严重烧伤感染与细胞因子风暴的研究进展

陈仲毅; 胡时强; 刘德伍; 张红艳; 郭光华; 毛远桂

doi:10.3760/cma.j.cn501225-20220412-00134

严重烧伤感染与细胞因子风暴的研究进展

doi: 10.3760/cma.j.cn501225-20220412-00134

南昌大学第一附属医院烧伤整形与创面修复医学中心，南昌　　330006

基金项目:

国家自然科学基金地区科学基金项目 81460293

详细信息

通讯作者:
毛远桂，Email：yuanguimao64@163.com

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出版历程
- 收稿日期: 2022-04-12

Research advances on severe burn infection and cytokine storm

Medical Center of Burn Plastic and Wound Repair, the First Affiliated Hospital of Nanchang University, Nanchang 330006, China

Funds:

Regional Science Fund Project of National Natural Science Foundation of China 81460293

More Information

Corresponding author: Mao Yuangui, Email: yuanguimao64@163.com

摘要

摘要: 严重烧伤的致死率一直处于较高水平。大量研究表明，严重烧伤患者快速出现感染症状、病情进展迅速与细胞因子风暴的发生密切相关，然而临床实践中对细胞因子风暴的监测预警及对症治疗尚处于探索阶段。该文就细胞因子风暴及关联的细胞因子、烧伤感染诱发细胞因子风暴的机制、预警及治疗进行综述，旨在为减轻严重烧伤患者感染程度、降低病死概率提供临床参考建议。
- 烧伤 /
- 感染 /
- 细胞因子风暴 /
- 发病机制 /
- 治疗
Abstract: Mortality due to severe burns has always been at a high level. A large number of studies have shown that the rapid onset of infectious symptoms and rapid progression of severely burned patients are closely related to the occurrence of cytokine storm. However, in clinical practice, cytokine storm monitoring, early warning, and symptomatic treatment are still in exploratory stage. This article reviews the cytokine storm and its related cytokines, the mechanism, early warning, and treatment of cytokine storm induced by burn infection, aiming to provide clinical references for reducing infection and mortality in severely burned patients.
- Burns /
- Infection /
- Cytokine storm /
- Pathogenesis /
- Therapies
所有作者均声明不存在利益冲突

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表1 与细胞因子风暴相关联的6类细胞因子及其功能

类型	主要细胞因子	功能
CSF	G-CSF、M-CSF、GM-CSF	刺激炎症细胞增殖和分化
IL	IL-1~40	活化或诱导免疫细胞增殖和分化
趋化因子	CCL1~19、CXCL10/IP-10、CXCL12、CX3CL1	控制所有免疫细胞的迁移和归巢，参与炎症反应
干扰素	α干扰素、β干扰素、γ干扰素	激活巨噬细胞，诱导上皮细胞凋亡
生长因子	IGF、TGF-β、EGF、PDGF	促进细胞生长、分化和个体发育
TNF	TNF-α、TNF-β	促进炎症反应，激活细胞毒性Ｔ淋巴细胞，调控细胞的增殖、存活、分化和凋亡
注：CSF为集落刺激因子，IL为白细胞介素，TNF为肿瘤坏死因子，G-CSF为粒细胞集落刺激因子，M-CSF为巨噬细胞集落刺激因子，GM-CSF为粒细胞巨噬细胞集落刺激因子，IP-10为γ干扰素诱导蛋白10，IGF为胰岛素样生长因子，TGF-β为转化生长因子β，EGF为表皮生长因子，PDGF为血小板衍生生长因子

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