肠黏液屏障与烧伤后肠道损伤修复的研究进展

吴丹; 苏森; 魏燕; 彭曦

doi:10.3760/cma.j.cn501225-20220701-00280

肠黏液屏障与烧伤后肠道损伤修复的研究进展

doi: 10.3760/cma.j.cn501225-20220701-00280

吴丹¹,
苏森¹,
魏燕¹,
彭曦^2, ,

1.
陆军军医大学（第三军医大学）第一附属医院临床医学研究中心，重庆　　400038
2.
陆军军医大学（第三军医大学）临床医学研究中心，全军烧伤研究所，创伤、烧伤与复合伤国家重点实验室，重庆　　400038

基金项目:

国家自然科学基金面上项目 82172202

详细信息

通讯作者:
彭曦，Email：pxlrmm@163.com

计量
- 文章访问数: 188
- HTML全文浏览量: 183
- PDF下载量: 33
- 被引次数: 0
出版历程
- 收稿日期: 2022-07-01

Research progress of intestinal mucus barrier and the repair of intestinal damage after burn injury

Wu Dan¹,
Su Sen¹,
Wei Yan¹,
Peng Xi^{2
, ,}

1.
Clinical Medical Research Center, the First Affiliated Hospital of Army Medical University (the Third Military Medical University), Chongqing 400038, China
2.
Clinical Medical Research Center, Institute of Burn Research, State Key Laboratory of Trauma, Burns and Combined Injury, the First Affiliated Hospital of Army Medical University (the Third Military Medical University), Chongqing 400038, China

Funds:

General Program of National Natural Science Foundation of China 82172202

More Information

Corresponding author: Peng Xi, Email: pxlrmm@163.com

摘要

摘要: 肠黏液层是宿主先天防御的第1道防线，并为肠道菌群的生长提供能量，在调控肠道微生态和维护肠稳态等方面发挥重要作用。该文对肠黏液合成、分泌、加工与修饰进行综述，重点关注肠黏液屏障对烧伤后肠道损伤修复的影响及特殊营养素对烧伤后肠黏液屏障的调控作用。
- 烧伤 /
- 肠道营养 /
- 肠道菌群 /
- 肠道稳态 /
- 肠黏液合成 /
- 肠黏液分泌
Abstract: The intestinal mucus layer is the first line of innate host defense and provides energy for the growth of the intestinal flora. In addition, it plays an important role in regulating intestinal microecology and maintaining intestinal homeostasis. This paper reviews the synthesis, secretion, processing, and modification of intestinal mucus, and focuses on the effect of intestinal mucus barrier on intestinal injury repair and the regulation of intestinal mucus barrier by special nutrients after burn injury.
- Burns /
- Enteral nutrition /
- Intestinal flora /
- Intestinal homeostasis /
- Intestinal mucus synthesis /
- Intestinal mucus secretion
所有作者均声明不存在利益冲突

HTML全文

参考文献(43)

[1]	HeW,WangY,WangP,et al.Intestinal barrier dysfunction in severe burn injury[J/OL].Burns Trauma,2019,7:24[2022-07-22].https://pubmed.ncbi.nlm.nih.gov/31372365/.DOI: 10.1186/s41038-019-0162-3.
[2]	GodlK,JohanssonME,LidellME,et al.The N terminus of the MUC2 mucin forms trimers that are held together within a trypsin-resistant core fragment[J].J Biol Chem,2002,277(49):47248-47256.DOI: 10.1074/jbc.M208483200.
[3]	DavisCW,DickeyBF.Regulated airway goblet cell mucin secretion[J].Annu Rev Physiol,2008,70:487-512.DOI: 10.1146/annurev.physiol.70.113006.100638.
[4]	TsuruA,FujimotoN,TakahashiS,et al.Negative feedback by IRE1β optimizes mucin production in goblet cells[J].Proc Natl Acad Sci U S A,2013,110(8):2864-2869.DOI: 10.1073/pnas.1212484110.
[5]	DasI,PngCW,OanceaI,et al.Glucocorticoids alleviate intestinal ER stress by enhancing protein folding and degradation of misfolded proteins[J].J Exp Med,2013,210(6):1201-1216.DOI: 10.1084/jem.20121268.
[6]	ThomssonKA,Holmén-LarssonJM,AngströmJ,et al.Detailed O-glycomics of the Muc2 mucin from colon of wild-type, core 1- and core 3-transferase-deficient mice highlights differences compared with human MUC2[J].Glycobiology,2012,22(8):1128-1139.DOI: 10.1093/glycob/cws083.
[7]	YaoY,KimG,ShaferS,et al.Mucus sialylation determines intestinal host-commensal homeostasis[J].Cell,2022,185(7):1172-1188.e28.DOI: 10.1016/j.cell.2022.02.013.
[8]	WeiX,YangZ,ReyFE,et al.Fatty acid synthase modulates intestinal barrier function through palmitoylation of mucin 2[J].Cell Host Microbe,2012,11(2):140-152.DOI: 10.1016/j.chom.2011.12.006.
[9]	MartensEC,NeumannM,DesaiMS.Interactions of commensal and pathogenic microorganisms with the intestinal mucosal barrier[J].Nat Rev Microbiol,2018,16(8):457-470.DOI: 10.1038/s41579-018-0036-x.
[10]	WheelerKM,Cárcamo-OyarceG,TurnerBS,et al.Mucin glycans attenuate the virulence of Pseudomonas aeruginosa in infection[J].Nat Microbiol,2019,4(12):2146-2154.DOI: 10.1038/s41564-019-0581-8.
[11]	BirchenoughGM,NyströmEE,JohanssonME,et al.A sentinel goblet cell guards the colonic crypt by triggering Nlrp6-dependent Muc2 secretion[J].Science,2016,352(6293):1535-1542.DOI: 10.1126/science.aaf7419.
[12]	ZhangT,SasabeJ,HullahalliK,et al.Increased Listeria monocytogenes dissemination and altered population dynamics in Muc2-deficient mice[J].Infect Immun,2021,89(4):e00667-20.DOI: 10.1128/IAI.00667-20.
[13]	FaderlM,NotiM,CorazzaN,et al.Keeping bugs in check: the mucus layer as a critical component in maintaining intestinal homeostasis[J].IUBMB Life,2015,67(4):275-285.DOI: 10.1002/iub.1374.
[14]	ShanM,GentileM,YeiserJR,et al.Mucus enhances gut homeostasis and oral tolerance by delivering immunoregulatory signals[J].Science,2013,342(6157):447-453.DOI: 10.1126/science.1237910.
[15]	JohnsonJL,JonesMB,RyanSO,et al.The regulatory power of glycans and their binding partners in immunity[J].Trends Immunol,2013,34(6):290-298.DOI: 10.1016/j.it.2013.01.006.
[16]	YangWY,ShaoY,Lopez-PastranaJ,et al.Pathological conditions re-shape physiological Tregs into pathological Tregs[J/OL].Burns Trauma,2015,3(1):1[2022-07-22].https://pubmed.ncbi.nlm.nih.gov/26623425/.DOI: 10.1186/s41038-015-0001-0.
[17]	EngevikMA,YacyshynMB,EngevikKA,et al.Human Clostridium difficile infection: altered mucus production and composition[J].Am J Physiol Gastrointest Liver Physiol,2015,308(6):G510-524.DOI: 10.1152/ajpgi.00091.2014.
[18]	SongY,LiY,XiaoY,et al.Neutralization of interleukin-17A alleviates burn-induced intestinal barrier disruption via reducing pro-inflammatory cytokines in a mouse model[J/OL].Burns Trauma,2019,7:37[2022-07-22].https://pubmed.ncbi.nlm.nih.gov/31890716/.DOI: 10.1186/s41038-019-0177-9.
[19]	彭曦,汪仕良,王凤君,等.不同营养支持途径对烧伤大鼠肠粘液屏障的影响[J].中华烧伤杂志,2002,18(6):339-342.DOI: 10.3760/cma.j.issn.1009-2587.2002.06.007.
[20]	HeazlewoodCK,CookMC,EriR,et al.Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis[J].PLoS Med,2008,5(3):e54.DOI: 10.1371/journal.pmed.0050054.
[21]	MelhemH, Regan-KomitoD, NiessJH. Mucins dynamics in physiological and pathological conditions[J]. Int J Mol Sci, 2021,22(24):13642. DOI: 10.3390/ijms222413642.
[22]	ShiY,WangC,WuD,et al.Mechanistic study of PDIA1-catalyzed TFF3 dimerization during sepsis[J].Life Sci,2020,255:117841.DOI: 10.1016/j.lfs.2020.117841.
[23]	SchroederBO.Fight them or feed them: how the intestinal mucus layer manages the gut microbiota[J].Gastroenterol Rep (Oxf),2019,7(1):3-12.DOI: 10.1093/gastro/goy052.
[24]	MagnottiLJ,DeitchEA.Burns, bacterial translocation, gut barrier function, and failure[J].J Burn Care Rehabil,2005,26(5):383-391.DOI: 10.1097/01.bcr.0000176878.79267.e8.
[25]	FengY,HuangY,WangY,et al.Severe burn injury alters intestinal microbiota composition and impairs intestinal barrier in mice[J/OL].Burns Trauma,2019,7:20[2022-07-01].https://pubmed.ncbi.nlm.nih.gov/31312663/. DOI: 10.1186/s41038-019-0156-1.
[26]	GaneshBP,KlopfleischR,LohG,et al.Commensal Akkermansia muciniphila exacerbates gut inflammation in Salmonella Typhimurium-infected gnotobiotic mice[J].PLoS One,2013,8(9):e74963.DOI: 10.1371/journal.pone.0074963.
[27]	WangQ,HuangSQ,LiCQ,et al.Akkermansia muciniphila may determine chondroitin sulfate ameliorating or aggravating osteoarthritis[J].Front Microbiol,2017,8:1955.DOI: 10.3389/fmicb.2017.01955.
[28]	NiuM,ChenP.Crosstalk between gut microbiota and sepsis[J/OL].Burns Trauma,2021,9:tkab036[2022-07-22].https://pubmed.ncbi.nlm.nih.gov/34712743/.DOI: 10.1093/burnst/tkab036.
[29]	CrabtreeSJ,RobertsonJL,ChungKK,et al.Clostridium difficile infections in patients with severe burns[J].Burns,2011,37(1):42-48.DOI: 10.1016/j.burns.2010.06.008.
[30]	ShoaeiP, ShojaeiH, SiadatSD, et al. Gut microbiota in burned patients with Clostridioides difficile infection[J]. Burns, 2022,48(5):1120-1129. DOI: 10.1016/j.burns.2021.11.023.
[31]	EngevikMA,EngevikAC,EngevikKA,et al.Mucin-degrading microbes release monosaccharides that chemoattract Clostridioides difficile and facilitate colonization of the human intestinal mucus layer[J].ACS Infect Dis,2021,7(5):1126-1142.DOI: 10.1021/acsinfecdis.0c00634.
[32]	WangZE,WuD,ZhengLW,et al.Effects of glutamine on intestinal mucus barrier after burn injury[J].Am J Transl Res,2018,10(11):3833-3846.
[33]	JiangQ,ChenJ,LiuS,et al.L-glutamine attenuates apoptosis induced by endoplasmic reticulum stress by activating the IRE1α-XBP1 axis in IPEC-J2: a novel mechanism of l-glutamine in promoting intestinal health[J].Int J Mol Sci,2017,18(12):2617.DOI: 10.3390/ijms18122617.
[34]	LiuJ,MarchaseRB,ChathamJC.Glutamine-induced protection of isolated rat heart from ischemia/reperfusion injury is mediated via the hexosamine biosynthesis pathway and increased protein O-GlcNAc levels[J].J Mol Cell Cardiol,2007,42(1):177-185.DOI: 10.1016/j.yjmcc.2006.09.015.
[35]	WangY,LiangK,KongW.Intestinal trefoil factor 3 alleviates the intestinal barrier function through reducing the expression of TLR4 in rats with nonalcoholic steatohepatitis[J].Arch Med Res,2019,50(1):2-9.DOI: 10.1016/j.arcmed.2019.03.004.
[36]	PelaseyedT,BergströmJH,GustafssonJK,et al.The mucus and mucins of the goblet cells and enterocytes provide the first defense line of the gastrointestinal tract and interact with the immune system[J].Immunol Rev,2014,260(1):8-20.DOI: 10.1111/imr.12182.
[37]	HoffmannW.Trefoil factor family (TFF) peptides and their diverse molecular functions in mucus barrier protection and more: changing the paradigm[J].Int J Mol Sci,2020,21(12):4535.DOI: 10.3390/ijms21124535.
[38]	WangZE,PengJ,WuD,et al.Effects of intestinal trefoil factor on intestinal mucus barrier in burned mice[J].Am J Transl Res,2020,12(11):7187-7198.
[39]	NelsonJL,AlexanderJW,GianottiL,et al.Influence of dietary fiber on microbial growth in vitro and bacterial translocation after burn injury in mice[J].Nutrition,1994,10(1):32-36.
[40]	BaiD,SunT,ZhaoJ,et al.Oroxylin A maintains the colonic mucus barrier to reduce disease susceptibility by reconstituting a dietary fiber-deprived gut microbiota[J].Cancer Lett,2021,515:73-85.DOI: 10.1016/j.canlet.2021.05.018.
[41]	BirchenoughG,SchroederBO,BäckhedF,et al.Dietary destabilisation of the balance between the microbiota and the colonic mucus barrier[J].Gut Microbes,2019,10(2):246-250.DOI: 10.1080/19490976.2018.1513765.
[42]	MorrowLE,GogineniV,MaleskerMA.Probiotics in the intensive care unit[J].Nutr Clin Pract,2012,27(2):235-241.DOI: 10.1177/0884533612440290.
[43]	FlemingD, JiangY, OpokuK,et al. Prophylactic probiotics in burn patients: risk versus reward[J]. J Burn Care Res, 2019,40(6):953-960. DOI: 10.1093/jbcr/irz132.