酸性成纤维细胞生长因子在促进创面愈合中的作用研究进展

王洪涛; 韩军涛; 胡大海

doi:10.3760/cma.j.cn501120-20210811-00276

酸性成纤维细胞生长因子在促进创面愈合中的作用研究进展

doi: 10.3760/cma.j.cn501120-20210811-00276

空军军医大学第一附属医院全军烧伤中心，烧伤与皮肤外科，西安　　710032

基金项目:

国家自然科学基金面上项目 81971835

上海王正国创伤医学发展基金会生长因子复兴计划 SZYZ-TR-07

详细信息

通讯作者:
王洪涛，Email：wanght@fmmu.edu.cn

计量
- 文章访问数: 348
- HTML全文浏览量: 120
- PDF下载量: 98
- 被引次数: 0
出版历程
- 收稿日期: 2021-08-11

Research advances on the role of acid fibroblast growth factor in promotion of wound healing

Department of Burns and Cutaneous Surgery, Burn Center of PLA, the First Affiliated Hospital of Air Force Medical University, Xi'an 710032, China

Funds:

General Program of National Natural Science Foundation of China 81971835

Shanghai Wang Zhengguo Foundation for Traumatic Medicine Growth Factor Rejuvenation Plan SZYZ-TR-07

More Information

Corresponding author: Wang Hongtao, Email: wanght@fmmu.edu.cn

摘要

摘要: 酸性成纤维细胞生长因子（aFGF）是成纤维细胞生长因子（FGF）家族成员之一，具有广泛地促进胚胎发育、创面愈合、血管再生、神经损伤修复，以及调控免疫代谢的作用。创面愈合包含了炎症反应、新生血管形成、修复细胞的增殖与迁移、胶原等ECM的沉积等病理生理过程。该文在查阅近年来相关文献的基础上，围绕aFGF在传导生物信号、调节细胞生长、参与组织修复中的作用及相关机制研究进展进行综述，并从临床药代动力学和安全性角度，对aFGF的当前研究热点和未来临床应用方向进行展望。
- 成纤维细胞生长因子1 /
- 炎症 /
- 药物释放系统 /
- 皮肤 /
- 新生血管化，生理性 /
- 创面修复
Abstract: Acid fibroblast growth factor (aFGF) is a member of fibroblast growth factors (FGF) family, widely promoting embryonic development, wound healing, vascular regeneration, nerve injury repair, as well as regulating immune metabolism. Many pathophysiological processes, such as inflammation, neovascularization, proliferation and migration of repair cells, and deposition of collagen and other extracellular matrix are involved in the process of wound healing. Based on the relevant literature in recent years, this article mainly reviews the research progresses on the roles and mechanism of aFGF in biological signal transduction, regulation of cell growth, and involvement in tissue repair, and discusses the current research hot spots as well as the prospective future direction of clinical applications of aFGF in the aspect of clinical pharmacokinetics and safety.
- Fibroblast growth factor 1 /
- Inflammation /
- Drug delivery systems /
- Skin /
- Neovasculari-zation, physiologic /
- Wound repair
所有作者均声明不存在利益冲突

HTML全文

参考文献(42)

[1]	李校堃. 坚持梦想不负韶华:生长因子与创面修复三十年自主创新之路[J]. 中华烧伤杂志,2020,36 (3): 161-165. DOI: 10.3760/cma.j.cn501120-20200305-00125.
[2]	SluzalskaKD, SlawskiJ, SochackaM, et al. Intracellular partners of fibroblast growth factors 1 and 2 - implications for functions[J]. Cytokine Growth Factor Rev, 2021,57:93-111. DOI: 10.1016/j.cytogfr.2020.05.004.
[3]	PhanP, SaikiaBB, SonnailaS, et al. The saga of endocrine FGFs[J]. Cells, 2021, 10(9):2418. DOI: 10.3390/cells10092418.
[4]	柴家科, 孙永华, 夏照帆, 等. 酸性成纤维细胞生长因子治疗深Ⅱ度烧伤的多中心随机对照临床试验[J].中国药师,2015(4):589-591. DOI: 10.3969/j.issn.1008-049X.2015.04.019.
[5]	ZuluetaM, ChyanCL, HungSC. Structural analysis of synthetic heparan sulfate oligosaccharides with fibroblast growth factors and heparin-binding hemagglutinin[J]. Curr Opin Struct Biol, 2018,50:126-133. DOI: 10.1016/j.sbi.2018.03.003.
[6]	ZakrzewskaM, OpalinskiL, HaugstenEM, et al. Crosstalk between p38 and Erk 1/2 in downregulation of FGF1-induced signaling[J]. Int J Mol Sci, 2019,20(8):1826. DOI: 10.3390/ijms20081826.
[7]	KostasM, LampartA, BoberJ, et al. Translocation of exogenous FGF1 and FGF2 protects the cell against apoptosis independently of receptor activation[J]. J Mol Biol, 2018,430(21):4087-4101. DOI: 10.1016/j.jmb.2018.08.004.
[8]	YamakawaS, HayashidaK. Advances in surgical applications of growth factors for wound healing[J/OL]. Burns Trauma, 2019,7:10[2021-12-03]. https://pubmed.ncbi.nlm.nih.gov/30993143/. DOI: 10.1186/s41038-019-0148-1.
[9]	李校堃, 许华, 付小兵, 等. 重组人酸性成纤维细胞生长因子促进创伤愈合的研究[J].中国药科大学学报,2002,33(4):312-315. DOI: 10.3321/j.issn:1000-5048.2002.04.014.
[10]	MaB, ChengDS, XiaZF, et al. Randomized, multicenter, double-blind, and placebo-controlled trial using topical recombinant human acidic fibroblast growth factor for deep partial-thickness burns and skin graft donor site[J]. Wound Repair Regen, 2007,15(6):795-799. DOI: 10.1111/j.1524-475X.2007.00307.x.
[11]	XuJ, MinD, GuoG, et al. Experimental study of epidermal growth factor and acidic fibroblast growth factor in the treatment of diabetic foot wounds[J]. Exp Ther Med, 2018,15(6):5365-5370. DOI: 10.3892/etm.2018.6131.
[12]	孙赛, 张碧芳, 陈容容, 等. 重组人酸性成纤维细胞生长因子联合超脉冲二氧化碳激光治疗色素痣的临床疗效观察[J].中国医药科学,2019,9(24):65-68. DOI: 10.3969/j.issn.2095-0616.2019.24.017.
[13]	AlongeKM, MirzadehZ, ScarlettJM, et al. Hypothalamic perineuronal net assembly is required for sustained diabetes remission induced by fibroblast growth factor 1 in rats[J]. Nat Metab, 2020,2(10):1025-1033. DOI: 10.1038/s42255-020-00275-6.
[14]	Bruczko-GoralewskaM, RomanowiczL, BączykJ, et al. Peptide growth factors and their receptors in the vein wall[J]. J Investig Med, 2019,67(8):1149-1154. DOI: 10.1136/jim-2019-001075.
[15]	ZouY, HuJ, HuangW, et al. Non-mitogenic fibroblast growth factor 1 enhanced angiogenesis following ischemic stroke by regulating the sphingosine-1-phosphate 1 pathway[J]. Front Pharmacol, 2020,11:59. DOI: 10.3389/fphar.2020.00059.
[16]	ChengX, WangZ, YangJ, et al. Acidic fibroblast growth factor delivered intranasally induces neurogenesis and angiogenesis in rats after ischemic stroke[J]. Neurol Res, 2011,33(7):675-680. DOI: 10.1179/1743132810Y.0000000004.
[17]	FayazzadehE, YavarifarH, RafieSR, et al. Fibroblast growth factor-1 vs. fibroblast growth factor-2 in ischemic skin flap survival in a rat animal model[J]. World J Plast Surg, 2016,5(3):274-279.
[18]	AkbariH, AhmadiM, FatemiMJ, et al. The role of recombinant fibroblast growth factor 1 in enhancing the angiogenesis in random cutaneous flaps in animal model of rat[J]. World J Plast Surg, 2021,10(2):76-81. DOI: 10.29252/wjps.10.2.76.
[19]	ChaH, HongS, ParkJH, et al. Stem cell-derived exosomes and nanovesicles: promotion of cell proliferation, migration, and anti-Senescence for treatment of wound damage and skin ageing[J]. Pharmaceutics, 2020,12(12):1135. DOI: 10.3390/pharmaceutics12121135.
[20]	WangJ, LiuS, LiJ, et al. The role of the fibroblast growth factor family in bone-related diseases[J]. Chem Biol Drug Des, 2019,94(4):1740-1749. DOI: 10.1111/cbdd.13588.
[21]	XueYN, YanY, ChenZZ, et al. LncRNA TUG1 regulates FGF1 to enhance endothelial differentiation of adipose-derived stem cells by sponging miR-143[J]. J Cell Biochem, 2019,120(11):19087-19097. DOI: 10.1002/jcb.29232.
[22]	HoseiniSJ, GhazaviH, ForouzanfarF, et al. Fibroblast growth factor 1-transfected adipose-derived mesenchymal stem cells promote angiogenic proliferation[J]. DNA Cell Biol, 2017,36(5):401-412. DOI: 10.1089/dna.2016.3546.
[23]	GuanJT, LiXX, PengDW, et al. MicroRNA-18a-5p administration suppresses retinal neovascularization by targeting FGF1 and HIF1A[J]. Front Pharmacol, 2020,11:276. DOI: 10.3389/fphar.2020.00276.
[24]	陆超, 沈思远, 刘拓, 等. 重组人酸性成纤维细胞生长因子温敏凝胶及Rg3水凝胶促进SD大鼠烫伤创面愈合的作用机制[J].中国生物制品学杂志,2020,33(11):1240-1246,1252.
[25]	HuiQ, ZhangL, YangX, et al. Higher biostability of rh-aFGF-carbomer 940 hydrogel and its effect on wound healing in a diabetic rat model[J]. ACS Biomater Sci Eng, 2018,4(5):1661-1668. DOI: 10.1021/acsbiomaterials.8b00011.
[26]	SunJ, HuangX, NiuC, et al. aFGF alleviates diabetic endothelial dysfunction by decreasing oxidative stress via Wnt/β-catenin-mediated upregulation of HXK2[J]. Redox Biol, 2021,39:101811. DOI: 10.1016/j.redox.2020.101811.
[27]	FanL, DingL, LanJ, et al. Fibroblast growth factor-1 improves insulin resistance via repression of JNK-mediated inflammation[J]. Front Pharmacol, 2019,10:1478. DOI: 10.3389/fphar.2019.01478.
[28]	LiR, WangB, WuC, et al. Acidic fibroblast growth factor attenuates type 2 diabetes-induced demyelination via suppressing oxidative stress damage[J]. Cell Death Dis, 2021,12(1):107. DOI: 10.1038/s41419-021-03407-2.
[29]	BucurM, DincaO, VladanC, et al. Variation in expression of inflammation-related signaling molecules with profibrotic and antifibrotic effects in cutaneous and oral mucosa scars[J]. J Immunol Res, 2018,2018:5196023. DOI: 10.1155/2018/5196023.
[30]	ShimboriC, BellayePS, XiaJ, et al. Fibroblast growth factor-1 attenuates TGF-β1-induced lung fibrosis[J]. J Pathol, 2016,240(2):197-210. DOI: 10.1002/path.4768.
[31]	LiC, DengC, ZhouT, et al. MicroRNA-370 carried by M2 macrophage-derived exosomes alleviates asthma progression through inhibiting the FGF1/MAPK/STAT1 axis[J]. Int J Biol Sci, 2021,17(7):1795-1807. DOI: 10.7150/ijbs.59715.
[32]	ScheragaRG, ThompsonC, TulapurkarME, et al. Activation of heat shock response augments fibroblast growth factor-1 expression in wounded lung epithelium[J]. Am J Physiol Lung Cell Mol Physiol, 2016,311(5):L941-L955. DOI: 10.1152/ajplung.00262.2016.
[33]	KerrR, AgrawalS, MaityS, et al. Design of a thrombin resistant human acidic fibroblast growth factor (hFGF1) variant that exhibits enhanced cell proliferation activity[J]. Biochem Biophys Res Commun, 2019,518(2):191-196. DOI: 10.1016/j.bbrc.2019.08.029.
[34]	SzlachcicA, SochackaM, CzyrekA, et al. Low stability of integrin-binding deficient mutant of FGF1 restricts its biological activity[J]. Cells, 2019, 8(8):899. DOI: 10.3390/cells8080899.
[35]	翁婷婷,蔡程浩,韩春茂,等.生物材料递送生长因子调控创面修复的研究进展[J].中华烧伤与创面修复杂志,2022,38(7):691-696. DOI: 10.3760/cma.j.cn501225-20220430-00166.
[36]	ZhangJ, GeJ, XuY, et al. Bioactive multi-engineered hydrogel offers simultaneous promise against antibiotic resistance and wound damage[J]. Int J Biol Macromol, 2020,164:4466-4474. DOI: 10.1016/j.ijbiomac.2020.08.247.
[37]	TanF, RuiX, XiangX, et al. Multimodal treatment combining cold atmospheric plasma and acidic fibroblast growth factor for multi-tissue regeneration[J]. FASEB J, 2021,35(5):e21442. DOI: 10.1096/fj.202002611R.
[38]	HeS, ShiD, HanZ, et al. Heparinized silk fibroin hydrogels loading FGF1 promote the wound healing in rats with full-thickness skin excision[J]. Biomed Eng Online, 2019,18(1):97. DOI: 10.1186/s12938-019-0716-4.
[39]	WangF, WangY, TianC, et al. Fabrication of the FGF1-functionalized sericin hydrogels with cell proliferation activity for biomedical application using genetically engineered Bombyx mori (B. mori) silk[J]. Acta Biomater, 2018,79:239-252. DOI: 10.1016/j.actbio.2018.08.031.
[40]	ZhangQH, XuP, LuYX, et al. Acidic and basic fibroblast growth factor expression levels in cervical cancer and their effects on tumor cell proliferation[J]. Genet Mol Res, 2016,15(4):gmr15049043. DOI: 10.4238/gmr15049043.
[41]	HuiQ, YangR, LuC, et al. Validation of a double-sandwich enzyme-linked immunoassay for pharmacokinetic study of an rh-aFGF hydrogel in rat skin and serum[J]. Front Pharmacol, 2020,11:700. DOI: 10.3389/fphar.2020.00700.
[42]	ZhangL, HuangT, BiJ, et al. Long-term toxicity study of topical administration of a highly-stable rh-aFGF carbomer 940 hydrogel in a rabbit skin wound model[J]. Front Pharmacol, 2020,11:58. DOI: 10.3389/fphar.2020.00058.