铜绿假单胞菌噬菌体与宿主的相互作用研究进展

石茜; 曾茁; 张一鸣; 杨子晨; 彭毅志

doi:10.3760/cma.j.cn501120-20210929-00338

铜绿假单胞菌噬菌体与宿主的相互作用研究进展

doi: 10.3760/cma.j.cn501120-20210929-00338

1.
陆军军医大学（第三军医大学）第二附属医院整形美容外科，重庆　　400037
2.
陆军军医大学（第三军医大学）第一附属医院全军烧伤研究所，创伤、烧伤与复合伤国家重点实验室，重庆　　400038

基金项目:

国家自然科学基金面上项目 81772073

国家自然科学基金青年科学基金项目 82002051

创伤、烧伤与复合伤国家重点实验室开放课题基金 SKLKF201918

重庆市自然科学基金面上项目 cstc2021jcyj-msxmX0655

重庆市博士“直通车”项目 CSTB2022BSXM-JCX0019

详细信息

通讯作者:
彭毅志，Email：yizhipengtmmu@163.com

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出版历程
- 收稿日期: 2021-09-29

Research advances on the interaction between Pseudomonas aeruginosa bacteriophages and the host

1.
Department of Plastic and Cosmetic Surgery, the Second Affiliated Hospital of Army Medical University (the Third Military Medical University), Chongqing 400037, China
2.
State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Burn Research, the First Affiliated Hospital of Army Medical University (the Third Military Medical University), Chongqing 400038, China

Funds:

General Program of National Natural Science Foundation of China 81772073

Youth Science Foundation Project of National Natural Science Foundation of China 82002051

Foundation of Open Projects from State Key Laboratory of Trauma, Burns and Combined Injury SKLKF201918

General Program of Natural Science Foundation of Chongqing cstc2021jcyj-msxmX0655

Chongqing Doctor "Through Train" Project CSTB2022BSXM-JCX0019

More Information

Corresponding author: Peng Yizhi, Email: yizhipengtmmu@163.com

摘要

摘要: 铜绿假单胞菌是最常见的烧伤感染创面病原菌，它能够编码多种毒力因子，具有很强的致病性，可导致预后差、病死率高。为了研究对抗铜绿假单胞菌感染的新方法，研究者们观察了其噬菌体与宿主之间广泛的相互作用。噬菌体通过多种机制影响甚至主导宿主细菌的结构、运动、代谢，促进宿主进化，也是影响宿主环境适应性和致病性的重要因素。该文分别从单细胞水平和群体水平对铜绿假单胞菌噬菌体与宿主的相互作用进行了综述。了解这些相互作用可为铜绿假单胞菌临床感染的治疗研究提供新的思路，为未来研发抗菌制剂以及指导烧伤感染治疗提供基础。
- 铜绿假单胞菌 /
- 细菌噬菌体 /
- 宿主与病原体相互作用 /
- 烧伤 /
- 感染
Abstract: Pseudomonas aeruginosa is the most common pathogen of burn wound infection. It can encode a variety of virulence factors and is highly pathogenic, which can lead to poor prognosis and high mortality. In order to research a new method to combat Pseudomonas aeruginosa infection, researchers have observed a wide range of interactions between the bacteriophages and the host. Bacteriophages influence and even dominate the structure, movement, and metabolism of host bacteria through a variety of mechanisms, catalyze the evolution of the host, and are also an important factor in host environmental adaptability and pathogenicity. In this paper, the interaction between Pseudomonas aeruginosa bacteriophages and the host is reviewed from the single cell level and the population level. Understanding these interactions could provide new idea for the treatment of Pseudomonas aeruginosa clinical infections, provides a basis for future development of antimicrobial agents and guides the treatment of burn infections.
- Pseudomonas aeruginosa /
- Bacterio-phages /
- Host-pathogen interactions /
- Burns /
- Infection
所有作者均声明不存在利益冲突

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