壳聚糖基创面敷料在创面愈合中的作用及其机制研究进展

胡宗浩; 阿依谢姆·玉苏甫; 曲悦; 谢金洪; 殷丽华

doi:10.3760/cma.j.cn501225-20220506-00172

壳聚糖基创面敷料在创面愈合中的作用及其机制研究进展

doi: 10.3760/cma.j.cn501225-20220506-00172

兰州大学口腔医学院（口腔医院）口腔种植科，兰州　　730000

基金项目:

甘肃省科技计划国际合作专项 18YF1WA116

甘肃省省级引导科技创新发展竞争性项目专项资金 2018ZX-10

兰州市人才创新创业项目 2017-RC-31

详细信息

通讯作者:
殷丽华，Email：yinlh@lzu.edu.cn

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出版历程
- 收稿日期: 2022-05-06

Research advances on the role and mechanism of chitosan-based wound dressing in wound healing

Department of Oral Implant, School/Hospital of Stomatology, Lanzhou University, Lanzhou 730000, China

Funds:

Gansu Provincial Science and Technology Plan International Cooperation Special Project 18YF1WA116

Gansu Provincial Special Fund for Guiding Scientific and Technological Innovation and Development Competitive Project 2018ZX-10

Lanzhou Talent Innovation and Entrepreneurship Project 2017-RC-31

More Information

Corresponding author: Yin Lihua, Email: yinlh@lzu.edu.cn

摘要

摘要: 皮肤是维持机体内环境稳定及抵御外环境有害因素的第1道屏障，且易因外界各种因素受到损伤。当全层皮肤缺损达到一定程度时，皮肤很难进行自我修复，需要创面敷料来促进创面愈合。长期以来，寻找一种能促进创面愈合的理想敷料一直是研究热点。壳聚糖是一种独特的生物多糖聚合物，具有良好的生物相容性、生物降解性、抗菌活性及热稳定性等，在创面敷料的研发与应用方面具有巨大潜力。该文在介绍壳聚糖性质的基础上，综述了壳聚糖基创面敷料在创面愈合中的作用和机制，从壳聚糖的止血作用、抗菌作用、递送作用和促组织再生作用等方面进行了总结，旨在为未来新型壳聚糖基创面敷料的研发提供一定的参考。
- 壳聚糖 /
- 生物敷料 /
- 组织工程 /
- 创面愈合 /
- 作用机制
Abstract: The skin is the first barrier to maintain the stability of internal environment of the body and resist harmful factors of external environment, and is easily damaged because of various external factors. When full-thickness skin defects reach a certain level, it is difficult for the skin to repair itself, so wound dressings are needed to promote wound healing. Seeking an ideal dressing that can promote wound healing has long been a hot research topic. Chitosan is a unique biopolysaccharide polymer with good biocompatibility, biodegradability, antibacterial activity, and thermal stability, which has great potential in the development and application of wound dressings. Based on the introduction of properties of chitosan, this article reviews the role and mechanism of chitosan-based wound dressings in wound healing, and summarizes the hemostatic effect, antibacterial effect, delivery effect, and tissue regeneration promotion effect of chitosan, aiming to provide a certain reference for the research and development of new chitosan-based wound dressings in the future.
- Chitosan /
- Biological dressings /
- Tissue engineering /
- Wound healing /
- Mechanism of action
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参考文献(44)

[1]	FarahaniM, ShafieeA. Wound healing: from passive to smart dressings[J]. Adv Healthc Mater, 2021,10(16):e2100477. DOI: 10.1002/adhm.202100477.
[2]	CostaNN,de Faria LopesL,FerreiraDF,et al.Polymeric films containing pomegranate peel extract based on PVA/starch/PAA blends for use as wound dressing: in vitro analysis and physicochemical evaluation[J].Mater Sci Eng C Mater Biol Appl,2020,109:110643.DOI: 10.1016/j.msec.2020.110643.
[3]	ShariatiniaZ.Pharmaceutical applications of chitosan[J].Adv Colloid Interface Sci,2019,263:131-194.DOI: 10.1016/j.cis.2018.11.008.
[4]	WangWJ,XueCH,MaoXZ.Chitosan: structural modification, biological activity and application[J].Int J Biol Macromol,2020,164:4532-4546.DOI: 10.1016/j.ijbiomac.2020.09.042.
[5]	AzmanaM,MahmoodS,HillesAR,et al.A review on chitosan and chitosan-based bionanocomposites: promising material for combatting global issues and its applications[J].Int J Biol Macromol,2021,185:832-848.DOI: 10.1016/j.ijbiomac.2021.07.023.
[6]	HuZ, ZhangDY, LuST,et al.Chitosan-based composite materials for prospective hemostatic applications[J]. Mar Drugs, 2018,16(8):273. DOI: 10.3390/md16080273.
[7]	LiHB,ChengF,GaoSZ.et al. Preparation, characterization, antibacterial properties, and hemostatic evaluation of ibuprofen-loaded chitosan/gelatin composite films[J]. J Appl Polym Sci,2017,134(42): 45441. DOI: 10.1002/app.45441.
[8]	LanGQ,LuBT,WangTY,et al. Chitosan/gelatin composite sponge is an absorbable surgical hemostatic agent[J].Colloids Surf B Biointerfaces,2015,136:1026-1034.DOI: 10.1016/j.colsurfb.2015.10.039.
[9]	SouzaJM, HenriquesM, TeixeiraP, et al.Comfort and infection control of chitosan-impregnated cotton gauze as wound dressing[J]. Fibers Polym, 2019,20(5):922-932. DOI: 10.1007/s12221-019-9053-2.
[10]	ZhangPJ,ZouBW,LiouYC,et al.The pathogenesis and diagnosis of sepsis post burn injury[J/OL].Burns Trauma,2021,9:tkaa047[2022-05-06]. https://pubmed.ncbi.nlm.nih.gov/33654698/.DOI: 10.1093/burnst/tkaa047.
[11]	MontaserAS,RehanM,El-SenousyWM,et al.Designing strategy for coating cotton gauze fabrics and its application in wound healing[J].Carbohydr Polym,2020,244:116479.DOI: 10.1016/j.carbpol.2020.116479.
[12]	RehanMF, FaridO, IbrahimS, et al.Green and sustainable encapsulation of Guava leaf extracts (Psidium Guajava L.) into alginate/starch microcapsules for multi-functional finish over cotton gauze[J].ACS Sustain Chem Eng, 2019,7:18612-18623. DOI: 10.1021/acssuschemeng.9b04952.
[13]	AshrafiM, BayatM, MortazaviP, et al. Antimicrobial effect of chitosan-silver-copper nanocomposite on Candida albicans[J]. J Nanostructure Chem,2020,10(1): 87-95.DOI: 10.1007/s40097-020-00331-3.
[14]	HwangSM,ChenCY,ChenSS,et al.Chitinous materials inhibit nitric oxide production by activated RAW 264.7 macrophages[J].Biochem Biophys Res Commun,2000,271(1):229-233.DOI: 10.1006/bbrc.2000.2602.
[15]	AhmedS, IkramS.Chitosan based scaffolds and their applications in wound healing[J]. Achiev Life Sci, 2016,10(1): 27-37.DOI: 10.1016/j.als.2016.04.001.
[16]	ZhouC, YangZF, XunXW, et al. De novo strategy with engineering a multifunctional bacterial cellulose-based dressing for rapid healing of infected wounds[J]. Bioact Mater,2021,13:212-222.DOI: 10.1016/j.bioactmat.2021.10.043.
[17]	ZmejkoskiDZ,ZdravkovićNM,TrišićDD,et al. Chronic wound dressings - pathogenic bacteria anti-biofilm treatment with bacterial cellulose-chitosan polymer or bacterial cellulose-chitosan dots composite hydrogels[J].Int J Biol Macromol,2021,191:315-323.DOI: 10.1016/j.ijbiomac.2021.09.118.
[18]	潘超,王晓峰.壳聚糖纳米粒子在药物递送系统中的应用进展[J].实用临床医药杂志,2021,25(4):116-120.DOI: 10.7619/jcmp.20201738.
[19]	ShiYF,XiongZP,LuXF,et al.Novel carboxymethyl chitosan-graphene oxide hybrid particles for drug delivery[J].J Mater Sci Mater Med,2016,27(11):169.DOI: 10.1007/s10856-016-5774-6.
[20]	YuJS, SituB, LuoMH,et al.Carboxymethyl-hexanoyl chitosan nanodroplets for ultrasonic imaging and drug delivery to tumor[J].Curr Pharm Des,2018,24(15):1682-1688.DOI: 10.2174/1381612824666180515122836.
[21]	SinghR,ShitizK,SinghA.Chitin and chitosan: biopolymers for wound management[J].Int Wound J,2017,14(6):1276-1289.DOI: 10.1111/iwj.12797.
[22]	FengZY,WangCD,ParkSJ,et al.Polyamide/chitosan/tetraethyl orthosilicate electrospun nanofibers for a novel and promising drug carrier[J].J Nanosci Nanotechnol,2021,21(12):5912-5919.DOI: 10.1166/jnn.2021.19511.
[23]	KankalaRK, LiuCG,YangDY,et al. Ultrasmall platinum nanoparticles enable deep tumor penetration and synergistic therapeutic abilities through free radical species-assisted catalysis to combat cancer multidrug resistance[J]. Chem Eng J, 2020,383:123138.DOI: 10.1016/j.cej.2019.123138.
[24]	BoyceST,LalleyAL.Tissue engineering of skin and regenerative medicine for wound care[J/OL].Burns Trauma,2018,6:4[2022-05-06]. https://pubmed.ncbi.nlm.nih.gov/30009192/.DOI: 10.1186/s41038-017-0103-y.
[25]	HalimAS, KeongLC, ZainolI, et al. Biocompatibility and biodegradation of chitosan and derivatives[M]//Sarmento B, Neves JD. Chitosan-based systems for biopharma-ceuticals: delivery, targeting and polymer therapeutics. Hoboken: Wiley, 2012:57-73.
[26]	王征,刘万顺,韩宝芹,等.不同分子量羧甲基壳聚糖的制备及其对皮肤成纤维细胞和角质形成细胞生长的影响[J].生物医学工程学杂志,2007,24(2):340-344.DOI: 10.3321/j.issn:1001-5515.2007.02.022.
[27]	ChenXG,WangZ,LiuWS,et al.The effect of carboxymethyl-chitosan on proliferation and collagen secretion of normal and keloid skin fibroblasts[J].Biomaterials,2002,23(23):4609-4614.DOI: 10.1016/s0142-9612(02)00207-7.
[28]	XuXW,GuSC,HuangX,et al.The role of macrophages in the formation of hypertrophic scars and keloids[J/OL].Burns Trauma,2020,8:tkaa006[2022-05-06]. https://pubmed.ncbi.nlm.nih.gov/32341919/.DOI: 10.1093/burnst/tkaa006.
[29]	OkamotoY,WatanabeM,MiyatakeK,et al.Effects of chitin/chitosan and their oligomers/monomers on migrations of fibroblasts and vascular endothelium[J].Biomaterials,2002,23(9):1975-1979.DOI: 10.1016/s0142-9612(01)00324-6.
[30]	Ahmed Saeed Al-JapairaiK, MahmoodS, Hamed AlmurisiS, et al.Current trends in polymer microneedle for transdermal drug delivery[J].Int J Pharm,2020,587:119673.DOI: 10.1016/j.ijpharm.2020.119673.
[31]	OkamotoY, KawakamiK, MiyatakeK, et al.Analgesic effects of chitin and chitosan[J]. Carbohydr Polym,2002,49(3):249-252.DOI: 10.1016/S0144-8617(01)00316-2.
[32]	KlaypraditW, HuangYW. Fish oil encapsulation with chitosan using ultrasonic atomizer[J].LWT-Food Sci Technol, 2008, 41(6):1133-1139.DOI: 10.1016/j.lwt.2007.06.014.
[33]	UenoH,NakamuraF,MurakamiM,et al.Evaluation effects of chitosan for the extracellular matrix production by fibroblasts and the growth factors production by macrophages[J].Biomaterials,2001,22(15):2125-2130.DOI: 10.1016/s0142-9612(00)00401-4.
[34]	RongioneAJ,KusskeAM,AshleySW,et al.Interleukin-10 prevents early cytokine release in severe intraabdominal infection and sepsis[J].J Surg Res,1997,70(2):107-112.DOI: 10.1006/jsre.1997.5071.
[35]	LiechtyKW,KimHB,AdzickNS,et al.Fetal wound repair results in scar formation in interleukin-10-deficient mice in a syngeneic murine model of scarless fetal wound repair[J].J Pediatr Surg,2000,35(6):866-872; discussion 872-873.DOI: 10.1053/jpsu.2000.6868.
[36]	FengT, DuYM, LiJ, et al. Antioxidant activity of half N-acetylated watersoluble chitosan in vitro[J]. Eur Food Res Technol, 2007,225(1):133-138.DOI: 10.1007/s00217-006-0391-0.
[37]	陈跃华,徐俊,徐兰举,等.水凝胶敷料对糖尿病足创面的促愈合作用研究进展[J].中华烧伤与创面修复杂志,2022,38(1):95-98.DOI: 10.3760/cma.j.cn501120-20200827-00393.
[38]	WangHH,LiuY,CaiK,et al.Antibacterial polysaccharide-based hydrogel dressing containing plant essential oil for burn wound healing[J/OL].Burns Trauma,2021,9:tkab041[2022-05-06]. https://pubmed.ncbi.nlm.nih.gov/34988231/.DOI: 10.1093/burnst/tkab041.
[39]	MiguelSP,MoreiraAF,CorreiaIJ.Chitosan based-asymmetric membranes for wound healing: a review[J].Int J Biol Macromol,2019,127:460-475.DOI: 10.1016/j.ijbiomac.2019.01.072.
[40]	LiuH,WangCY,LiC,et al.A functional chitosan-based hydrogel as a wound dressing and drug delivery system in the treatment of wound healing[J].RSC Adv,2018,8(14):7533-7549.DOI: 10.1039/c7ra13510f.
[41]	LiX,ChenS,LiJE,et al.Chemical composition and antioxidant activities of polysaccharides from Yingshan Cloud Mist Tea[J].Oxid Med Cell Longev,2019,2019:1915967.DOI: 10.1155/2019/1915967.
[42]	QuJ,ZhaoX,LiangYP,et al.Antibacterial adhesive injectable hydrogels with rapid self-healing, extensibility and compressibility as wound dressing for joints skin wound healing[J].Biomaterials,2018,183:185-199.DOI: 10.1016/j.biomaterials.2018.08.044.
[43]	LiT, NaR, YuP, et al. Effects of dietary supplementation of chitosan on immune and antioxidative function in beef cattle[J]. Czech J Anim Sci, 2015,60(1):38-44.DOI: 10.17221/7910-CJAS.
[44]	刘江,刘毅.壳聚糖纳米纤维创面敷料的研究进展[J].中华烧伤杂志,2020,36(7):627-630.DOI: 10.3760/cma.j.cn501120-20190628-00286.