烧伤相关凝血功能障碍研究现状与发展的可视化分析

马琪敏; 王玉松; 侯文佳; 刘晓彬; 沈拓; 朱峰

doi:10.3760/cma.j.cn501225-20220616-00237

烧伤相关凝血功能障碍研究现状与发展的可视化分析

doi: 10.3760/cma.j.cn501225-20220616-00237

海军军医大学第一附属医院烧创伤ICU，上海　　200433

基金项目:

国家重点研发计划 2019YFA0110601

上海市急危重症临床医学研究中心项目 21MC1930400

详细信息

通讯作者:
朱峰，Email：alexzhujunchi@hotmail.com

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出版历程
- 收稿日期: 2022-06-16

Visual analysis of the current research status and development of burn-related coagulation dysfunction

Intensive Care Unit of Burns and Trauma, the First Affiliated Hospital, Naval Medical University, Shanghai 200433, China

Funds:

National Key R & D Program of China 2019YFA0110601

Project of Shanghai Acute and Critical Care Clinical Medicine Research Center 21MC1930400

More Information

Corresponding author: Zhu Feng, Email: alexzhujunchi@hotmail.com

摘要

摘要: 目的对烧伤相关凝血功能障碍的文献进行可视化分析，探讨国内外烧伤相关凝血功能障碍的研究现状、演进过程、热点主题以及未来研究趋势。方法采用文献计量学方法进行分析。检索《Web of Science》和《中国知网》数据库1950年1月1日—2022年5月1日发表的符合入选标准的烧伤相关凝血功能障碍的文献，进行发文量分析。同前检索《Web of Science》数据库核心合集和《中国知网》数据库中烧伤相关凝血功能障碍的文献，采用CiteSpace5.8.R3软件行关键词共现分析、聚类分析及文献共被引分析。结果从《Web of Science》和《中国知网》数据库分别检索到501、235篇文献。国内外分别于1975、1950年开始出现烧伤相关凝血功能障碍的文献，随后相关文献逐渐增加。《中国知网》数据库235篇文献中烧伤、凝血功能、血小板等关键词出现频次和中心性较高，《Web of Science》数据库核心合集340篇文献中burn、coagulation、deep vein thrombosis等关键词出现频次和中心性较高。《中国知网》数据库中，突现强度排前6的关键词为烧伤患者、临床意义、烧伤面积、凝血功能、预后、血小板，且前3个关键词为早期突现关键词；《Web of Science》数据库核心合集中，突现强度排前列的关键词disseminated intravascular coagulation、pulmonary embolism为早期突现关键词。《中国知网》数据库中具有代表性的聚类标签是#0烧伤、#1休克、#2并发症等，《Web of Science》数据库核心合集中具有代表性的聚类标签是#0 risk、#1 surgical patient、#2 sepsis等。在《中国知网》数据库和《Web of Science》数据库核心合集中早期研究更关注烧伤相关凝血功能障碍的存在本身，而后期研究更关注烧伤相关凝血功能障碍与炎症、免疫、凝血全貌、创面的关系。2010年及以后《Web of Science》数据库核心合集中出现了较多核心被引文献，静脉血栓栓塞防治是近年最受关注的研究方向，烧伤相关凝血功能障碍的诊断方法的优化和标准化以及对其整体机制的研究将是未来的主要研究方向。结论国内外烧伤相关凝血功能障碍的研究热点和演进过程既有相似性也有差异性，目前的研究热点在于凝血与炎症、免疫等的关系。随着研究的深入，烧伤相关凝血功能障碍的诊断方法的优化和标准化以及对其整体机制的研究将是未来的主要研究方向。
- 烧伤 /
- 文献计量学 /
- 聚类分析 /
- 凝血功能障碍 /
- 可视化分析
Abstract: Objective To conduct a visual analysis of the literature on burn-related coagulation dysfunction and to explore the current research status, evolution process, hot topics, and future research trends in burn-related coagulation dysfunction at home and abroad. Methods The bibliometrics method was used. The literature on burn-related coagulation dysfunction which were published in Web of Science and China National Knowledge Internet databases from January 1, 1950 to May 1, 2022, and met the inclusion criteria were retrieved for publication volume analysis. The literature on burn-related coagulation dysfunction were retrieved as above in the core collection of Web of Science and China National Knowledge Internet databases, and CiteSpace 5.8.R3 software was used to perform co-occurrence analysis, cluster analysis, and literature co-citation analysis of key words. Results A total of 501 and 235 literature on burn-related coagulation dysfunction were retrieved from Web of Science database and China National Knowledge Internet database, respectively. The literature on burn-related coagulation dysfunction emerged from 1975 and 1950, respectively, in China and abroad, which were gradually increased later. The frequency and centrality of Chinese key words such as 烧伤, 凝血功能, 血小板 were high in 235 literature in China National Knowledge Internet database, and the frequency and centrality of key words such as burn, coagulation, and deep vein thrombosis were high in 340 literature in the core collection of Web of Science database. In China National Knowledge Internet database, the top 6 Chinese key words in terms of burst intensity were 烧伤患者, 临床意义, 烧伤面积, 凝血功能, 预后, 血小板, and the first 3 among which were burst key words in the early stage; and in the core collection of Web of Science database, the key words with higher burst intensity were disseminated intravascular coagulation and pulmonary embolism, which were the burst key words in the early stage. The representative clustering labels in China National Knowledge Internet database were #0 烧伤, #1 休克, and #2 并发症, etc., and the representative clustering labels in the core collection of Web of Science database were #0 risk, #1 surgical patient, and #2 sepsis. Early researches in China National Knowledge Internet database and the core collection of Web of Science database focused on the presence of burn-related coagulation dysfunction itself, while the late researches focused on the relationship between burn-related coagulation dysfunction and inflammation, immunity, coagulation in general, and wounds. From 2010 onwards, there were a large number of core cited literature in the core collection of Web of Science database, and the prevention and treatment of vein thromboembolism was the most popular research direction in recent years. The researches on optimization and standardization of diagnostic methods and the overall mechanism of burn-related coagulation dysfunction would be the main research directions in the future. Conclusions The research hotspots and evolution processes of burn-related coagulation dysfunction at home and abroad have both similarities and differences, and the current research hotspot is the relationship between coagulation and inflammation, immunity. With researches increasingly deepening, the researches on optimization and standardization of diagnostic methods and the overall mechanism of burn-related coagulation dysfunction will be the main research directions in the future.
- Burns /
- Bibliometrics /
- Cluster analysis /
- Coagulation dysfunction /
- Visual analysis
马琪敏：文献整理与管理，可视化分析，论文撰写；王玉松：文献整理与管理，可视化分析；侯文佳：论文起草，论文修改；刘晓彬：论文起草，可视化分析；沈拓：调整可视化分析；朱峰：研究方案设计，研究课题监管与指导，论文审阅

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1 1950—2022 年《中国知网》和《Web of Science》数据库中与烧伤相关凝血功能障碍相关的发文量情况

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2 1950—2022年《中国知网》数据库中235篇和《Web of Science》数据库核心合集中340篇烧伤相关凝血功能障碍的文献的关键词共现图。2A.《中国知网》数据库；2B.《Web of Science》数据库核心合集

注：紫色的圆环代表该关键词具有高中心性；节点大小代表关键词的出现频次，节点越大，表示该关键词出现的频次越高；连线代表关键词的联系，连线越多，表示关键词在同一篇文献中出现的次数越多；burn为烧伤，coagulation为凝血，deep vein thrombosis为深静脉血栓，thrombosis为血栓形成，disseminated intravascular coagulation为弥散性血管内凝血，complication为并发症

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3 1950—2022年《中国知网》数据库中235篇和《Web of Science》数据库核心合集中340篇烧伤相关凝血功能障碍的文献的关键词聚类图。3A.《中国知网》数据库；3B.《Web of Science》数据库核心合集

注：图3B中risk为风险，surgical patient为手术患者，sepsis为脓毒症，activation为激活，antifactor Ⅹa level为凝血因子Ⅹa抗体水平，expression为表达，deep vein thrombosis为深静脉血栓，multiorgan failure为多器官衰竭，thromboxane为血栓素，arterial thrombosis为动脉血栓

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4 1950—2022年《中国知网》数据库中235篇和《Web of Science》数据库核心合集中340篇烧伤相关凝血功能障碍的文献的关键词聚类时间线图。4A.《中国知网》数据库；4B.《Web of Science》数据库核心合集

注：节点大小代表关键词的出现频次，节点越大，表示该关键词出现的频次越高；连线代表关键词的联系，连线越多，表示关键词在同一篇文献中出现的次数越多；内部红圈代表高突现强度；紫色的圆环代表高中心性；图3B中risk为风险，surgical patient为手术患者，sepsis为脓毒症，activation为激活，antifactor Ⅹa level为凝血因子Ⅹa抗体水平，expression为表达，deep vein thrombosis为深静脉血栓，multiorgan failure为多器官衰竭，thromboxane为血栓素，arterial thrombosis为动脉血栓

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5 1950—2022年《Web of Science》数据库核心合集中340篇烧伤相关凝血功能障碍的文献共被引图

注：2篇或多篇文献同时被1篇及以上文献引用，则这2篇或多篇文献构成共被引关系；括号中为文献发表年份，网络中的连线代表文献之间的共引关系，节点越大代表该文献被引用得越多，即为该领域的重要文献

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表1 1950—2022年《中国知网》数据库中235篇烧伤相关凝血功能障碍的文献中突现强度排前10的关键词的突现情况

关键词	突现强度	开始年份	结束年份
烧伤患者	2.92	1980	2003
临床意义	2.68	1980	1991
烧伤面积	3.32	1985	2009
凝血酶	2.30	1988	2001
血栓	2.26	1997	2001
血小板	3.10	1998	1999
护理	2.54	2012	2019
凝血功能	4.09	2015	2020
乌司他丁	2.58	2015	2019
预后	2.75	2016	2018

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表2 1950—2022年《Web of Science》数据库核心合集中340篇烧伤相关凝血功能障碍的文献中突现强度排前10的关键词的突现情况

关键词	突现强度	开始年份	结束年份
disseminated intravascular coagulation（弥散性血管内凝血）	2.49	1994	2000
pulmonary embolism（肺栓塞）	2.60	2002	2009
burn patient（烧伤患者）	3.57	2004	2016
prevention（预防）	2.73	2011	2012
risk（风险）	3.32	2013	2019
mortality（致死率）	3.19	2013	2022
coagulation（凝血功能）	3.56	2016	2022
hypercoagulation（高凝）	2.98	2016	2017
sepsis（脓毒症）	4.23	2017	2018
trauma（创伤）	2.77	2020	2022

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表3 1950—2022年《Web of Science》数据库核心合集中烧伤相关凝血功能障碍的核心被引文献中心性和突现强度情况

DOI	中心性	突现强度	开始年份	结束年份
10.1111/jth.13283	0.030	4.96	2017	2022
10.1055/s-0034-1398380	0.078	4.49	2016	2020
10.1378/chest.08-0656	0.062	7.84	2009	2013
10.1097/BCR.0b013e318204b346	0.058	4.53	2011	2016
10.1097/BCR.0b013e31827819a1	0.002	4.65	2015	2017
10.1097/TA.0b013e3182984911	0.012	4.65	2015	2017
10.1016/j.burns.2013.02.010	0.002	5.72	2016	2018
10.1016/j.injury.2012.05.010	0.002	4.57	2016	2018

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