生物材料促进创面血管化的研究进展

陈良龙; 于盛祥; 马军; 高艳彬; 杨磊

doi:10.3760/cma.j.cn501225-20220626-00261

生物材料促进创面血管化的研究进展

doi: 10.3760/cma.j.cn501225-20220626-00261

南方医科大学南方医院烧伤科，广州　　510515

基金项目:

广东省自然科学基金 2020A151501108

广东省重点领域研发计划项目 2020B1111150001

广东省省级科技计划项目 2018KJYZ005

西藏自治区自然科学基金 XZ2017ZR-ZY021

详细信息

通讯作者:
杨磊，Email：yuanyang@smu.edu.cn

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- 被引次数: 0
出版历程
- 收稿日期: 2022-06-26

Research progress of biomaterials in promoting wound vascularization

Department of Burns, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China

Funds:

Guangdong Natural Science Foundation of China 2020A151501108

Key Field Research and Development Program of Guangdong Province of China 2020B1111150001

Provincial Science and Technology Project of Guangdong Province of China 2018KJYZ005

Natural Science Foundation of Tibet Autonomous Region of China XZ2017ZR-ZY021

More Information

Corresponding author: Yang Lei, Email: yuanyang@smu.edu.cn

摘要

摘要: 快速、良好的促血管化目前仍然是创面修复生物材料研发面临的巨大挑战。目前研究表明创面血管化与生物材料的孔隙、成分、通道等密切相关。近年来，虽然新型医用功能材料的研发取得了突飞猛进的发展，其在重建皮肤屏障功能、调控创面微环境、抗菌消炎等方面取得可喜成果，但仍未解决创面快速血管化难题。该文介绍了创面血管化进程、生物材料促进创面血管化的策略、基于三维打印技术构建促进创面血管化的生物材料、纳米技术对创面血管化的影响，以期为未来快速血管化创面修复材料的研发提供新的启示。
- 生物相容性材料 /
- 新生血管化，生理性 /
- 打印，三维 /
- 创面修复 /
- 纳米材料
Abstract: Promoting rapid and good vascularization is still a great challenge for the research and development of biomaterials for wound repair. Current studies have shown that wound vascularization is closely related to the pores, components, and channels of biomaterials. Although the research and development of new medical functional materials have made rapid progress in recent years, and gratifying achievements have been made in the reconstruction of skin barrier function, regulation of wound microenvironment, and antibacterial and anti-inflammatory effects, etc., the problem of rapid wound vascularization has not been solved. This paper introduces the process of wound vascularization, the strategy of biomaterials promoting wound vascularization, the construction of biomaterials promoting wound vascularization based on three-dimensional printing technology, and the influence of nanotechnology on wound vascularization, in order to provide new enlightenment for research and development of wound repair materials with rapid vascularization in the future.
- Biocompatible materials /
- Neovascularization, physiologic /
- Printing, three-dimensional /
- Wound repair /
- Nanomaterials
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参考文献(42)

[1]	MiricescuD,BadoiuSC,ⅡStanescu-Spinu,et al.Growth factors, reactive oxygen species, and metformin-promoters of the wound healing process in burns?[J].Int J Mol Sci,2021,22(17):9512. DOI: 10.3390/ijms22179512.
[2]	WuM,LuZ,WuK,et al.Recent advances in the development of nitric oxide-releasing biomaterials and their application potentials in chronic wound healing[J].J Mater Chem B,2021,9(35):7063-7075.DOI: 10.1039/d1tb00847a.
[3]	ShahinH,ElmasryM,SteinvallI,et al.Vascularization is the next challenge for skin tissue engineering as a solution for burn management[J/OL].Burns Trauma,2020,8:tkaa022[2022-06-26].https://pubmed.ncbi.nlm.nih.gov/32766342/.DOI: 10.1093/burnst/tkaa022.
[4]	Masson-MeyersDS,TayebiL.Vascularization strategies in tissue engineering approaches for soft tissue repair[J].J Tissue Eng Regen Med,2021,15(9):747-762.DOI: 10.1002/term.3225.
[5]	WangY,FanY,LiuH.Macrophage polarization in response to biomaterials for vascularization[J].Ann Biomed Eng,2021,49(9):1992-2005.DOI: 10.1007/s10439-021-02832-w.
[6]	OmorphosNP,GaoC,TanSS,et al.Understanding angiogenesis and the role of angiogenic growth factors in the vascularisation of engineered tissues[J].Mol Biol Rep,2021,48(1):941-950.DOI: 10.1007/s11033-020-06108-9.
[7]	MarzianoC,GenetG,HirschiKK.Vascular endothelial cell specification in health and disease[J].Angiogenesis,2021,24(2):213-236.DOI: 10.1007/s10456-021-09785-7.
[8]	GonçalvesRC,BanfiA,OliveiraMB,et al.Strategies for re-vascularization and promotion of angiogenesis in trauma and disease[J].Biomaterials,2021,269:120628.DOI: 10.1016/j.biomaterials.2020.120628.
[9]	ChenL,LiZ,ZhengY,et al.3D-printed dermis-specific extracellular matrix mitigates scar contraction via inducing early angiogenesis and macrophage M2 polarization[J].Bioact Mater,2022,10:236-246.DOI: 10.1016/j.bioactmat.2021.09.008.
[10]	MinorAJ,CoulombeK.Engineering a collagen matrix for cell-instructive regenerative angiogenesis[J].J Biomed Mater Res B Appl Biomater,2020,108(6):2407-2416.DOI: 10.1002/jbm.b.34573.
[11]	NiuY,StadlerFJ,FangJ,et al.Hyaluronic acid-functionalized poly-lactic acid (PLA) microfibers regulate vascular endothelial cell proliferation and phenotypic shape expression[J].Colloids Surf B Biointerfaces,2021,206:111970.DOI: 10.1016/j.colsurfb.2021.111970.
[12]	GuoP,DuP,ZhaoP,et al.Regulating the mechanics of silk fibroin scaffolds promotes wound vascularization[J].Biochem Biophys Res Commun,2021,574:78-84.DOI: 10.1016/j.bbrc.2021.08.026.
[13]	CzerwinskiM,SpenceJR.Hacking the matrix[J].Cell Stem Cell,2017,20(1):9-10.DOI: 10.1016/j.stem.2016.12.010.
[14]	RahimnejadM,Nasrollahi BoroujeniN,JahangiriS,et al.Prevascularized micro-/nano-sized spheroid/bead aggregates for vascular tissue engineering[J].Nanomicro Lett,2021,13(1):182.DOI: 10.1007/s40820-021-00697-1.
[15]	YuR,ZhangH,GuoB.Conductive biomaterials as bioactive wound dressing for wound healing and skin tissue engineering[J].Nanomicro Lett,2021,14(1):1.DOI: 10.1007/s40820-021-00751-y.
[16]	谭荣伟,刘曦,陈滢滢,等.不同三维多孔结构对人工真皮血管化速率影响的实验研究[J].中华烧伤杂志,2021,37(10):959-969.DOI: 10.3760/cma.j.cn501120-20200715-00347.
[17]	MehdizadehH,SumoS,BayrakES,et al.Three-dimensional modeling of angiogenesis in porous biomaterial scaffolds[J].Biomaterials,2013,34(12):2875-2887.DOI: 10.1016/j.biomaterials.2012.12.047.
[18]	HernandezJL,WoodrowKA.Medical applications of porous biomaterials: features of porosity and tissue-specific implications for biocompatibility[J].Adv Healthc Mater,2022,11(9):e2102087.DOI: 10.1002/adhm.202102087.
[19]	GongT,ZhaoK,LiuX,et al.A dynamically tunable, bioinspired micropatterned surface regulates vascular endothelial and smooth muscle cells growth at vascularization[J].Small,2016,12(41):5769-5778.DOI: 10.1002/smll.201601503.
[20]	LiJ,ZhangT,PanM,et al.Nanofiber/hydrogel core-shell scaffolds with three-dimensional multilayer patterned structure for accelerating diabetic wound healing[J].J Nanobiotechnology,2022,20(1):28.DOI: 10.1186/s12951-021-01208-5.
[21]	LiJ,LiuX,TaoW,et al.Micropatterned composite membrane guides oriented cell growth and vascularization for accelerating wound healing[J].Regen Biomater,2023,10:rbac108.DOI: 10.1093/rb/rbac108.
[22]	KasetsirikuS,KetpunD,ChuahYJ,et al.Surface creasing-induced micropatterned gelma using heating-hydration fabrication for effective vascularization[J].Tissue Eng Regen Med,2021,18(5):759-773.DOI: 10.1007/s13770-021-00345-0.
[23]	GaoJ,YuX,WangX,et al.Biomaterial-related cell microenvironment in tissue engineering and regenerative medicine[J].Engineering,2022,13(6):31-45. DOI: 10.1016/j.eng.2021.11.025.
[24]	WangY,KankalaRK,OuC,et al.Advances in hydrogel-based vascularized tissues for tissue repair and drug screening[J].Bioact Mater,2022,9:198-220.DOI: 10.1016/j.bioactmat.2021.07.005.
[25]	DongL,YangY,LiuZ.3D printing of biomimetic vasculature for tissue regeneration[J]. Materials Horizons,2019,6(6):1197-1206. DOI: 10.1039/C9MH00174C.
[26]	FengC,ZhangW,DengC,et al.3D printing of lotus root-like biomimetic materials for cell delivery and tissue regeneration[J].Adv Sci (Weinh),2017,4(12):1700401.DOI: 10.1002/advs.201700401.
[27]	SuH,LiQ,LiD,et al.A versatile strategy to construct free-standing multi-furcated vessels and a complicated vascular network in heterogeneous porous scaffolds via combination of 3D printing and stimuli-responsive hydrogels[J].Mater Horiz,2022,9(9):2393-2407.DOI: 10.1039/d2mh00314g.
[28]	XiaP,LuoY.Vascularization in tissue engineering: the architecture cues of pores in scaffolds[J].J Biomed Mater Res B Appl Biomater,2022,110(5):1206-1214.DOI: 10.1002/jbm.b.34979.
[29]	JoshiA,ChoudhuryS,GugulothuSB,et al.Strategies to promote vascularization in 3D printed tissue scaffolds: trends and challenges[J].Biomacromolecules,2022,23(7):2730-2751.DOI: 10.1021/acs.biomac.2c00423.
[30]	YangQ,PengJ,XiaoH,et al.Polysaccharide hydrogels: functionalization, construction and served as scaffold for tissue engineering[J].Carbohydr Polym,2022,278:118952.DOI: 10.1016/j.carbpol.2021.118952.
[31]	JungK,CorriganN,WongE,et al.Bioactive synthetic polymers[J].Adv Mater,2022,34(2):e2105063.DOI: 10.1002/adma.202105063.
[32]	AliabouzarM,LeyA,MeursS,et al.Micropatterning of acoustic droplet vaporization in acoustically-responsive scaffolds using extrusion-based bioprinting[J].Bioprinting,2022,25:e00188.DOI: 10.1016/j.bprint.2021.e00188.
[33]	YanezM,RinconJ,DonesA,et al.In vivo assessment of printed microvasculature in a bilayer skin graft to treat full-thickness wounds[J].Tissue Eng Part A,2015,21(1/2):224-233.DOI: 10.1089/ten.TEA.2013.0561.
[34]	KhannaA,AyanB,UndiehAA,et al.Advances in three-dimensional bioprinted stem cell-based tissue engineering for cardiovascular regeneration[J].J Mol Cell Cardiol,2022,169:13-27.DOI: 10.1016/j.yjmcc.2022.04.017.
[35]	LiC,HanX,MaZ,et al.Engineered customizable microvessels for progressive vascularization in large regenerative implants[J].Adv Healthc Mater,2022,11(4):e2101836.DOI: 10.1002/adhm.202101836.
[36]	LuoY, ZhangT, LinX.3D printed hydrogel scaffolds with macro pores and interconnected microchannel networks for tissue engineering vascularization[J]. Chemical Engineering Journal,2022, 430:1385-8947. DOI: 10.1016/j.cej.2021.132926.
[37]	ArakawaC,GunnarssonC,HowardC,et al.Biophysical and biomolecular interactions of malaria-infected erythrocytes in engineered human capillaries[J].Sci Adv,2020,6(3):eaay7243.DOI: 10.1126/sciadv.aay7243.
[38]	ZarubovaJ,Hasani-SadrabadiMM,BacakovaL,et al.Nano-in-micro dual delivery platform for chronic wound healing applications[J].Micromachines (Basel),2020,11(2):158.DOI: 10.3390/mi11020158.
[39]	XieZ,ParasCB,WengH,et al.Dual growth factor releasing multi-functional nanofibers for wound healing[J].Acta Biomater,2013,9(12):9351-9359.DOI: 10.1016/j.actbio.2013.07.030.
[40]	MooreMJ,TanRP,YangN,et al.Bioengineering artificial blood vessels from natural materials[J].Trends Biotechnol,2022,40(6):693-707.DOI: 10.1016/j.tibtech.2021.11.003.
[41]	WangC,ChuC,ZhaoX,et al.The diameter factor of aligned membranes facilitates wound healing by promoting epithelialization in an immune way[J].Bioact Mater,2022,11:206-217.DOI: 10.1016/j.bioactmat.2021.09.022.
[42]	QianS,WangJ,LiuZ,et al.Secretory fluid-aggregated Janus electrospun short fiber scaffold for wound healing[J].Small,2022,18(36):e2200799.DOI: 10.1002/smll.202200799.