靶向树突状细胞的脓毒症免疫调理新策略

姚咏明; 张卉; 吴瑶

doi:10.3760/cma.j.cn501225-20230321-00087

靶向树突状细胞的脓毒症免疫调理新策略

doi: 10.3760/cma.j.cn501225-20230321-00087

解放军总医院医学创新研究部转化医学研究中心、第四医学中心，北京　　100853

基金项目:

国家重点研发计划 2022YFA1104604

国家自然科学基金重点项目 82130062, 82241062

详细信息

通讯作者:
姚咏明，Email：c_ff@sina.com

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- 文章访问数: 149
- HTML全文浏览量: 41
- PDF下载量: 24
- 被引次数: 0
出版历程
- 收稿日期: 2023-03-21

Novel strategy of sepsis immunomodulation targeting dendritic cells

Translational Medicine Research Center, Medical Innovation Research Division and the Fourth Medical Center of PLA General Hospital, Beijing 100853, China

Funds:

National Key Research and Development Program of China 2022YFA1104604

Key Program of National Natural Science Foundation of China 82130062, 82241062

More Information

Corresponding author: Yao Yongming, Email: c_ff@sina.com

摘要

摘要: 树突状细胞是介导机体天然免疫和获得性免疫应答的主要抗原提呈细胞。脓毒症状态下，树突状细胞数目减少，抗原提呈能力减弱，分泌细胞因子异常，造成T淋巴细胞活化障碍。既往研究提示，树突状细胞数目和功能变化是导致免疫功能抑制的主要原因之一。笔者针对脓毒症时树突状细胞的变化特点，结合其目前的研究进展，简要分析并提出了靶向树突状细胞凋亡、分化和功能等方面的免疫调理新策略，以期为严重烧创伤并发脓毒症的有效防治提供新思路。
- 脓毒症 /
- 免疫，细胞 /
- 树突细胞 /
- 免疫反应 /
- 免疫调理 /
- 干预策略
Abstract: Dendritic cells (DCs) are the major antigen-presenting cells that play critical roles in regulating both innate and acquire immune responses. In the state of sepsis, the number of DCs is obviously decreased with inhibited antigen presenting ability as well as abnormal cytokine secretion, thereby resulting in an impairment of T lymphocyte activation. Previous studies have demonstrated that the depletion and dysfunction of DCs appear to be the main causes associated with the development of sepsis-induced immunosuppression. Based on the characteristic changes of DCs in sepsis and analysis of recent research progress, the authors propose a novel strategy of immunomodulation targeting the apoptosis, differentiation, and dysfunction of DCs, in order to provide new ideas for the prevention and treatment of severe burns and trauma complicated with sepsis.
- Sepsis /
- Immunity, cellular /
- Dendritic cells /
- Immune response /
- Immunomodulation /
- Interference strategy
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