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核转录因子红系2相关因子2在创面愈合中的作用研究进展

郭佳 张军霞

郭佳, 张军霞. 核转录因子红系2相关因子2在创面愈合中的作用研究进展[J]. 中华烧伤与创面修复杂志, 2023, 39(1): 91-95. DOI: 10.3760/cma.j.cn501225-20220531-00209.
引用本文: 郭佳, 张军霞. 核转录因子红系2相关因子2在创面愈合中的作用研究进展[J]. 中华烧伤与创面修复杂志, 2023, 39(1): 91-95. DOI: 10.3760/cma.j.cn501225-20220531-00209.
Guo J,Zhang JX.Research advances on the role of nuclear factor-erythroid 2-related factor 2 in wound healing[J].Chin J Burns Wounds,2023,39(1):91-95.DOI: 10.3760/cma.j.cn501225-20220531-00209.
Citation: Guo J,Zhang JX.Research advances on the role of nuclear factor-erythroid 2-related factor 2 in wound healing[J].Chin J Burns Wounds,2023,39(1):91-95.DOI: 10.3760/cma.j.cn501225-20220531-00209.

核转录因子红系2相关因子2在创面愈合中的作用研究进展

doi: 10.3760/cma.j.cn501225-20220531-00209
基金项目: 

湖北省自然科学基金 2020CFB574

湖北省卫生健康科研基金重点支撑项目 WJ2021Z010

详细信息
    通讯作者:

    张军霞,Email:zhangjx023@163.com

Research advances on the role of nuclear factor-erythroid 2-related factor 2 in wound healing

Funds: 

Natural Science Foundation of Hubei Province of China 2020CFB574

Key Supporting Projects of Hubei Provincial Health Research Fund WJ2021Z010

More Information
  • 摘要: 创面愈合是机体常见的病理生理过程之一。如何改善创面愈合条件,使创面快速愈合,一直是研究的热点。氧化应激是影响创面愈合的重要因素之一。核转录因子红系2相关因子2(Nrf2)是一种经典的抗氧化应激因子,也是极具潜力的促创面愈合因子。Nrf2的激活可以调控下游的抗氧化应激元件,发挥抗细胞凋亡、维持细胞稳态的作用,从而改善创面的愈合环境,促进创面的修复。该文概述了Nrf2常见的激动剂及抑制剂,并综述了Nrf2促进糖尿病溃疡、辐射损伤、缺血再灌注损害等皮肤创面愈合的作用。

     

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  • 收稿日期:  2022-05-31

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