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皮肤γδT细胞各亚群在创面再上皮化过程中的调控作用及其相关机制

贺伟峰

贺伟峰. 皮肤γδT细胞各亚群在创面再上皮化过程中的调控作用及其相关机制[J]. 中华烧伤与创面修复杂志, 2022, 38(2): 114-118. DOI: 10.3760/cma.j.cn501120-20211210-00411.
引用本文: 贺伟峰. 皮肤γδT细胞各亚群在创面再上皮化过程中的调控作用及其相关机制[J]. 中华烧伤与创面修复杂志, 2022, 38(2): 114-118. DOI: 10.3760/cma.j.cn501120-20211210-00411.
He WF.Regulatory role and related mechanism of skin gamma-delta T cell subsets in wound re-epithelialization[J].Chin J Burns Wounds,2022,38(2):114-118.DOI: 10.3760/cma.j.cn501120-20211210-00411.
Citation: He WF.Regulatory role and related mechanism of skin gamma-delta T cell subsets in wound re-epithelialization[J].Chin J Burns Wounds,2022,38(2):114-118.DOI: 10.3760/cma.j.cn501120-20211210-00411.

皮肤γδT细胞各亚群在创面再上皮化过程中的调控作用及其相关机制

doi: 10.3760/cma.j.cn501120-20211210-00411
基金项目: 

国家自然科学基金面上项目 31872742, 82172232

军队医学科技青年培育计划 20QNPY024

陆军军医大学科技创新能力提升专项 2019XQY12

详细信息
    通讯作者:

    Email:whe761211@hotmail.com

Regulatory role and related mechanism of skin gamma-delta T cell subsets in wound re-epithelialization

Funds: 

General Program of National Natural Science Foundation of China 31872742, 82172232

Military Medical Science and Technology Youth Training Program 20QNPY024

Science and Technology Innovation Capability Improvement Project of Army Military Medical University 2019XQY12

More Information
    Corresponding author: Email: whe761211@hotmail.com
  • 摘要:

    再上皮化过程是决定皮肤创面愈合进程的核心环节之一。表皮干细胞增殖分化形成新生表皮组织是再上皮化的组织学基础,而表皮干细胞—前体细胞—终末细胞这一细胞分化过程顺利进行是新生表皮组织不断形成的细胞学基础。表皮干细胞增殖及分化为前体细胞是新生表皮组织增殖潜力的决定因素,而前体细胞扩增及分化为终末细胞是决定新生表皮组织形成速度的关键因素。组织微环境在创面再上皮化过程中发挥关键的调控作用,而细胞生长因子和炎症介质是构成创面组织微环境的2个重要组成成分,分别在表皮干细胞增殖分化的不同环节发挥调节作用,协同促进创面再上皮化顺利进行。γδT细胞是皮肤免疫系统中的重要组成部分,其不同亚群分别通过分泌生长因子和炎症因子在动态塑造早期创面微环境中起关键作用。本文从创面免疫微环境的角度出发,简要论述皮肤γδT细胞在维持表皮干细胞增殖分化平衡以及调控创面再上皮化中的作用,为难愈性创面的预防及治疗提供新方向。

     

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  • 收稿日期:  2021-12-10

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