenicity and limited cell survival in vivo also limit the large-scale application and promotion of stem cell therapy. In the recent years, with the development and advance of induced pluripotent stem cell (iPSC) technology, it has shown a strong translational potential in the treatment of chronic wounds such as diabetic foot ulcers. This article reviews the applications and prospect of iPSCs in animal wound healing models including diabetic ulcers and limb ischemia, the limitations of their clinical application, and the methods to improve their safety.
- Diabetic foot /
- Ulcer /
- Induced pluripotent stem cells /
- Stem cell transplantation /
- Wound repair
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