皮肤触觉感受器默克尔细胞功能研究进展

袁绘普; 丁圆圆; 郑懿欣; 张雅君; 刘霞; 芮晨; 王超尘; 肖瑛

doi:10.3760/cma.j.cn501120-20211209-00409

皮肤触觉感受器默克尔细胞功能研究进展

doi: 10.3760/cma.j.cn501120-20211209-00409

1.
浙江大学医学院附属邵逸夫医院生物医学研究中心，杭州　　310020
2.
中国科学院上海药物研究所安全评价研究中心，上海　　201203
3.
浙江大学爱丁堡大学联合学院，海宁　　314400

基金项目:

国家自然科学基金面上项目 32070816

浙江省自然科学基金 LQ22C070002

详细信息

通讯作者:
肖瑛，Email：xiaoying.srr@zju.edu.cn

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- 被引次数: 0
出版历程
- 收稿日期: 2021-12-09

Research advances on the function of skin touch receptor Merkel cells

1.
Biomedical Research Center, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310020, China
2.
Centre for Drug Safety Evaluation and Research, Shanghai Institute of Materia Medica, Chinese Academy of Science, Shanghai 201203, China
3.
Union College of Edinburgh University, Zhejiang University, Haining 314400, China

Funds:

General Program of National Natural Science Foundation of China 32070816

Natural Science Foundation of Zhejiang Province of China LQ22C070002

More Information

Corresponding author: Xiao Ying, Email: xiaoying.srr@zju.edu.cn

摘要

摘要: 在由烧伤等因素导致的皮肤损伤修复过程中，触觉功能的重建离不开触觉感受器默克尔细胞的功能再生。默克尔细胞主要存在于表皮基底层，与神经紧密相连形成默克尔细胞-神经复合体，在生物机体内发挥重要作用。大量研究表明默克尔细胞通过机械门控离子通道PIEZO2对机械力刺激进行精确传导，行使触觉感受器的功能。该文通过论述默克尔细胞的特征，分析该类细胞可能存在的不同亚群及其功能，同时调研了触觉相关疾病的动物模型研究和触觉相关的临床疾病，揭示了默克尔细胞功能研究的重要性。
- 皮肤 /
- 默克尔细胞 /
- 触觉 /
- 感受器 /
- PIEZO2
Abstract: The reconstruction of tactile function during the repair of skin damage caused by factors including burns is inseparable from the functional regeneration of tactile receptor Merkel cells. Merkel cells mainly exist in the basal layer of the epidermis and are closely connected with nerves to form Merkel cell-nerve complexes, which play an important role in biological organisms. A large number of studies have shown that Merkel cells conduct precise transmission of mechanical force stimuli through the mechanically gated ion channels PIEZO2, and perform the function of tactile receptors. In this paper, we discussed the characteristics of Merkel cells and analyzed the different subgroups that may possibly exist in this type of cells and their functions, at the same time, we investigated the animal model research of touch-related diseases and the clinical diseases related to touch, revealing the importance of Merkel cell function research.
- Skin /
- Merkel cells /
- Touch /
- Sensilla /
- PIEZO2
所有作者均声明不存在利益冲突

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参考文献(46)

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