新型生物活性材料促进创面修复和皮肤再生

吕国忠; 赵朋

doi:10.3760/cma.j.cn501120-20211029-00373

新型生物活性材料促进创面修复和皮肤再生

doi: 10.3760/cma.j.cn501120-20211029-00373

吕国忠^,,
赵朋

江南大学附属医院烧创伤诊疗中心，教育部创面修复技术工程研究中心，无锡　　214122

基金项目:

国家自然科学基金面上项目 81671912

江苏省科技厅社会发展临床前沿技术项目 BE2018626

详细信息

通讯作者:
吕国忠，Email：luguozhong@hotmail.com

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出版历程
- 收稿日期: 2021-10-29

New bioactive materials for promoting wound repair and skin regeneration

Lyu Guozhong^,,
Zhao Peng

Engineering Research Center of the Ministry of Education for Wound Repair Technology, Treatment Center of Burns and Trauma, the Affiliated Hospital of Jiangnan University, Wuxi 214122, China

Funds:

General Program of National Natural Science Foundation of China 81671912

Clinical Frontier Technology Program of Social Development of Science and Technology Agency of Jiangsu Province of China BE2018626

More Information

Corresponding author: Lyu Guozhong, Email: luguozhong@hotmail.com

摘要

摘要: 微环境调控是促进创面修复和皮肤再生的关键技术。近年来，系列调控微环境和细胞行为的新型生物活性材料得以研发，显示出高效诱导创面修复和皮肤附件再生的能力。本文就相关新型生物活性材料的研究进展及其作用机制进行总结。
- 生物相容性材料 /
- 伤口愈合 /
- 皮肤 /
- 再生 /
- 微环境
Abstract: The modulation of microenvironment is a key technology towards promoting wound repair and skin regeneration. In recent years, a series of new bioactive materials that modulate the microenvironment and cell behaviors have been developed, demonstrating highly efficient capability of inducing wound repair and skin appendage regeneration. This article summarizes the research development of related new bioactive materials and their mechanisms of action.
- Biocompatible materials /
- Wound healing /
- Skin /
- Regeneration /
- Microenvironment
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参考文献(40)

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脱细胞真皮基质（ADM）	重症监护病房（ICU）	动脉血氧分压（PaO₂）
丙氨酸转氨酶（ALT）	白细胞介素（IL）	磷酸盐缓冲液（PBS）
急性呼吸窘迫综合征（ARDS）	角质形成细胞（KC）	反转录-聚合酶链反应（RT-PCR）
天冬氨酸转氨酶（AST）	半数致死烧伤面积（LA50）	全身炎症反应综合征（SIRS）
集落形成单位（CFU）	内毒素/脂多糖（LPS）	超氧化物歧化酶（SOD）
细胞外基质（ECM）	丝裂原活化蛋白激酶（MAPK）	动脉血氧饱和度（SaO₂）
表皮生长因子（EGF）	最低抑菌浓度（MIC）	体表总面积（TBSA）
酶联免疫吸附测定（ELISA）	多器官功能障碍综合征（MODS）	转化生长因子（TGF）
成纤维细胞（Fb）	多器官功能衰竭（MOF）	辅助性T淋巴细胞（Th）
成纤维细胞生长因子（FGF）	一氧化氮合酶（NOS）	肿瘤坏死因子（TNF）
3-磷酸甘油醛脱氢酶（GAPDH）	负压伤口疗法（NPWT）	血管内皮生长因子（VEGF）
苏木精-伊红（HE）	动脉血二氧化碳分压（PaCO₂）	负压封闭引流（VSD）