细胞衰老在慢性创面愈合中的作用研究进展

摘要: 慢性创面因其长期难愈的特性、严重不良的预后，给患者及其家庭与社会带来巨大压力和困难。近来，越来越多的证据表明细胞衰老在慢性创面中存在并影响创面愈合。该文通过回顾慢性创面中细胞衰老的特征，讨论细胞衰老与慢性创面愈合之间的关系，并总结当前一系列抗衰老策略，引出将细胞衰老作为潜在靶点治疗慢性创面的可能性。
- 细胞衰老 /
- 伤口愈合 /
- 慢性创面 /
- 衰老相关分泌表型
Abstract: Chronic wounds bring huge pressure and difficulties to patients, their families, and society due to their long-term refractory characteristics and serious poor prognosis. Recently, more and more evidences have proven that cell senescence exists in chronic wounds and affects wound healing. This article reviews the characteristics of cell senescence in chronic wounds, discusses the relationship between cell senescence and chronic wound healing, and summarizes current series of anti-senescence strategies to bring out the possibility of treating chronic wounds with cell senescence as a potential target.
- Cell aging /
- Wound healing /
- Chronic wounds /
- Senescence-associated secretory phenotype
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