加强难愈合创面间充质干细胞治疗的基础与转化研究

史春梦

doi:10.3760/cma.j.cn501225-20220913-00405

加强难愈合创面间充质干细胞治疗的基础与转化研究

doi: 10.3760/cma.j.cn501225-20220913-00405

史春梦

陆军军医大学火箭军医学教研室，创伤、烧伤与复合伤国家重点实验室，重庆　　400038

基金项目:

国家自然科学基金重点项目 82030056

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出版历程
- 收稿日期: 2022-09-13

To strengthen the basic and translational research of mesenchymal stem cell-based therapy for refractory wounds

Shi Chunmeng

Institute of Rocket Force Medicine, State Key Laboratory of Trauma, Burns and Combined Injury, Army Medical University, Chongqing 400038, China

Funds:

Key Program of National Natural Science Foundation of China 82030056

摘要

摘要: 近年来，细胞疗法在难愈合创面修复领域的应用显示出广阔前景，其中间充质干细胞是最受关注和研究最为广泛的细胞类型。尽管临床转化研究已取得快速发展，但细胞疗法效果并不稳定，多数临床试验尚未取得预想结果。深入研究表明，异质性是制约细胞疗法深入开展和亟待研究的重要问题。该文基于间充质干细胞的研究进展，探讨难愈合创面细胞治疗策略的现状和挑战。
- 间充质干细胞 /
- 细胞和组织疗法 /
- 转化医学研究 /
- 难愈合创面 /
- 创面修复 /
- 异质性
Abstract: In recent years, the application of cell-based therapy in the field of refractory wound repair has shown broad prospects, among which the mesenchymal stem cell is the most concerned and widely studied cell type. Despite the rapid development of clinical translational research, the therapeutic effect of cell-based therapy is not consistent, and most clinical trials have not achieved the desired results. Further studies have found that heterogeneity is an important issue that restricts the further development of cell-based therapy and urgently needs to be studied. Based on the research progress of mesenchymal stem cells, in the review, we discuss the current status and challenges of cell-based therapy strategies for refractory wounds.
- Mesenchymal stem cells /
- Cell- and tissue-based therapy /
- Translational medical research /
- Refractory wounds /
- Wound repair /
- Heterogeneity
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