Visual analysis of the current research status and development of burn-related coagulation dysfunction
-
摘要:
目的 对烧伤相关凝血功能障碍的文献进行可视化分析，探讨国内外烧伤相关凝血功能障碍的研究现状、演进过程、热点主题以及未来研究趋势。 方法 采用文献计量学方法进行分析。检索《Web of Science》和《中国知网》数据库1950年1月1日—2022年5月1日发表的符合入选标准的烧伤相关凝血功能障碍的文献，进行发文量分析。同前检索《Web of Science》数据库核心合集和《中国知网》数据库中烧伤相关凝血功能障碍的文献，采用CiteSpace5.8.R3软件行关键词共现分析、聚类分析及文献共被引分析。 结果 从《Web of Science》和《中国知网》数据库分别检索到501、235篇文献。国内外分别于1975、1950年开始出现烧伤相关凝血功能障碍的文献，随后相关文献逐渐增加。《中国知网》数据库235篇文献中烧伤、凝血功能、血小板等关键词出现频次和中心性较高，《Web of Science》数据库核心合集340篇文献中burn、coagulation、deep vein thrombosis等关键词出现频次和中心性较高。《中国知网》数据库中，突现强度排前6的关键词为烧伤患者、临床意义、烧伤面积、凝血功能、预后、血小板，且前3个关键词为早期突现关键词；《Web of Science》数据库核心合集中，突现强度排前列的关键词disseminated intravascular coagulation、pulmonary embolism为早期突现关键词。《中国知网》数据库中具有代表性的聚类标签是#0烧伤、#1休克、#2并发症等，《Web of Science》数据库核心合集中具有代表性的聚类标签是#0 risk、#1 surgical patient、#2 sepsis等。在《中国知网》数据库和《Web of Science》数据库核心合集中早期研究更关注烧伤相关凝血功能障碍的存在本身，而后期研究更关注烧伤相关凝血功能障碍与炎症、免疫、凝血全貌、创面的关系。2010年及以后《Web of Science》数据库核心合集中出现了较多核心被引文献，静脉血栓栓塞防治是近年最受关注的研究方向，烧伤相关凝血功能障碍的诊断方法的优化和标准化以及对其整体机制的研究将是未来的主要研究方向。 结论 国内外烧伤相关凝血功能障碍的研究热点和演进过程既有相似性也有差异性，目前的研究热点在于凝血与炎症、免疫等的关系。随着研究的深入，烧伤相关凝血功能障碍的诊断方法的优化和标准化以及对其整体机制的研究将是未来的主要研究方向。 Abstract:Objective To conduct a visual analysis of the literature on burn-related coagulation dysfunction and to explore the current research status, evolution process, hot topics, and future research trends in burn-related coagulation dysfunction at home and abroad. Methods The bibliometrics method was used. The literature on burn-related coagulation dysfunction which were published in Web of Science and China National Knowledge Internet databases from January 1, 1950 to May 1, 2022, and met the inclusion criteria were retrieved for publication volume analysis. The literature on burn-related coagulation dysfunction were retrieved as above in the core collection of Web of Science and China National Knowledge Internet databases, and CiteSpace 5.8.R3 software was used to perform co-occurrence analysis, cluster analysis, and literature co-citation analysis of key words. Results A total of 501 and 235 literature on burn-related coagulation dysfunction were retrieved from Web of Science database and China National Knowledge Internet database, respectively. The literature on burn-related coagulation dysfunction emerged from 1975 and 1950, respectively, in China and abroad, which were gradually increased later. The frequency and centrality of Chinese key words such as 烧伤, 凝血功能, 血小板 were high in 235 literature in China National Knowledge Internet database, and the frequency and centrality of key words such as burn, coagulation, and deep vein thrombosis were high in 340 literature in the core collection of Web of Science database. In China National Knowledge Internet database, the top 6 Chinese key words in terms of burst intensity were 烧伤患者, 临床意义, 烧伤面积, 凝血功能, 预后, 血小板, and the first 3 among which were burst key words in the early stage; and in the core collection of Web of Science database, the key words with higher burst intensity were disseminated intravascular coagulation and pulmonary embolism, which were the burst key words in the early stage. The representative clustering labels in China National Knowledge Internet database were #0 烧伤, #1 休克, and #2 并发症, etc., and the representative clustering labels in the core collection of Web of Science database were #0 risk, #1 surgical patient, and #2 sepsis. Early researches in China National Knowledge Internet database and the core collection of Web of Science database focused on the presence of burn-related coagulation dysfunction itself, while the late researches focused on the relationship between burn-related coagulation dysfunction and inflammation, immunity, coagulation in general, and wounds. From 2010 onwards, there were a large number of core cited literature in the core collection of Web of Science database, and the prevention and treatment of vein thromboembolism was the most popular research direction in recent years. The researches on optimization and standardization of diagnostic methods and the overall mechanism of burn-related coagulation dysfunction would be the main research directions in the future. Conclusions The research hotspots and evolution processes of burn-related coagulation dysfunction at home and abroad have both similarities and differences, and the current research hotspot is the relationship between coagulation and inflammation, immunity. With researches increasingly deepening, the researches on optimization and standardization of diagnostic methods and the overall mechanism of burn-related coagulation dysfunction will be the main research directions in the future. -
Key words:
- Burns /
- Bibliometrics /
- Cluster analysis /
- Coagulation dysfunction /
- Visual analysis
-
参考文献
(37) [1] SmolleC,Cambiaso-DanielJ,ForbesAA,et al.Recent trends in burn epidemiology worldwide: a systematic review[J].Burns,2017,43(2):249-257.DOI: 10.1016/j.burns.2016.08.013. [2] 夏照帆,朱峰.重视危重烧伤凝血障碍的诊治[J].医学研究生学报,2018,31(8):785-789.DOI: 10.16571/j.cnki.1008-8199.2018.08.001. [3] LuRP,NiA,LinFC,et al.Major burn injury is not associated with acute traumatic coagulopathy[J].J Trauma Acute Care Surg,2013,74(6):1474-1479.DOI: 10.1097/TA.0b013e3182923193. [4] ChenC. Searching for intellectual turning points: progressive knowledge domain visualization[J]. Proc Natl Acad Sci U S A, 2004, 101Suppl 1(Suppl 1): 5303-5310. DOI: 10.1073/pnas.0307513100. [5] 陈悦,陈超美,刘则渊,等.CiteSpace知识图谱的方法论功能[J].科学学研究,2015,33(2):242-253.DOI: 10.3969/j.issn.1003-2053.2015.02.009. [6] GeorgievaSA.Blood coagulation in burns[J].Klin Med (Mosk),1950,28(5):91-92. [7] MonteilR,ReynierC,VigneJ,et al.Study of blood platelet variations in coagulation disorders in burned patients[J].Hemostase,1963,3:239-249. [8] 张文玉. 肝素治疗人体大面积烧伤 [J]. 国际外科学杂志, 1975(1): 29-30. [9] GabilondoJ.Coagulation and platelet changes after thermal injury in man[J].Burns Incl Therm Inj,1982,8(4):302.DOI: 10.1016/0305-4179(82)90026-2. [10] CirinoG,NapoliC,BucciM,et al.Inflammation-coagulation network: are serine protease receptors the knot?[J].Trends Pharmacol Sci,2000,21(5):170-172.DOI: 10.1016/s0165-6147(00)01469-3. [11] RezendeSM,SimmondsRE,LaneDA.Coagulation, inflammation, and apoptosis: different roles for protein S and the protein S-C4b binding protein complex[J].Blood,2004,103(4):1192-1201.DOI: 10.1182/blood-2003-05-1551. [12] MitraB,WasiakJ,CameronPA,et al.Early coagulopathy of major burns[J].Injury,2013,44(1):40-43.DOI: 10.1016/j.injury.2012.05.010. [13] ZuckermanL,CapriniJA,LippV,et al.Disseminated intravascular multiple systems activation (DIMSA) following thermal injury[J].J Trauma,1978,18(6):432-439.DOI: 10.1097/00005373-197806000-00008. [14] CurreriPW,WilterdinkME,BaxterCR.Coagulation dynamics following thermal injury: effect of heparin and protamine sulfate[J].Ann Surg,1975,181(2):161-163.DOI: 10.1097/00000658-197502000-00006. [15] BarretJP,GomezPA.Disseminated intravascular coagulation: a rare entity in burn injury[J].Burns,2005,31(3):354-357.DOI: 10.1016/j.burns.2004.11.006. [16] LavrentievaA,KontakiotisT,BitzaniM,et al.Early coagulation disorders after severe burn injury: impact on mortality[J].Intensive Care Med,2008,34(4):700-706.DOI: 10.1007/s00134-007-0976-5. [17] 赵永健,门剑龙,刘群.焦痂切除对大面积烧伤早期凝血、抗凝血系统功能状态的影响[J].中华急诊医学杂志,2003,12(10):695-696.DOI: 10.3760/j.issn:1671-0282.2003.10.018. [18] 曹卫红,柴家科,杨红明,等.大剂量乌司他丁对大面积烧伤患者凝血功能的影响及意义[J].感染、炎症、修复,2005,6(3):162-164.DOI: 10.3969/j.issn.1672-8521.2005.03.010. [19] MarckRE,van der BijlI,KorstenH,et al.Activation, function and content of platelets in burn patients[J].Platelets,2019,30(3):396-402.DOI: 10.1080/09537104.2018.1448379. [20] WiegeleM,SchadenE,KochS,et al.Thrombin generation in patients with severe thermal injury[J].Burns,2019,45(1):54-62.DOI: 10.1016/j.burns.2018.09.020. [21] GengK,LiuY,YangY,et al.Incidence and prognostic value of acute coagulopathy after extensive severe burns[J].J Burn Care Res,2020,41(3):544-549.DOI: 10.1093/jbcr/irz178. [22] 马琪敏,刘晓彬,伍国胜,等.特重度成年烧伤患者休克期凝血特征及其预警价值的回顾性队列研究[J].中华烧伤杂志,2021,37(2):150-156.DOI: 10.3760/cma.j.cn501120-20200907-00402. [23] KaitaY,NishimuraH,TanakaY,et al.Effect of acute coagulopathy before fluid administration in mortality for burned patients[J].Burns,2021,47(4):805-811.DOI: 10.1016/j.burns.2020.10.011. [24] WinearlsJ,ReadeM,MilesH,et al.Targeted coagulation management in severe trauma: the controversies and the evidence[J].Anesth Analg,2016,123(4):910-924.DOI: 10.1213/ANE.0000000000001516. [25] PratNJ,HerzigMC,KreyerS,et al.Platelet and coagulation function before and after burn and smoke inhalation injury in sheep[J].J Trauma Acute Care Surg,2017,83(1 Suppl 1):S59-65.DOI: 10.1097/TA.0000000000001472. [26] MiduraEF,KuetheJW,RiceTC,et al.Impact of platelets and platelet-derived microparticles on hypercoagulability following burn injury[J].Shock,2016,45(1):82-87.DOI: 10.1097/SHK.0000000000000460. [27] MeizosoJP,RayJJ,AllenCJ,et al.Hypercoagulability and venous thromboembolism in burn patients[J].Semin Thromb Hemost,2015,41(1):43-48.DOI: 10.1055/s-0034-1398380. [28] AugerC,SamadiO,JeschkeMG.The biochemical alterations underlying post-burn hypermetabolism[J].Biochim Biophys Acta Mol Basis Dis,2017,1863(10 Pt B):2633-2644.DOI: 10.1016/j.bbadis.2017.02.019. [29] GeertsWH,BergqvistD,PineoGF,et al.Prevention of venous thromboembolism: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition)[J].Chest,2008,133(6 Suppl):S381-453.DOI: 10.1378/chest.08-0656. [30] BallRL,KeylounJW,Brummel-ZiedinsK,et al.Burn-induced coagulopathies: a comprehensive review[J].Shock,2020,54(2):154-167.DOI: 10.1097/SHK.0000000000001484. [31] JeschkeMG,van BaarME,ChoudhryMA,et al.Burn injury[J].Nat Rev Dis Primers,2020,6(1):11.DOI: 10.1038/s41572-020-0145-5. [32] YounanD,GriffinR,ThompsonM,et al.Early coagulopathy is associated with increased incidence of ventilator-associated events among burn patients[J].Shock,2017,47(1):107-110.DOI: 10.1097/SHK.0000000000000738. [33] LiuJ,LiuY,LiuS,et al.Hypocoagulation induced by broad-spectrum antibiotics in extensive burn patients[J/OL].Burns Trauma,2019,7:13[2022-06-16]. https://pubmed.ncbi.nlm.nih.gov/31058197/.DOI: 10.1186/s41038-019-0150-7. [34] 蒋航 重度及特重度烧伤患者血小板、TEG参数及凝血指标的动态变化特征与相关性分析 遵义 贵州医科大学 2021 蒋航. 重度及特重度烧伤患者血小板、TEG参数及凝血指标的动态变化特征与相关性分析[D]. 遵义:贵州医科大学,2021.
[35] 肖昆,赵斐,廖新成,等.早期纠正凝血功能障碍降低大面积烧伤成年患者28 d病死率[J].中南大学学报(医学版),2021,46(8):851-857.DOI: 10.11817/j.issn.1672-7347.2021.190817. [36] 刘晓彬 MIMIC数据库脓毒症早期凝血指标预警价值及深度烧伤数据挖掘方法研究 上海 海军军医大学 2021 刘晓彬. MIMIC数据库脓毒症早期凝血指标预警价值及深度烧伤数据挖掘方法研究 [D]. 上海:海军军医大学,2021.
[37] GlasGJ, LeviM, SchultzMJ. Coagulopathy and its management in patients with severe burns [J]. J Thromb Haemost, 2016, 14(5): 865-874. DOI: 10.1111/jth.13283. -
2 1950—2022年《中国知网》数据库中235篇和《Web of Science》数据库核心合集中340篇烧伤相关凝血功能障碍的文献的关键词共现图。2A.《中国知网》数据库；2B.《Web of Science》数据库核心合集
注：紫色的圆环代表该关键词具有高中心性；节点大小代表关键词的出现频次，节点越大，表示该关键词出现的频次越高；连线代表关键词的联系，连线越多，表示关键词在同一篇文献中出现的次数越多；burn为烧伤，coagulation为凝血，deep vein thrombosis为深静脉血栓，thrombosis为血栓形成，disseminated intravascular coagulation为弥散性血管内凝血，complication为并发症
3 1950—2022年《中国知网》数据库中235篇和《Web of Science》数据库核心合集中340篇烧伤相关凝血功能障碍的文献的关键词聚类图。3A.《中国知网》数据库；3B.《Web of Science》数据库核心合集
注：图3B中risk为风险，surgical patient为手术患者，sepsis为脓毒症，activation为激活，antifactor Ⅹa level为凝血因子Ⅹa抗体水平，expression为表达，deep vein thrombosis为深静脉血栓，multiorgan failure为多器官衰竭，thromboxane为血栓素，arterial thrombosis为动脉血栓
4 1950—2022年《中国知网》数据库中235篇和《Web of Science》数据库核心合集中340篇烧伤相关凝血功能障碍的文献的关键词聚类时间线图。4A.《中国知网》数据库；4B.《Web of Science》数据库核心合集
注：节点大小代表关键词的出现频次，节点越大，表示该关键词出现的频次越高；连线代表关键词的联系，连线越多，表示关键词在同一篇文献中出现的次数越多；内部红圈代表高突现强度；紫色的圆环代表高中心性；图3B中risk为风险，surgical patient为手术患者，sepsis为脓毒症，activation为激活，antifactor Ⅹa level为凝血因子Ⅹa抗体水平，expression为表达，deep vein thrombosis为深静脉血栓，multiorgan failure为多器官衰竭，thromboxane为血栓素，arterial thrombosis为动脉血栓
5 1950—2022年《Web of Science》数据库核心合集中340篇烧伤相关凝血功能障碍的文献共被引图
注：2篇或多篇文献同时被1篇及以上文献引用，则这2篇或多篇文献构成共被引关系；括号中为文献发表年份，网络中的连线代表文献之间的共引关系，节点越大代表该文献被引用得越多，即为该领域的重要文献
表1 1950—2022年《中国知网》数据库中235篇烧伤相关凝血功能障碍的文献中突现强度排前10的关键词的突现情况
关键词 突现强度 开始年份 结束年份 烧伤患者 2.92 1980 2003 临床意义 2.68 1980 1991 烧伤面积 3.32 1985 2009 凝血酶 2.30 1988 2001 血栓 2.26 1997 2001 血小板 3.10 1998 1999 护理 2.54 2012 2019 凝血功能 4.09 2015 2020 乌司他丁 2.58 2015 2019 预后 2.75 2016 2018 
下载: 导出CSV
表2 1950—2022年《Web of Science》数据库核心合集中340篇烧伤相关凝血功能障碍的文献中突现强度排前10的关键词的突现情况
关键词 突现强度 开始年份 结束年份 disseminated intravascular coagulation（弥散性血管内凝血） 2.49 1994 2000 pulmonary embolism（肺栓塞） 2.60 2002 2009 burn patient（烧伤患者） 3.57 2004 2016 prevention（预防） 2.73 2011 2012 risk（风险） 3.32 2013 2019 mortality（致死率） 3.19 2013 2022 coagulation（凝血功能） 3.56 2016 2022 hypercoagulation（高凝） 2.98 2016 2017 sepsis（脓毒症） 4.23 2017 2018 trauma（创伤） 2.77 2020 2022
下载: 导出CSV
表3 1950—2022年《Web of Science》数据库核心合集中烧伤相关凝血功能障碍的核心被引文献中心性和突现强度情况
DOI 中心性 突现强度 开始年份 结束年份 10.1111/jth.13283 0.030 4.96 2017 2022 10.1055/s-0034-1398380 0.078 4.49 2016 2020 10.1378/chest.08-0656 0.062 7.84 2009 2013 10.1097/BCR.0b013e318204b346 0.058 4.53 2011 2016 10.1097/BCR.0b013e31827819a1 0.002 4.65 2015 2017 10.1097/TA.0b013e3182984911 0.012 4.65 2015 2017 10.1016/j.burns.2013.02.010 0.002 5.72 2016 2018 10.1016/j.injury.2012.05.010 0.002 4.57 2016 2018
下载: 导出CSV
-
图(6) / 表(3)
计量
- 文章访问数: 227
- HTML全文浏览量: 86
- PDF下载量: 34
- 被引次数: 0
