胰石蛋白在脓毒症早期诊断中应用的研究进展

何婷; 刘伟; 申传安

doi:10.3760/cma.j.cn501225-20221120-00498

胰石蛋白在脓毒症早期诊断中应用的研究进展

doi: 10.3760/cma.j.cn501225-20221120-00498

解放军总医院第四医学中心烧伤整形医学部，北京　　100048

基金项目:

国家自然科学基金面上项目 82072169, 82272279

军队后勤科研项目保健专项 22BJZ35

军队后勤科研重大项目 ALB18J001

详细信息

通讯作者:
申传安，Email：shenchuanan@126.com

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- 文章访问数: 84
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- PDF下载量: 18
- 被引次数: 0
出版历程
- 收稿日期: 2022-11-20
- 网络出版日期: 2023-10-26

Research advances on application of pancreatic stone protein in the early diagnosis of sepsis

Department of Burns and Plastic Surgery, the Fourth Medical Center of PLA General Hospital, Beijing 100048, China

Funds:

General Program of National Natural Science Foundation of China 82072169, 82272279

Military Logistics Scientific Research Project Health Special Project 22BJZ35

Major Program of Military Logistics Research Plan ALB18J001

More Information

Corresponding author: Shen Chuan'an, Email: shenchuanan@126.com

摘要

摘要: 脓毒症是一种严重危及生命的综合征，其主要特征是宿主对感染的异常反应，可迅速演变为脓毒症休克和多器官功能衰竭。脓毒症的治疗依赖于早期识别和诊断以及充分而及时的抗感染和多器官功能支持。近年来，胰石蛋白作为一种新的脓毒症生物标志物被广泛研究。现有证据表明，与目前临床上常用的炎症标志物相比，胰石蛋白对脓毒症的诊断具有更高的敏感度和特异度，并且能对脓毒症进行早期识别，可在一定程度上评估脓毒症患者病情的严重程度。该文就胰石蛋白的特征、生物学功能、诊断特点以及临床应用的研究进展作一综述。
- 脓毒症 /
- 胰石蛋白 /
- 感染 /
- 诊断
Abstract: Sepsis is a severe life-threatening syndrome characterized by an abnormal host response to infection that can rapidly evolve into septic shock and multiple organ failure. Treatment of sepsis depends on early identification and diagnosis as well as adequate and timely anti-infection and multi-organ functional support. In recent years, pancreatic stone protein has been widely studied as a new biomarker for sepsis. Existing evidence shows that compared with the commonly used inflammatory markers in clinical practice, pancreatic stone protein has higher sensitivity and specificity in the diagnosis of sepsis. It enables the early diagnosis of sepsis and assessment of the severity of septic patients to a certain extent. This article reviews the characteristics, biological functions, diagnostic features, and clinical application of pancreatic stone protein.
- Sepsis /
- Lithostathine /
- Infection /
- Diagnosis
所有作者均声明不存在利益冲突

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