生长因子调控创面修复的进展与思考

肖健 张凡

肖健, 张凡. 生长因子调控创面修复的进展与思考[J]. 中华烧伤与创面修复杂志, 2022, 38(7): 610-615. DOI: 10.3760/cma.j.cn501225-20220416-00139.
引用本文: 肖健, 张凡. 生长因子调控创面修复的进展与思考[J]. 中华烧伤与创面修复杂志, 2022, 38(7): 610-615. DOI: 10.3760/cma.j.cn501225-20220416-00139.
Xiao J,Zhang F.Progress and thoughts on the regulation of wound repair by growth factors[J].Chin J Burns Wounds,2022,38(7):610-615.DOI: 10.3760/cma.j.cn501225-20220416-00139.
Citation: Xiao J,Zhang F.Progress and thoughts on the regulation of wound repair by growth factors[J].Chin J Burns Wounds,2022,38(7):610-615.DOI: 10.3760/cma.j.cn501225-20220416-00139.

生长因子调控创面修复的进展与思考

doi: 10.3760/cma.j.cn501225-20220416-00139
基金项目: 

国家自然科学基金优秀青年科学基金项目 81722028

温州市重大科技创新攻关项目 ZY2020023

详细信息
    通讯作者:

    肖健,Email:xfxj2000@126.com

Progress and thoughts on the regulation of wound repair by growth factors

Funds: 

Excellent Young Program of National Natural Science Foundation of China 81722028

Wenzhou Science and Technology Innovation Project ZY2020023

More Information
  • 摘要: 生长因子在创面愈合中起重要调控作用,其主要通过激活相关信号通路加速创面愈合。中国科学家对生长因子的基础、临床研究至今已有30年历史,研发的生长因子系列药物被广泛应用于烧创伤及慢性难愈合溃疡的治疗。该文从免疫、神经、脂肪等多个角度阐述了生长因子对创面修复的前沿进展,并提出了该研究团队对生长因子调控创面修复的进一步思考。

     

  • 脱细胞真皮基质(ADM)重症监护病房(ICU)动脉血氧分压(PaO2
    丙氨酸转氨酶(ALT)白细胞介素(IL)磷酸盐缓冲液(PBS)
    急性呼吸窘迫综合征(ARDS)角质形成细胞(KC)反转录-聚合酶链反应(RT-PCR)
    天冬氨酸转氨酶(AST)半数致死烧伤面积(LA50)全身炎症反应综合征(SIRS)
    集落形成单位(CFU)内毒素/脂多糖(LPS)超氧化物歧化酶(SOD)
    细胞外基质(ECM)丝裂原活化蛋白激酶(MAPK)动脉血氧饱和度(SaO2
    表皮生长因子(EGF)最低抑菌浓度(MIC)体表总面积(TBSA)
    酶联免疫吸附测定(ELISA)多器官功能障碍综合征(MODS)转化生长因子(TGF)
    成纤维细胞(Fb)多器官功能衰竭(MOF)辅助性T淋巴细胞(Th)
    成纤维细胞生长因子(FGF)一氧化氮合酶(NOS)肿瘤坏死因子(TNF)
    3-磷酸甘油醛脱氢酶(GAPDH)负压伤口疗法(NPWT)血管内皮生长因子(VEGF)
    苏木精-伊红(HE)动脉血二氧化碳分压(PaCO2负压封闭引流(VSD)
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  • 收稿日期:  2022-04-16

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